Nepicastat

[Captain.Heroin]

https://en.wikipedia.org/wiki/Nepicastat

I wonder if the people the DoD provided for the study were extreme cases hence why this drug didn't work? Seems like a decent thing to try out for PTSD. Thoughts? Why didn't they try another phase 2 trial with a new population?

 

[novaveritas]

https://en.wikipedia.org/wiki/Nepicastat

I wonder if the people the DoD provided for the study were extreme cases hence why this drug didn't work? Seems like a decent thing to try out for PTSD. Thoughts? Why didn't they try another phase 2 trial with a new population?

Maybe you are right that the subjects were extreme, but this drug failed a pretty low bar, the subjects were randomized into the active and placebo group, and any effect would be seen in analysis, instead there was no significant difference to placebo.
There really is no point in testing again, the drug is already approved and this trial was an effort to get it a new drug indication.
The drug has failed several P2 trials at least one carried out by the original company before 2012 one carried out by the merged company Biotie in 2012 it is a dead end.
There is one well tested solution to the PTSD problem faced by military, stop traumatizing your soldiers by fighting pointless neocolonial wars an ounce of prevention being worth a pound of cure an all, but there's no money in that.

 

[Captain.Heroin]

There is one well tested solution to the PTSD problem faced by military, stop traumatizing your soldiers by fighting pointless neocolonial wars an ounce of prevention being worth a pound of cure an all, but there's no money in that.

That's such a cop-out and you know it. Once you have it, PTSD is a condition that needs addressing. People get PTSD without going overseas and fighting wars.

Please keep the war-bashing to CE&P.