• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Neuropathic pain disorders, and their treatment?

JohnBoy2000

JohnBoy2000

Bluelighter
Joined
May 11, 2016
Messages
2,596
Having experienced only the slightest touch of chronic'ish pain recently, it has certainly got me to thinking of and considering this area.

www.resetketamine.com

Ketamine for Trigeminal Neuralgia — Reset Ketamine - Ketamine Infusion Clinic in Palm Springs, California

Trigeminal neuralgia (also known as tic douloureux) is a chronic pain condition affecting the fifth cranial nerve (1). There are twelve cranial nerves that emerge from the brain and cranial nerve V carries sensation from the face to the brain.
www.resetketamine.com www.resetketamine.com

Ketamine was being hailed a potential wonder drug in depression, unsure how that's panned out.

I had saw it used for nerve pain disorders to apparent positive effect, but for the devastating condition outlined in that link, I just had to check if it had been researched and found effective.

They found that ketamine had significantly longer duration of pain relief at 2 weeks, 1 month, 2 months, and 3 months without serious side effects for up to three months. The ketamine infusion group also had a decrease in the use of carbamazepine by patients.
Click to expand...

Hopefully I'll never need to avail of chemicals for the purpose of alleviating a chronic pain disorder, but I'm interested to learn more about potential treatments.
 
themoodcenter.com

Can Ketamine Treat Trigeminal Neuralgia?

Trigeminal neuralgia is a distressing condition marked by intense facial pain. Explore benefits of ketamine for trigeminal neuralgia & improve your quality of life. Read more.
themoodcenter.com themoodcenter.com

Article released this year.

Ketamine’s mechanism of action in managing trigeminal neuralgia lies in its ability to block NMDA receptors and inhibit the transmission of pain signals. By doing so, ketamine disrupts the hyperexcitability of nerves associated with trigeminal neuralgia and provides relief from the debilitating pain experienced by patients. Additionally, ketamine has been found to have anti-inflammatory properties that can further contribute to its analgesic effects.
Click to expand...
 
I have ear neuralgia (geniculate neuralgia caused by partial auricular chain neuropathy, a form of small-fibre neuropathy). It is likely related to the problems that have affected my ears for several years, but the nerve pain problem is recent and happened after a second encounter with COVID-19 (the XBB strain) in late 2022.

I either have to go on Tegretol which isn't great, but at least it will allow me to sleep better, it doesn't do great things for your hearing from what I'm told but it can reduce the excitability of any nerves that have been affected by viruses. It's either that or slowly lose out on sleep and possibly go insane.
 
How about CBD?
Yeah, cannabis helps with a lot of stuff. Anxiety, depression, chronic pain. It's sad that it's not legal everywhere. In the UK, there are even medical cannabis clinics, like Alternaleaf. I would want something like that.
 
Last edited:
Flynnal said:
I have ear neuralgia (geniculate neuralgia caused by partial auricular chain neuropathy, a form of small-fibre neuropathy). It is likely related to the problems that have affected my ears for several years, but the nerve pain problem is recent and happened after a second encounter with COVID-19 (the XBB strain) in late 2022.

I either have to go on Tegretol which isn't great, but at least it will allow me to sleep better, it doesn't do great things for your hearing from what I'm told but it can reduce the excitability of any nerves that have been affected by viruses. It's either that or slowly lose out on sleep and possibly go insane.
Click to expand...

Sorry you are dealing with this. Amazing how viruses can have such long lasting effects.
 
SeekingOblivian said:
Sorry you are dealing with this. Amazing how viruses can have such long lasting effects.
Click to expand...

COVID attacks nerves in 2 different ways. One way is to damage blood vessels that supply oxygen to the nerves, and the other is to directly attack the nerve itself directly or indirectly through latent herpes reactivation.

It is possible for the vaccine to also cause latent viral reactivation (as is the case with any vaccine since the immune system is distracted). One way to avoid this is to take a course of Valtrex or Famvir for a week after the vaccine or whilst one tests positive with COVID. Risks of the vaccine are far outweighed by the risks of a COVID infection, so you are much better off getting the vaccine and avoiding the vast majority of the potential damage, at least in my case. I've been hit by COVID last year too around the same time. I came down literally on Christmas day. It's such an insult.
 
paranoid android said:
I have trigeminal neuralgia and ketamine will stop a attack outright. Sadly its kind of a bitch for me to get so im stuck with much inferior morphine and gabapentin
Click to expand...
Jebus.

Has your neuralgia improved any, and for how long have you suffered from it?

Do expect it to ever resolve, and how do you get through life, if I may ask?
 
JohnBoy2000 said:
Jebus.

Has your neuralgia improved any, and for how long have you suffered from it?

Do expect it to ever resolve, and how do you get through life, if I may ask?
Click to expand...

It has improved. Ive had it since about 2006 now i guess so nearly 20 years. I dont expect it will ever get completely better
 
You must log in or register to reply here.
Top