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[NBOMe Subthread] Methods of Administration (ft "NBome + gastro resistant capsules?")

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shanepatsmith

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[NBOMe Subthread] Methods of Administration (ft "NBome + gastro resistant capsules?")

Would NBOMES (eg. 25i-nbome) work orally if places within "Gastro resistant" capsules? (the capsules used for any drug that must bypass the gastric system for example omeoprazole). I enjoy using the nbomes, but I can no longer be bothered take it via the buccal route. anyone have any info on this particular topic (gastro resistant capsules + NBOMES)

Sorry if this was already discussed in another thread, i couldn't find anything on it.

Thanks
 
Apparently not. I can't remember where I read that through so I can't cite a source.

(I think it's more appropriate to move to the general NBMOMe discussion and comparison thread)
 
You mean enteric capsules?

It is thought that NBOMes are broken down in the liver, not the stomach so enteric capsules would not be effective as food absorbed in the small intestine still goes to the liver (actually barely anything is absorbed through the stomach itself).

Would be a fascinating experiment to try though.
 
@Transform: I was about to suggest that same notion yes.

But first-hand experience is always welcome as confirmation.

@Shane: Why can you no longer be bothered to take them bucally?
(Also, I hope you are okay with other threads on the topic of ROA's soon being merged with yours - putting a different post in place as the OP)

@General:
I'm turning this into a "methods of administration" subthread. Please tell us which different routes of administration (oral, buccal, sublingual, intranasal, smoking / vaporisation, plugging, injection) you have tried and how they differed for you?

Personally I have only tried insufflation (using a solid carrier) and I got vasoconstriction related side effects (mostly cold extremities and mild cramping) that with 25D were hard to get used to. I was turned off by that and have since believed that possibly the route of administration had something to do with it. Rapid build up of peak plasma seems essential to get decent effect from a dose, apparently because tolerance is immediately formed. But it might also be that the more rapid absorption is, the stronger side-effects get as well. I am not sure if sublingual administration might delay absorption enough to limit side-effects without limiting the wanted effects. It's worth a try. At least it would be if I still had plans to take any in the foreseeable future.
 
Enteric capsules are used to prevent drugs from being exposed to stomach acid. I think the NBOMes are pretty stable against acid - the problem is a combination of 1st pass metabolism in the liver & poor oral BA. So enteric capsules wouldn't do much.
 
I think plugging 25i would be extremely efficient, at least compared to buccal/sublingual.



I really have no interest in this compound though, so I don't want to try it out lol. Vaporizing does seem like it would hold some promise though, I'd be interested in how others have fared with that
 
I think I remember reading that plugging doesn't really need a lower dose compared to buccal / intranasal but I might be wrong here...

Because I doubt that it would make the compound reach the drug faster than when used intranasally. Buccal is apparently a bit inferior to the two though yea. No idea by what margin. It would be cool if people could attach a % value to that.
 
Liquid insufflation worked quite well and reliably so for me, with somewhat higher potency than people report via other routes. I had a 1 mg/ml solution of 25C-NBOMe with a 20 drops/ml dropper, usually taking about five to seven drops (250-350 µg) to the nose at a time. The solution degraded slowly over time and had lost about half its potency about a year after preparation. If I could do it again, I'd make the solution 2 mg/ml so I didn't have to put so much water in my nose.
 
I had an 25c-NBOMe microdot recently. It dissolved between my upper lip and gum. It can also be crushed and insufflated though. It was pretty strong for 500μg
 
Last edited:
atara said:
Liquid insufflation worked quite well and reliably so for me, with somewhat higher potency than people report via other routes. I had a 1 mg/ml solution of 25C-NBOMe with a 20 drops/ml dropper, usually taking about five to seven drops (250-350 µg) to the nose at a time. The solution degraded slowly over time and had lost about half its potency about a year after preparation. If I could do it again, I'd make the solution 2 mg/ml so I didn't have to put so much water in my nose.
Click to expand...

I made my solution at 5mg/ml but based on how easy it dissolved with a little shaking and some added warmth from a hot water bath, I imagine even stronger concentrations are very easily achievable. I don't like the dropper idea, they're close but theyre not all that consistent.. They're definitely easier to carry around than a vial and an insulin pin though - but I don't do anything like this away from home so its not a concern of mine, dosing accurately is though.

I did this based on testing what my nose could easily hold. Maybe my nasal cavities are small, but once I hit .2ml water starts to drop one way or the other, so I figured Id want 1mg per .2ml and went from there.
 
atara said:
Liquid insufflation worked quite well and reliably so for me, with somewhat higher potency than people report via other routes. I had a 1 mg/ml solution of 25C-NBOMe with a 20 drops/ml dropper, usually taking about five to seven drops (250-350 µg) to the nose at a time. The solution degraded slowly over time and had lost about half its potency about a year after preparation. If I could do it again, I'd make the solution 2 mg/ml so I didn't have to put so much water in my nose.
Click to expand...

I never knew how long the NBOME is stable in solution for. It is good that you posted your loss in potency, no need to dilute more than a few doses at a time . Has anyone out there carried out tests to confirm shelf life of solutions with NBOME at various dilutions?
 
Couldn't notice any degradation yesterday, but there's a bit of discoloration with my solution (distilled water, 2.5mg/ml) after a year. That's 25c, btw, my 25i (2mg/ml) still looks fine
 
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