need advice about combining mxe with other substances

[hollywood_cole]

hi all, frequent lurker, occasional poster, and i was looking to get some info on mxe in combination with other stuff (informed speculation is fine, i know a lot of this is pretty uncharted territory as far as scientific studies go).

anyway, the two substances i'm most curious about in combination with mxe are 4-fa and psilocybin. my understanding of things is that 4-fa causes significant dopamine release and that mxe is a DRI in addition to its NMDAr antagonism, but my pharmacology knowledge is limited to what i've picked up on the internet over the years, so i'm not sure how to think about the interaction there. at first, i'd have guessed that this would increase the odds of neurotoxicity, but then i remembered that SSRIs are reported as interfering with mdma and that there's speculation that SSRIs taken at the end of a roll could be neuroprotective. i'm more interested in 4-fa followed (hours) later by mxe, but the opposite order's interesting too.

i guess i'm not so worried about neurotoxicity in combo with psilocybin, because i never worry about neurotoxicity with psylocibin (not sure if that's wise, the more i think about it).

either way, would definitely be interested to hear any subjective experiences (first or second hand). more interested in the lower dosage ranges.

oh, and any speculation on mxe and kratom pitfalls would be nice. followed 15 mg mxe with some kratom tea the other night and enjoyed it a lot.

thanks in advance, and any corrections to my assumptions are very welcome, like i said, i'm just a dilletante compared to a lot of the regulars in ADD.

 

[sekio]

I think amphetamines etc outcompete MXE/ketamine pretty handily at DAT.

For what it's worth there is a MXE cominations thread in Psychedelic Drugs. Erowid's got lots of reports on MXE combos now too, including MXE+DPT... and of course there is no end of literature on ketamine.

IMO when used in moderation the only things you shouldn't be combining MXE with are alcohol or benzodiazepines... due to the risk of blackouts, memory loss, and other nastiness.
psychedelics, stimulants, and most opioids should be safe when used at responsible levels. (This last bit kind of goes against the MXE Combo guide in PD.. but if you're not doing humongous doses of opioids it shouldn't be a problem.)

 

[hollywood_cole]

cool, good to know on the DAT binding, and thanks for the link. should've used the search engine.

i've read a bunch of the trip reports on erowid, but it seems like a lot of them involve much larger doses than i'm interested in at this point, esp when it comes to the combinations.