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Stimulants Need information on NMDA antagonists tolerance prevention from stimulants

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Intheworldofnim

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Jan 21, 2013
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If anyone has any links or studies they can link me that suggest the possability of tolerance preventions from stimulants like amphetamine using an NMDA antagonist like memantine. thank you
 
I don't know if you've already done this, but you can search the web and pub med n such and try to track down some studies about your inquiry. I only mention it because sometimes people will just ask for resources and neglect to seek them out themselves.

I wouldn't mind being able to curb my stim tolerance some. Though I dont take them very often.
 
You can find links to the threads blight mentioned under my started threads. But, if you really want to try NMDA antagonists DXM, commonly found in cough medications, is the most accessible for most regions.
 
I was searching on Google Scholar for you and thought it was really funny that one of the first things that came up was a Bluelight thread! I really didn't think Google considered us to be that scholarly =D

Studies on NMDA antagonists preventing or slowing the increase of amphetamine tolerance are actually difficult to find. Perhaps that's why you're asking here? Many of the studies I was able to find are actually about how NMDA antagonists can prevent behavioural sensitization to amphetamines (in animals at least). But I don't think that preventing sensitization and preventing tolerance are mutually exclusive.

Just one example:
Although coadministration of N-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7–10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development. [source]
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There is one on magnesium increasing the effects of amphetamines, but it doesn't say anything about tolerance:
The results demonstrate that magnesium dose dependently increases the potency of [amphetamine] by producing greater behavioral effects at certain drug doses, by producing shifts to the left in dose-response functions, and by producing decreases in the ED50 as dose of magnesium increases. [source]
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One on preventing cocaine tolerance:

NMDA receptor inhibition prevents tolerance to cocaine. Male rats were treated with cocaine... half the animals were concomitantly treated with MK-801, a noncompetitive NMDA receptor antagonist. Both... tolerance and sensitization, were prevented by coadministration of MK-801, thus suggesting these two phenomena are different aspects of a common neuronal response in which NMDA transmission plays a crucial role. [source]
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Sorry I haven't been able to find anything better for you yet.

Epsilon Alpha - Do any of the threads on the topic in Advanced Drug Discussion have links to or quotes from relevant studies? They were too long for me to read through ;)
 
Hey, we didn't cover them in depth in the threads, but if I ever finish my med school interviews I'll try and work them into the Op for the current iteration :)
 
Swimmingdancer said:
I was searching on Google Scholar for you and thought it was really funny that one of the first things that came up was a Bluelight thread! I really didn't think Google considered us to be that scholarly =D

Studies on NMDA antagonists preventing or slowing the increase of amphetamine tolerance are actually difficult to find. Perhaps that's why you're asking here? Many of the studies I was able to find are actually about how NMDA antagonists can prevent behavioural sensitization to amphetamines (in animals at least). But I don't think that preventing sensitization and preventing tolerance are mutually exclusive.

Just one example:


There is one on magnesium increasing the effects of amphetamines, but it doesn't say anything about tolerance:


One on preventing cocaine tolerance:



Sorry I haven't been able to find anything better for you yet.

Epsilon Alpha - Do any of the threads on the topic in Advanced Drug Discussion have links to or quotes from relevant studies? They were too long for me to read through ;)
Click to expand...


yeah, the only things I could really find on google were other threads from here, the drug forums, addforums and social anxiety support which were the places I learned from originaly. What I needed was official information, reports on studies being conducted where they found that NMDA antagonists could prevent amph tolerance and sense many of the people who talked about claimed they found this information based of studies being done. So I wanted to know if anyone could link some information about it. Thats why I was forced to make a topic on here about it because that information isn't redeadily available on google.
 
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