When it comes to opioids they are divided into natural (codeine & morphine), semi synthetic (oxycodone, hydrocodone, hydromorphone, heroin, etc), fully synthetic (fentanyl, Demerol, tramadol, methadone, etc).
With the fully synthetics IME, they release more dopamine than morphine or codeine which release mostly endorphins and histamines.
Fully synthetics like Demerol and especially fentanyl are almost devoid of histamine release as well as respiratory depression lessening with the semi synthetics, while the clearest manifested in the fully synthetics like fentanyl where respiratory depression, nod, cough suppression, and constipation factor are lessened to a significant degree, especially in comparison to the natural opiates.
Anybody here I think will agree that codeine & morphine give the highest amount of: respiratory depression, nod, cough suppression and constipation. Most people will say that morphine is the easiest in terms of withdrawls, I haven't been addicted to morphine but rather to a combo of codeine & poppy pods, which was okay in withdrawl.
A good example is heroin (semi) vs methadone (full), both powerful opioids and most people will say that even IV heroin gives less withdrawls than oral methadone. Heroin withdrawls (smoking) were on par with oxycodone (oral, instant release) but shorter (then again never used the equivalent of 1g heroin in oxy). Fentanyl withdrawls, after smoking 10mg a day of duragesic gel for 1-2 months daily or 3 months with on and off. Smoking was the most amazing rush I've ever had and I've always been afraid of needles so once I did a hit it, the rush took me to far away places but I went to sleep after smoking the rest of my stash and in the morning had to go to school with nothing (didn't plan ahead). I woke up in a state of near paralysis, like having the flu so bad you can't stand up because your bones are taped to the bed with the most painful sweats going. Couldn't do nothing and mentally complete fog and depleted.
If anyone else would like to join in with your experiences, please tell us the duration of the habit and the method of administration (MOA).
With the fully synthetics IME, they release more dopamine than morphine or codeine which release mostly endorphins and histamines.
Fully synthetics like Demerol and especially fentanyl are almost devoid of histamine release as well as respiratory depression lessening with the semi synthetics, while the clearest manifested in the fully synthetics like fentanyl where respiratory depression, nod, cough suppression, and constipation factor are lessened to a significant degree, especially in comparison to the natural opiates.
Anybody here I think will agree that codeine & morphine give the highest amount of: respiratory depression, nod, cough suppression and constipation. Most people will say that morphine is the easiest in terms of withdrawls, I haven't been addicted to morphine but rather to a combo of codeine & poppy pods, which was okay in withdrawl.
A good example is heroin (semi) vs methadone (full), both powerful opioids and most people will say that even IV heroin gives less withdrawls than oral methadone. Heroin withdrawls (smoking) were on par with oxycodone (oral, instant release) but shorter (then again never used the equivalent of 1g heroin in oxy). Fentanyl withdrawls, after smoking 10mg a day of duragesic gel for 1-2 months daily or 3 months with on and off. Smoking was the most amazing rush I've ever had and I've always been afraid of needles so once I did a hit it, the rush took me to far away places but I went to sleep after smoking the rest of my stash and in the morning had to go to school with nothing (didn't plan ahead). I woke up in a state of near paralysis, like having the flu so bad you can't stand up because your bones are taped to the bed with the most painful sweats going. Couldn't do nothing and mentally complete fog and depleted.
If anyone else would like to join in with your experiences, please tell us the duration of the habit and the method of administration (MOA).
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