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Natural nootropics

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Bucklecroft Rudy

Bucklecroft Rudy

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I placed this in ADD because I thought it could perhaps incite some neuroscientific discussion. Ive recently found that certain herbs and natural supps have various cognitive enhancing effects.
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Ginkgo Biloba:
Cocoa:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518374/figure/fig1/
Magnesium (Threonate form or Ororate)
Periwinkle extract (Vinpocetin),
N Acetyl-Cysteine:www.turkjbiochem.com/2008/058-063.pdf
http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01580.x/full
http://www.livestrong.com/article/502485-n-acetylcysteine-brain-inflammation/
Cinnamon:
Coconut oil:http://www.naturepacific.com/conten...oconut-oil-brain-food-prevent-Alzheimers.html
http://www.naturalnews.com/030971_coconut_brain_function.html

Almond oil :
Cod Liver oil:
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all have been found to exert a clarifying mental influence either by increasing cerebral oxygenation; providing readily available neuronal energy or even oreventing inflammation. Does anyone know of anything else that could exhibit nootropic effects? As addicts these sorts of things could well enable us to preserve our presence of mind well into old age.
 
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There are many many many.

Tulsi: I couldn't find any finished studies specifically related to cognition; stay tuned (http://www.ask4healthcare.com/healthcaresolutions/ClinicalDetail.aspx?id=CTRI/2010/091/006113). Yet there's a cornucopia of other basically proven benefits, and it has traditionally been used as a cognitive enhancer/coffee substitute (which is interesting because its also relaxing and alleviates the dammage that caffeine does to the adrenal glands), and it has shown effectiveness in treating dementia.

Fish Oil: http://www.sciencedaily.com/releases/2011/08/110817120220.htm
Caffeine: http://www.ncbi.nlm.nih.gov/pubmed/20182035, however this is only one opinion, and I contend that its ability to improve concentration in basically everyone, sheer energy given, and numerous anecdotal reports of the people around me point to otherwise.

Piracetam
Hydergine
http://www.naturdoctor.com/Chapters/Research/Cognitive_Enhancement.html

If I were you I'd pick to the most natural items available, though Piracetam has been widely used for a very long time as well as demonstrates nuero-protection.
 
I think that Caffeine can reduce cerebral oxygenation. The Daily Mail ran an investigation where the brains of habitual coffee drinkers were compared to alcoholics cannabis smokers etc and various holes were found. I would imagine stress would be a huge factor there however since ime coffee drinkers are gneerally your high powered business types who run high octane.

Cerebrolysin,Noopept and semax are the ultimate nootropics. Apparently they have been shown to actually repair brain tissue and regenerate damaged regions. The changes are permanent whereas most nootropics are only going to give you short term gains. The efficacy of anything natural we propose has to be measured against the three
 
Sources bro.

Keep in mind, MayoClinic/Livestrong states that one would have to consume four cups per day to incur negative effects (which doesn't surprise me): http://www.livestrong.com/article/497500-physical-damage-to-the-brain-from-caffeine/

"People who consume 200 mg to 300 mg of caffeine per day, which is roughly equivalent to two to four cups of coffee, typically experience no adverse side effects"

They also state it reduces brain inflammation.

http://www.livestrong.com/article/507912-caffeine-brain-damage/

"The study reported that people who regularly consume moderate amounts of caffeine had an inverse correlation to cognitive decline, meaning they were less likely to experience such declines as opposed to those who were not regular caffeine consumers."

I'd also like to state that it gives a good buzz and is ridiculously easy to come off of (at least for me).

Thousands of years of does well at measuring efficacy. Despite how much we known about the brain today compared to a decade ago, its still a mystery. I'm still ready for psycho-pharmacological discussion though.
 
Panax ginseng?
Bucklecroft Rudy said:
I think that Caffeine can reduce cerebral oxygenation. The Daily Mail ran an investigation where the brains of habitual coffee drinkers were compared to alcoholics cannabis smokers etc and various holes were found. I would imagine stress would be a huge factor there however since ime coffee drinkers are gneerally your high powered business types who run high octane.

Cerebrolysin,Noopept and semax are the ultimate nootropics. Apparently they have been shown to actually repair brain tissue and regenerate damaged regions. The changes are permanent whereas most nootropics are only going to give you short term gains. The efficacy of anything natural we propose has to be measured against the three
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Are you lumping piracetam in with the short term gains?
 
An interesting article:

http://www.sciencedirect.com/science/article/pii/S037887410700356X

In traditional herbal medicine, numerous plants have been used to treat age related cognitive disorders. In this review we compiled available literature from four Swiss university libraries, scientific journals and online database query's on plants and remedies used in traditional medicinal systems for such diseases. Over 150 plant species in various preparations and mixtures were found. European herbals from the 16th and 17th century alongside traditional Chinese and Indian medicinal works were the most prolific sources. The information is organised into geographic regions and when available the findings are discussed in the light of more recent scientific findings concerning their secondary metabolites and in vitro and in vivo activities relevant to dementia and Alzheimer's disease.
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The articles refer to many scholarly primary sources. Call it second hand knowledge if you will. I will try and post up the bibliographies at the very least in future. The DM source was just an interesting aside more than anything. A google scholar search didnt turn much up... i'll try pubmed because the caffeine thing is interesting since it was posed as a nootropic.
Piractam does have dimminishing returns and has to be redosed. Once the routine stops the gains dissapear so I would classify it as a short term solution.
 
Branch chain amino acids actually appear to rival the big three I nominatred above. http://www.impactaging.com/papers/v3/n5/full/100322.html

Above is a link to a relevant study, but there is a big one referring to rats who were subjected to tbi. The control group reecovered far slower than the treated group.

I considred purchasing supplements, but there have been some murmurings of neurotoxicity in the literature.www.springerlink.com/content/h00776342k813150/ here the link is excitotoxicity.

BCAA are actually supposed to regulate glutamatre and GABA. http://jn.nutrition.org/content/135/6/1557S.short

There was also a suggestion that a spike in BCAA leads to a dip in ARaA which in turn leads to reduced synthesis of monoamines
http://www.ncbi.nlm.nih.gov/pubmed/15930466

Milk and Rye are the two easiest sources of the three: Leucine Isoleucine and Valine. You can buy rye in bulk where a gram contains something like 200mg of Valine. The equivalent amount in a supplement would set you back by quite alot. Milk contains all three in adequate measures per cup too. I would recommend a bowl of cereal with rye maybe every other day. That alone would improve cognitive performance and stimulate neurogenesis with lasting results.
http://www.livestrong.com/article/244710-foods-containing-branched-chain-amino-acid/

The official party line seems to run that BCAA are nature's elixir, but buried in the scientific literautre is all this speculation about neurotoxicity. Given the fact that we all consume several grams of BCAA daily I would assume that dangerous levels are only ever approached in the 10's of grams. There isnt any dose discussion however.

336gServing Size: 1 Teaspoon (5.6g)Servings Per Container: 60
L-Leucine: 2.5gL-Isoleucine: 1.25gL-Valine: 1.25g
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The literature suggests that those amounts may be too much (Study of Italian footballers found susceptibility to brain injury caused by some sort of sensitising)
At the right Dietary** levels howerver, this was found to happen

1 Cup of milk
Leucine :0.4
Isoleucine:0.2
Valine :0.3

Source

100g Rye
Leucine :1
Isoleucine:0.6
Valine :0.8

Source
 
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I seriously fucking doubt dietary amino acids are neurotoxic, or most people would keel over from eating a large, high-protein meal.
 
Eleutherococcus senticosus

"Xu Y.J., Han C.J., Xu S.J., Yu X., Jiang G.Z., Nan C.H. "Effects of Acanthopanax senticosus on learning and memory in a mouse model of Alzheimer's disease and protection against free radical injury to brain tissue" Neural Regeneration Research 2008 3:2 (192-195)" cant find it online though

"The effects of Eleutherococcussenticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes
Ben T. Gaffneya, , , Helmut M. Hügelb, Peter A. Richb" http://dx.doi.org/10.1016/S0024-3205(01)01394-7

"Effect of Eleutheroccocus senticosus Extract on Human Physical Working Capacity
Asano Katsumi (1) ; Takahashi Tetsuzo ; Miyashita Misao ; Matsuzaka Akira ; Muramatsu Shigeji ; Kuboyama Morio ; Kugo Haruhiko ; Imai Jiro"
http://cat.inist.fr/?aModele=afficheN&cpsidt=19934271

Also most are about endurance or body fitness but I think there are also some nootropic hints maybe someone else can find more :)
 
sekio said:
I seriously fucking doubt dietary amino acids are neurotoxic, or most people would keel over from eating a large, high-protein meal.
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Something tells me that I piss you off.Just a slight hunch lol oh well

Its high amounts caused by supplementation Plus the neurotoxicity is of the subtle variety and happens at the molecular level only, that is it will cause slight shift in cognition mood memory etc

Moreover the point of that study was to prove exactly what you're proposing. Italian footballers practically were keeling over from their high protein diet.
 
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LOL the Daily Fail said what?? didn't they mention that all those including blue coloring in toothpaste can increase your risk of cancer more than even a ham salad on a Friday morning? 41% vs 34%

WHY does it have to be NATRUAL? and what is your aim/goal? Or do you just want a list of nat. noops? or per haps you want summit to help concentration/memory but mild/safe?
 
I only mentioned the daily mail out of interest. It doesnt have any reiability or credibility of course. I didnt see any links to the studies themselves either.
The aim is to find out how to maximise neurogenesis. None of the chemical nootropics other than the big three can create sustained results which persist beyond dosing regimen period. Things like blueberries and BCAA's can literally incite neural repair.
 
"WHY does it have to be NATRUAL? and what is your aim/goal? Or do you just want a list of nat. noops? or per haps you want summit to help concentration/memory but mild/safe"

Read the thread/extrapolate.

Bucklecroft Rudy said:
Something tells me that I piss you off.Just a slight hunch lol oh well
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We act hardcore over here in ADD. Its how we keep the data valid.
 
The aim is to find out how to maximise neurogenesis. None of the chemical nootropics other than the big three can create sustained results which persist beyond dosing regimen period. Things like blueberries and BCAA's can literally incite neural repair.
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And blueberries and branched-chain amino acids don't contain/aren't chemicals, of course...

Thread is over, go to basic drug discussion or imminst if you want to discuss fluff like this. This is far too vacuous a topic to turn a thread into "post everything about nootriopics here".

Feel free to come back with some actual studies and article excerpts, not just a list of links to Daily Mail and one-liner article abstracts. We have enough threads on repairing neurotoxicity already
 
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