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Nebulizing JWH-018 and similar compounds

Z

zbeeblebrox

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Joined
Aug 14, 2010
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Comments requested.

I have employed a variety of delivery methods of JWH, but I am looking for something that is more portable than vaporizing, and does not involve anything as noxious as smoking, thus nebulizing seems to make good sense.

My initial idea is to use a non-disposable portable ultrasonic nebulizer, such as can be found on ebay for $50 - $100 USD.

The next of course is the medium. I have considered both natural ethanol >99.5%, or isopropanol.

The nebulizers claim to be able to atomize between a 1mL and 7mL per minute, and most seem to request distilled water as the atomizing medium.

My thought was to dissolve JWH at a dose of 20mg/mL in ethanol, and prepare a ethanol and water solution at a ratio of 1:5 for nebulizing at a rate of 7mL per minute. This will produce a 28mg dose at 1 minute of nebulizing, with a 40 proof alcoholic mist, presuming:

1) The JWH ethanol solution does not precipitate out the JWH when added to water.
2) the JWH ethanol solution is nebulizable by ultrasonic stimulation.

Thus you have a nice solution that will last a long time, produce results very quickly, and is extremely clean. Comments? Suggestions on improvement?
 
Solubility in ethanol is not really great (even worse when water is added!!!), acetone again is preferred. But inhaling vapours of acetone is not a good idea either.

- Murphy
 
zbeeblebrox said:
solubility of ethanol is not under discussion, and acetone is not a viable alternative.
Click to expand...

zbeeblebrox said:
The next of course is the medium. I have considered both natural ethanol >99.5%, or isopropanol.
...
My thought was to dissolve JWH at a dose of 20mg/mL in ethanol, and prepare a ethanol and water solution at a ratio of 1:5 for nebulizing at a rate of 7mL per minute. This will produce a 28mg dose at 1 minute of nebulizing, with a 40 proof alcoholic mist, presuming:

1) The JWH ethanol solution does not precipitate out the JWH when added to water.
2) the JWH ethanol solution is nebulizable by ultrasonic stimulation.

Thus you have a nice solution that will last a long time, produce results very quickly, and is extremely clean. Comments? Suggestions on improvement?
Click to expand...
Are you fucking kiddin' me? You suggested several times to dissolve the drug in ethanol, but solubility in ethanol is not under discussion? Is this the illiterate forum or ADD?
 
If you want to discuss jwh solubility rates and what doesn't work or isn't viable for human consumption, there are tons of threads for that, this is not one of them. This thread, however, is about the nebulization of jwh or problems thereof.
 
And for nebulization you need to dissolve the compound! I don't give a damn about solubility rates, I was just trying to tell you that your idea simple doesn't work, at least not with the suggested solvent system. But somehow you don't want to understand...
 
zbeeblebrox said:
The next of course is the medium. I have considered both natural ethanol >99.5%, or isopropanol.
Click to expand...

It was already noted. If there is an advantage for one over the other for direct nebulization that is interesting information. If JWH precipitates out of ethanol/propanol solution when added to water, that is also interesting information. However, the dissolving part isn't really difficult issue, as either ethanol or n-propanol will work.

I suppose this is similar to the e-cigarette issues. Except that e-cigarettes cannot contain enough liquid to sufficiently dose unless maybe you use DMSO and do 100 puffs, which might give you a bloody throat and lung cancer rather quickly. With the nebulizer, it can store and atomize multiple mL, so my concern isn't resevoir size or generic dissolution, but the stability and nebulization of a [(JWH/ethanol)water] mixture.
 
Nope, I'm rather frustrated.

I'll try it again...


zbeeblebrox said:
...This will produce a 28mg dose at 1 minute of nebulizing, with a 40 proof alcoholic mist, presuming:

1) The JWH ethanol solution does not precipitate out the JWH when added to water.
2) the JWH ethanol solution is nebulizable by ultrasonic stimulation.
Click to expand...

With regard to 1): It will precipitate when water is added. If a sufficient amount already dissolves in anhydrous ethanol is already questionable, too.

With regard to 2): JWH-018 was described as being "somewhat" soluble in isopropanol (by somebody who knows with definite certainty); dunno what this means in numbers, but at least it means that solubility is anything but great.

If you don't want to consider other solvents, simply stick with iPrOH and try it out. As a sidenote, IIRC, inhaled alcohol is anything but benign to your respiratory organs.


- Murphy
 
would nebulization doses be equal to oral doses or smoked doses?
because IIRC smoked jwh-018 smoked is less than 5 mg
 
At 20 mg/mL and a 5 mg dose it would only take 0.25 mL of ethanol.

I don't understand why nebulizers aren't being explored more. Nobody even tried this. Propylene glycol should work for this too, for whatever JWHs remain legal, and shouldn't require more volume than an e-cig would. But of course, e-cig's already work well for JWHs. What makes the nebulizer attractive is the possibility of inhaling something which can't be vaporized.
 
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