In the midst of a grief related period, I tried Aropax (Paroxetine) for a week. I stopped because I was tripping full time, and anxiety was worse than ever.
I was smoking 6-8 joints a day when taking the SSRI. I really didn't think at the time that this would have caused the unbearable drug induced sense of strange tripping, or a complete inability to sleep - 5 days straight - and the heightened feelings of anxiety; anxiety being something I rarely noticed from dope itself.
But after reading the above posts, I'm beginning to think smoking may have contributed considerably, and it does make good sense. Going against the Dr's advice at the time, I went off Aropax and tried valium for the grief, which I found effective.
I did an experiment a year or so later and took a 20mg aropax without smoking or taking any other drugs including coffee for that day. The feelings were recognisable as soon as it came on - frustrated anxiety.
I know a girl who used aropax for a buzz, taking 60-80mg everyday as a starting dose. This really fucked her up, and to make matters worse she was E'ing, speeding and drinking as well, upping the MDMA dose to compensate for down-regulation or 5HT depletion. She's off it all now, but not surprisingly still has lots of troubles.
Another guy I know has been on Aropax since 94. Once a big smoker, he said the Aropax had made him feel like giving up dope, which he did. His dose was 60mg/day when I last saw him over 2 years ago. He experienced twitching and other discomforts, but accepted them in preference to how he is without the drug, which is impossible to describe without shocking. He had also changed in appearance, displaying similar characteristics that long term MAOI's users seem to.
I have the Aropax pharmacology paper released by the company in 1992. It states Aropax should only be used when taken in doses not exceeding 40mg/day. There is no consideration of patients being on the drug long enough for a developed tolerance to require doses higher than 40mg. Does this mean it was considered a cure?
An interesting side note is that Paroxetine has much of the MDMA molecule in its structure. Were designers trying to emulate some of the properties of MDMA with this invention? I don’t know of any other antidepressant drugs modeled around the methylenedioxyphenyl group.
Paroxetine = (-)-trans-4R-(4'-fluorophenyl)-3S-[(3',4'-methylenedioxyphenoxy) methyl] piperidine HCl hemihydrate.
…and for the inevitable question; no, you cannot easily make MDMA from it.