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Neurochemicals most intimately involved with cognitive and executive function?

xbandit07x said:
No norepinephrine enhancement alone normally fails with people that have the energy to come on the internet anyway already. I'm sure some people out there can respond well to Wellbutrin I won't try it because I really do not want to switch to that format of Drug.
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That
That format meaning - antidepressants?

Just FYI - I'm crashed on my bed all day.
Barely enough energy to go to the bathroom.
I can pick my way through this but, I don't see how it's possible to have a whole lot LESS energy...
 
JohnBoy2000 said:
That
That format meaning - antidepressants?

Just FYI - I'm crashed on my bed all day.
Barely enough energy to go to the bathroom.
I can pick my way through this but, I don't see how it's possible to have a whole lot LESS energy...
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I would say if your energy is that low if you abused drugs or have not, underlying health issues would trump any and all medications.

Do you really feel tired going to the bathroom or is it just that hard to care.
 
And yeah anti depressants I just don't seem to have much faith in from the massive amounts of no anecdotal evidence of a positive experience, and for someone genetically inclined to have crushingly low Dopamine (Comt Val/val) I can say it's unlikeky I'd be assisted by things besides Dopamine release agents.

My Dopamine is so low, I can smoke copious amounts of marijuana on Dexedrine and never reach a state of paranoia, it's an infinite distance away.

25% of the population is Comt Val/val.

If your so fatigued you can't move out of a bed. Do not take drugs. It's a health issue with your hormones, thyroid, stomach, endocrine system, cellular energy issue.

We're much more unhealthy now than our ancestors, whom could take moderate doses of Dexedrine for years and not notice more than caffeine like withdrawal.

Are we too unhealthy physically and spiritually to get any benefits from the drugs that work?
 
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JohnBoy2000 said:
Are you suggesting that adderall could be beneficial, where methylphenidate was not??

I don't know respective mechanisms of action so....
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Yeah methylphenidate is beneficial for the scatter brained but it's not going to help you if you can't generate your own Dopamine or motivation.

Even using amphetamine to cover up a total body health or vitamin related problem is unsafe.
 
Nope - not a health issue.
Been down that road.

I respond to anti-depressants - nothing else.

Alright, I can go to the bathroom, but I mean, I could literally do NOTHING else this evening, apart from lie here.


Next question.

I'm based in europe.
I'd like to try adderall, amphetamines - but they're not licensed, only ritalin is - which I've tried to not a fantastic outcome.

Any idea how i could acquire said amphetamines?

I wasn't aware of their difference from ritalin in terms of implicated neurochemicals, so when ritalin didn't work, I assumed nothing from that class would work.
 
I also tried marijuana with tobacco.

Made me sick.
Certainly didn't benefit from it.

Is there any particular strain of marijuana that is more beneficial?
i.e. incites greater dopamine release?
 
Have you had a hair metals test?

Have you checked blood for candida allergens?

Have you checked for Pyroluria? (Genetic condition where you expel b6 and zinc)

Have you had cortisol tested?

Isn't there Dexedrine prescribed in the U.K., but not adderall?

As far as marijuana, some strains make perceived fatigue better and others make it worse. This usually isn't related to indica vs sativa.

But yea Medical cannabis is much better than most pharmaceuticals, not the Good ones though.
 
wiki has me believe that both ritalin and dexedrine act on NE and DA, but the latter acting also as a releasing agent, as well as a RI.

Would it really be worth my while sourcing dexedrine when ritalin showed very little effect?
 
Limpet_Chicken said:
And what is maladaptive daydreaming disorder?
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One might describe it as when one delves much too deeply into the practice of somewhat intentional daydreaming, living out intricate fantasy lives sometimes to the point where they can be very irritated when somebody else disrupts their fantasy by speaking with them etc.
 
JohnBoy2000 said:
wiki has me believe that both ritalin and dexedrine act on NE and DA, but the latter acting also as a releasing agent, as well as a RI.

Would it really be worth my while sourcing dexedrine when ritalin showed very little effect?
Click to expand...

Just FYI source discussion is not allowed on bluelight and is a good way to get an otherwise okay thread closed fast :\

But amphetamines and Ritalin are pretty different. Amphetamines lead to much higher peak concentrations of NE/DA by reversing the reuptake transporters and causing them to spill neurotransmitters out into the synapse, whereas reuptake inhibitors just plug up the reuptake transporters and don't let them vacuum anything in.
 
xbandit07x said:
Even using amphetamine to cover up a total body health or vitamin related problem is unsafe.
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This, although I think one should extend the definition of health problem. I just don't know if amphetamines are a long term solution to MDD, I certainly haven't heard of it used for that purpose clinically.

DXM would probably be much better to investigate. There is also memantine.

NMDA receptors provide a lot of excitatory input to inhibitory interneurons that inhibit dopaminergic neurons. By blocking the NMDA receptors, the downstream dopaminergic neurons activity increases. Opiates work in a similar way, opoid receptors located on presynaptic GABA interneurons are linked to inhibitory pathways, that is to say that when an opoid binds to a mu-opoid receptor (MOR) it inhibits the cell. The MOR is located pre-synaptically on the GABA interneuron while the post synaptic cell is dopaminergic. This means that when MOR activity increases, it inhibits the pre-synaptic inhibitory GABA cell's release of GABA, so neurotransmission downstream (post-synaptically) increases. Not saying that opoids are good long term solutions either but I have at least heard of their use in MDD in last resort scenarios. But I would try NMDA antagonists (and ketamine especially, its worth a flight) first. But DXM should be readily available.
 
the iontropic acetylcholline receptors are pro-dopaminergic...

Amp was created to be a decongestant

Weed offers no cognitive benefit to the great majority of those who use it

Good to get vitamin levels tested

People can't accurately directly link their feelings to their neurochemical activity, unless they're going through a drug withdrawal. Even then, we don't know very much.

JohnBoy: we don't help people get drugs/get high. The thread would be closed.
 
I think those impulse-propagation fosterers like PPAP and BPAP would be most interesting. They are such fascinating drugs. phenylpropylaminopentane etc and benzofuranylaminopentane (BPAP)
 
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