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Phenethylamines NE-2CB

psilocybonaut

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Joined
Dec 25, 2006
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Long Beach/Orange County, CA
Does anyone have any experience with NE-2CB (N-Ethyl-2C-B)? I'm going to have a fair amount soon and was wondering if theres been any discussion of it on here. Search bar isnt yielding much.

Was told "is the dosage range of 2cb without the mindblow, visual around 20-25, much much more erotic in 15-20mg level than 2cb and even competitive with mdma on this point. with this one, you can go higher in dosage safely"
 
Nice, looking forward to your reports on this.

This recent paper has some pharmacological info on that compound. I was wondering how N-ethyl might influence other 2Cs, especially 2C-D.
 
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No, but I am sure people are eager to hear any report you may have. It was encountered in Finland multiple times by authorities and was basically never heard of again. To me that doesn't suggest it's anything mindblowingly good though.

I was under the impression that n-alkylation of psychedelic phenethylamines/amphetamines drastically lowers potency and psychedelic effects while increasing negative physical effects. We get that general conclusion from many papers and even pihkal.
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From pihkal regarding BEATRICE:
"QUALITATIVE COMMENTS: (with 20 mg) There was a gentle and demandingrise from the one to the three hour point that put me into anextremely open, erotic, and responsive place. I had to find afamiliar spot to orient myself, and the kitchen served that need. Asthe experience went on, it showed more and more of a stimulantresponse, with tremor, restlessness, and a bit of trouble sleeping.But there was no anorexia! An OK experience.

(with 30 mg) There is a real physical aspect to this, and I am notcompletely happy with it. There is diarrhea, and I am restless, andcontinuously aware of the fact that my body has had an impact fromsomething. The last few hours were spent in talking, and I foundmyself still awake some 24 hours after the start of the experiment.The mental was not up there to a +++, and yet the physical disruptionwas all that I might care to weather, and exceeds any mental reward.When I did sleep, my dreams were OK, but not rich. Why go higher?

EXTENSIONS AND COMMENTARY: This is another example of the N-methyl homologues of the psychedelics. None of them seem to produce stuff ofelegance. It is clear that the adding of an N-methyl group onto DOMcertainly cuts down the activity by a factor of ten-fold, and even then results in something that is not completely good. Three milligrams of DOM is a winner, but even ten times this, thirty milligrams of N-methyl-DOM, is somewhat fuzzy. In the rabbithyperthermia studies, this compound was some 25 times less active than DOM, so even animal tests say this is way down there in value."

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Regarding N-Me-DOB

"methyl-DOB's dose as greater than 8 mg orally and its duration as "probably rather long". Its onset was about 1.3 hours. Analogously to the case of other N-methylated phenethylamines, the potency of methyl-DOB is dramatically reduced compared to DOB, which has a listed dose of 1 to 3 mg orally.


At tested doses of 8 to 10 mg orally, the effects of methyl-DOB have been reported to include lightheadedness, spaciness, physical effects or body load, tight and rubby teeth, tenseness, exaggerated reflexes, pupil dilation, and next-day hangover. No clear psychoactive or hallucinogenic effects were described. The drug may also potentiate other psychedelic drugs even on the next day however, with a "severe response" to a low 5 mg dose of psilocybin 24 hours later occurring in one instance."

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From Structure–activity relationships of serotonin 5-HT2A agonists by David E. Nichols

"Effect of N-Alkylation - In contrast to the tryptamines, the phenethylamines generally cannot tolerate simple N-substitution, even with small groups such as methyl or ethyl (Table 2). Quite remarkably, however, whereas simple and short
alkyl groups lead to inactive compounds, the addition of an N-benzyl affords compounds with remarkable affinity and potency"

 
What I find confusing about about the paper allylbenzene posted was this comment

"though not directly comparable structurally, among the four 2C-like phenethylamines, all showed a very limited inhibition at SERT in the micromolar range, with only N-ethyl 2C-B exhibiting some inhibition at NET. This group of compounds showed the highest potency at the 5-HT2A receptor, TMA-6 displayed potency comparable to LSD, whereas N-ethyl 2C-B was more potent than LSD."

I'm assuming they are refering to "potency" in terms of binding affinity? Certainly not dosage... As 4DQSAR frequently says affinity ≠ efficacy
 
It's a tentative anecdotal report but since there's few reports about this compound, :
I have now heard two reviews of people who claim it's def active. One of those two people I've been in contact with for a couple years and feel like I can trust him. They both say it's def active and has an amazing body high. (source)

The 5-HT2A activity of N-ethyl-MDA interesting.

David E. Nichols: "Effect of N-Alkylation - In contrast to the tryptamines, the phenethylamines generally cannot tolerate simple N-substitution, even with small groups such as methyl or ethyl (Table 2)."
It looks like he only tested 1A, 2A and 2C.
What about HT4, 5, 6, 7...
 
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