Loperamide is actually a failed pain medication. When tested it didnt have analgesic properties, but it had the side effect of constipation, so they re marketed it. Through some experimentation, a buddy of mine noticed when taking loperamide (he didn't specify dosages) and adding half his normal dose of opiates, he got the same affects as his normal dose. Different people react to medications differently though, and I wouldn't advise mixing drugs.