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neurotoxicity of 6-apb

T

till101

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hi,
6-APB is variant of the research chemical 6-APDB developed in the 1990s by David E. Nichols while investigating non-neurotoxic MDMA analogues. Are there any paper about it´s neurotoxicity ?

peace
 
MDA's increased neurotoxicity in relation to MDMA is mediated via greater DA release. Subjective reports indicate that 6-APB's increased similarity to MDA in contrast to MDMA is due to more pronounced 5ht2a agonism.

ebola
 
I think its role in monoamine release has yet to be tested, although this is something I would also be interested in learning. From the limited information available on the subject, it has been described as probably a 5HT2C agonist, 5HT2B maybe, and probably 5HT2A, like ebola mentioned. No idea the values. And I'm not sure when someone's going to invest in neuroendocrine testing for something like this. Doesn't seem likely to happen anytime soon.
 
I am not aware of the technical science, but from experience, I assume that 6-apb is more neurotoxic than MDMA. I have little experience with MDA so I cannot compare it to that, but I've consistently had more challenging comedowns with 6-apb compared to MDMA. 6-apb is an impressive substance, producing very similar effects to MDMA, but overall I find MDMA to be a superior substance. One night of 6-apb has kept me somewhat down for a month, whereas with MDMA I usually feel fine after a couple days.
 
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Toast to the Spirits said:
I am not aware of the technical science, but from experience, I assume that 6-apb is more neurotoxic than MDMA. I have little experience with MDA so I cannot compare it to that, but I've consistently had more challenging comedowns with 6-apb compared to MDMA. 6-apb is an impressive substance, producing very similar effects to MDMA, but overall I find MDMA to be a superior substance. One night of 6-apb has kept me somewhat down for a month, whereas with MDMA I usually feel fine after a couple days.
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Has anyone else experienced an extended comedown from 6-APB? TTTS, have you tried 5-APB? What was your experience with that, if so?
 
DroneLore said:
Has anyone else experienced an extended comedown from 6-APB? TTTS, have you tried 5-APB? What was your experience with that, if so?
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I have not tried 5-apb, and I doubt I will go out of my way to get any kind of apb in the future. I must add though, that every time I tried 6-apb, I re-dosed at least once, totaling at least 300 mg. in a night. However, I usually go overboard with MDMA too, on a bad night upwards to around seven hundred mg., but I like to keep it under 500 mg.. I have two points: first that 6-apb may not be so bad if used responsibly (100 mg. topped with another 50 mg. an hour or two later, once in a blue moon), and second, I have a far easier time coping with an occasional overuse of MDMA than I do with an occasional overuse of 6-apb. This may have something to do with the fact that I cannot sleep after a night with 6-apb for at least 24 hours, despite having already been up for an additional 12 hours prior to the first dose. The day after 6-apb, I have a hard time with balance as I walk around, I'm very exhausted, and I find it much harder to shower, eat, or basically do anything good for me, unlike MDMA where the next morning I'm already working on my recovery, practically ready to hit the gym. Basically with 6-apb, I could literally lay in bed for two days straight after having come down, not doing shit. I have to really work up the drive to get started again with my life (basically impossible the next day).
 
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