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neurontin, lyrica, benzo's and dependency

bob123

Bluelighter
Joined
Jul 7, 2006
Messages
398
Do drugs such as neurontin and lyrica cause the same physical dependency as benzos? I have heard conflicting information about this. Could it be that lyrica does but neurontin does not? Woulden't all drugs that work on GABA create physical dependency?
 
Does anyone know? This is kind of important as I am deciding on a medication for anxiety, so I would appreciate it of anyone could shed some light one this.:)
 
its not the same as benzos, but they can cause some kind of dependency. and yeah, this is more true for lyrica than neurontin, hence the schedule V rating (lyrica; neurontin has none)
 
Could it be that neurontin causes no dependency? And how do they cause depedency since they are not GABA agonists? Don't they simply mimic GABA's structure?
 
Theres a lot of people in this forum who could answer that but none of them seem to be around

you could maybe try searching, I seem to remember something, check the archive or maybe even check Other Drugs
 
I am almost sure that Neurontin/Gabapentin doesn't cause addiction or withdrawals symptoms, while Lyrica/Pregabalin does...
 
gabapentin doesn't cause addiction, because it doesn't directly modulate GABAergic synapses; I didn't think pregabalin did either, as it also doesn't directly modulate GABAergic synapses.
 
Isn't lyrica simply a more potent version of neurontin though? Why would lyrica cause dependency but not neurontin? Could it be becuase of the dopamine link?
 
Pregabalin and gabapetin -should- be the same...

But who says there is a dopamine link?
 
is there any recreatonal use for Lyrica? Since it is scheduled, I'm guessing that it has been a problem for some reason.

If it is used as a rec, what doses do people take?
 
"Pregabalin is not known to be active at receptor sites associated with drugs of abuse" (Pfizer's prescribing information). Some people however abuse Gabapentin which really perplexes me, because in my experience it does produce any pleasurable effects (unless you get a kick out of dizziness and sedation). Apparently, according to anecdotal reports it induces euphoria in some people. This seems to be the reason why Pregabalin has been scheduled.

"Preclinical studies indicated that pregabalin is transiently and sporadically self-administered at rates greater than vehicle but substantially lower than active comparators pentobarbital (CII) and methohexital (CIV). In clinical trials, pregabalin produces some pharmacological effects characteristic of diazepam and alprazolam and is likely to be abused for its positive psychic effects. The percentage of individuals that experienced acute euphoric effects was unusually high for pregabalin in clinical trials."

This is straight from the horse's mouth as it were: http://www.deadiversion.usdoj.gov/fed_regs/rules/2005/fr0728.htm
 
bharper said:
is there any recreatonal use for Lyrica? Since it is scheduled, I'm guessing that it has been a problem for some reason.

If it is used as a rec, what doses do people take?

I second that. What doses people take w/o combining with opiates/benzos/etc, which seems to be the most common use I hear of it.
 
bharper said:
is there any recreatonal use for Lyrica? Since it is scheduled, I'm guessing that it has been a problem for some reason.

If it is used as a rec, what doses do people take?

It is often compared to XTC or GHB...

From my experience, it's only slightly recreational... A bit like benzos, but without the relaxed and chilled out feeling...
It's also a bit like alcohol, without the physical effects, only the clouded mind...

I think 600mg Lyrica is a good starting dose for recreational effects (take less than that if you already take benzos, opiates, or any other CNS depressants)
 
"I am almost sure that Neurontin/Gabapentin doesn't cause addiction or withdrawals symptoms, while Lyrica/Pregabalin does..."


How is this as they are almost an identical drug?
 
neurontin+alcohol is a recreational combo, in that it makes one extra chatty and feel-good-y, but not in an amphetamine-like way. Heightened disinhibition is what I'm saying. If you take it regularly, or by itself, you're not likely to achieve any rec. effects.

I've read anectdotal accounts, and have experienced this myself, that there are withdrawals with Neurontin. Additionally, I would think there'd be some sort of seizure threshold issues upon discontinuation.

I wouldn't say WDs would be anywhere near Benzo WDs though
 
Water and alcohol are not really similar at all though. They're not chemically similar, and they're definately not pharmacologically similar.

The same can not be said for pregabalin and gabpetin.
 
Neurontin does not cause addiction but you can't just stop taking it. It is an anti-seizure medication and was marketed by pfizer pharmaceutical for many off-label uses. It is actually less effective than a placebo for anxiety and bipolar. If you suddenly stop taking it you can have a seizure. It is also a very nasty drug and intolerable by most people, causing unpleasant thoughts to say the least. Many have committed suicide. I took this drug for nearly 6 months and it wrecked my brain. I was too dumb to do anything. Neurontin is garbage do not take it. There has been a federal lawsuit against pfizer for its off-label marketing. People have died but doctors have gotten rich. Evil stuff, this chemical should never have seen the light of day.
 
Water and alcohol are similar in some formalistic way: H-OH , CH3-OH , C2H5OH ...

Water is just the most simple alcohol.And no,you can't get high on it :)
 
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