• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

neuronal apoptosis inhibitors to treat amphetamine neurotoxicity?

23536

23536

Bluelight Crew
Joined
Dec 16, 2010
Messages
7,725
Location
Stop resisting!
1) are any commercially available?
2) are they safe?
3) are any specific to dopaminergic neurons?

I've quit Adderall, but I'd still like to know in case I go back on Adderall and/or become a crackhead again and/or get a license to practice medicine


evidence that amphetamine induces apoptosis (full text articles):


apoptosis inhibitors/modulators in the pipeline as of 2009:

AEG-33773, ANAVEX-1-41, Anti-apoptotic gene therapy (IAP), APG-101, Bortezomib, DP-109, DP-b99, Dykellic acid, GAI-122, M-40401, MX-4565, Olesoxime (formerly TRO-19622), Omigapil, VAR-10300 (former M-30), Xaliprodene, XG-102​
 
inhibiting apoptosis is a really bad idea. might be less a problem in parkinson's and huntington's patients, but it's generally a good way to get cancer.
 
I'd concede that for cells that are able to undergo mitosis. But neurons?
Click to expand...

Brain tumors happen too, you know. And good luck finding a compound wizardly selective enough to exclusively limit the benefit (and risk) to the CNS alone. Apoptosis often happens there for a good reason - the brain simply hadn't taken extensive neurotoxic drug use into account whilst forging those intricate processes by which it culls dysfunctional cells no longer amenable to harmonious function with their neighbors. Granted, natural selection often makes mistakes, but as Hammilton was quick to point out, the benefits of pharmacologically inhibiting apoptosis would seem commensurate to the potential risk only in cases of rampant degeneration.

evidence that amphetamine induces apoptosis (full text articles):
http://www.fasebj.org/content/early/...81fje.full.pdf
http://jpet.aspetjournals.org/content/315/1/91.full.pdf
Click to expand...

Of these two papers, only the former directly suggests apoptosis as a mechanism by which amphetamine induces loss of ganglial DA density. Only the latter explicitly employs dosages relevant to human use. If you have practical concerns over potential neurotoxicity, why not just adhere to less specious modalities, like neuroprotective antioxidants or facilitators of mitochondrial metabolism? Acetylcarnitine and lipoic acid are certainly better (safer) bets than wholesale inhibitors of controlled cell death.
 
I'll come back to this in a few days. Apparently there are no apoptosis inhibitors in current medical use, so I doubt anyone can say how specific AI's are.

ps: how does nerve cancer work? do the neurons go back into the cell cycle?
 
This is kind of like trying to prevent fires by flooding the building... There isn't really a huge base of evidence to suggest that there are strongly negative things resulting from loss of neurons from amphetamine use, so I wouldn't worry about it a lot more than you worry about your cell phone causing cancer.
 
why on earth have people ever believed that cell phones can cause cancer? The radiation that causes cancer is in high energy frequencies, Gamma, X and UV Rays, all have enough energy to break covalent bonds in DNA and other molecules. The frequencies cell phones operate on aren't even close to that. I remember last fall this was in the news how some study found increased risk for only the very heaviest users- but even though the study says this is probably just a statistical anomaly, the news leads with "Could you Cell Phone Give You Cancer?" stupid people...
 
235360287471352662 said:
I've quit Adderall, but I'd still like to know in case I go back on Adderall and/or become a crackhead again and/or get a license to practice medicine
Click to expand...

I was about to say otherwise but it seems cocaine (HCl) is also associated with cerebral and vascular apoptosis, although I can find little suggesting the same for methylphenidate so maybe it is not a property of all NDRIs.

Methylphenidate has always seemed like the wisest psychostimulant path to travel down.
 
completely off topic but OP it must be a hassle to type out ur name every time u log in lol
 
hamhurricane said:
I was about to say otherwise but it seems cocaine (HCl) is also associated with cerebral and vascular apoptosis, although I can find little suggesting the same for methylphenidate so maybe it is not a property of all NDRIs.

Methylphenidate has always seemed like the wisest psychostimulant path to travel down.
Click to expand...

IIRC methylphenidate does promote apoptosis. Maybe it's just related to DA auto-oxidation.
 
Minocycline has been reported to inhibit apoptosis, and is neuroprotective in general through various mechanisms
 
Minocyline is neuroprotective? Interesting, I would have thought otherwise considering it's thought that its ability to penetrate the BBB is responsible for causing a host of side effects.
 
Amu said:
Minocycline has been reported to inhibit apoptosis, and is neuroprotective in general through various mechanisms
Click to expand...

Stuff rapes mitochondrial biogenesis, heads up.

However, for preventing apoptosis its a fairly solid option. But, my experience with it scared me of it forever. Deep dissociation and depression for about 20 months is the last thing anyone needs.

The depression for me lasted for about a year after discontinuing until I started taking CoQ10.
 
You must log in or register to reply here.
Top