Naloxone in Suboxen to stop OD?

[Coreyjoe]

Question....Since there is Naloxone in Suboxen, is it possible to utilize the Naloxone in the Suboxen in the situation when someone is ODing? Possible shooting them with the suboxen? Just a thought......Naloxone is "Narcan" right?

 

[nickeldick]

if someone is OD'ing you should attempt to get medical help, i dont think the amount of naloxone in a sub would be near enough to bring someone out of a serious flop

 

[Coreyjoe]

Getting medical attention as in the paramedics coming and shoot someone up with naloxone and then probably the police showing up. Id rather try to fix it myself if its possible.

 

[The Monkey Mantra]

Does your city have a Narcan training program? Find out if there's a local needle exchange and ask them. They'll prescribe you Narcan and teach you how to use it. You need to call the ambulance *anyway*, because the Narcan doesn't last very long.

 

[Hammilton]

I would think the buprenorphine would be much more effective than the naloxone present. At least it will win it's battle for receptor occupancy, which naloxone is going to lose.

You'd have to administer it SL, which may not be easy if you're overdosing.

It might work, especially in an overdose situation involving a long acting drug- one that gives you time to realize you've gone way over the edge.

If someone else has OD'd, get them help.

 

[Coreyjoe]

What does SL mean?

 

[Hammilton]

sublingual, obviously: as it is intended.

 

[Coreyjoe]

but if someone is overdosing I dont think taking it that way for the naloxone would be effective. I still havent received a straight answer for my question.

 

[Hammilton]

Are you being intentionally dense? The naloxone won't do a fucking thing. The buprenorphine will. What alternative routes are you going to give it through? IV? Sure, why not? I'm sure they'll appreciate the stroke.

IM? Not as fast, but at least they could get a neato abscess!

Either have injectable naloxone or call a fucking ambulance ASAP.

The only way this would be reasonable was in the case of an overdose on a long acting slow onset drug like Methadone, where you'd have plenty of time to see that you've gone way over and could administer it yourself.

There, now the exact same information has been presented twice. Junkies come up with the stupidest ideas.

 

[ez4u2c]

PULP FICTION hahah

 

[FrostyMcFailure]

Getting medical attention as in the paramedics coming and shoot someone up with naloxone and then probably the police showing up. Id rather try to fix it myself if its possible.

Amen, this will be obvious to the people who respond with experience so perhaps your not asking the right ? .

Anyone aware of a safe method to extract/separate the narloxene out of the XX amount of suboxone with a result pure & safe enough for IV administration. This is in theory of course if one were trrappped on a desert island with a loved one who had ODed seconds before being dropped out of the plane! (now thats one hell of a set up!)

 

[bagochina]

Dont even try to use Sub in an OD situation, I dont know about lately but the needle x-changes in Chicago were giving out ampules of Naloxone after you completed a brief classroom study thing. Shooting up sub is pretty pointless in some strange theory [not mine, well I guess it is my theory, ha] it might work but it wont be the Nalxone upseating the op8 molecules it will be the buprenorphine [speaking of non dependant op8 users]. Personally I believe the FDA put the Naloxone in Suboxone to smokesceen users into thinking that injecting sub. will precipitate w/d's specifically the Naloxone. 2mg [Naloxone] in a 8mg tablet was never enough to bring upon w/d's in me or anyone I have known. Buprenorphine is a massively barbed receptor when it seats it self, there is little to no chance of getting that ripped out of the receptor [Mu site?] hence the next to rare chance of an OD on Suboxone when taken with out benzos. When combining it with other meds or drugs the danger does increase but I have never seen an OD on Suboxone, have you? Other that the many reported cases in France but that was Subutex. I am starting to ramble.

Seedless

 

[MurphyClox]

I still havent received a straight answer for my question.

...which is not true, because THAT was in fact the answer:

...You need to call the ambulance *anyway*, because the Narcan doesn't last very long.

In other words: Even if the naloxone would win the "opioid-battle" (affinity-wise), it is the ligand with the shortest duration. That means that you're dosing yourself with an antagonist, whose effect will wear off quite fast. What will be left?! The buprenorphine... and then you die...

- Murphy

 

[Hammilton]

No, the buprenorphine will act as an antagonist in the presence of the full agonist, and will effectively block whatever agonist he OD'd on.

Considering the difficulty in OD'ing on buprenorphine, that doesn't seem like it'll be a real issue.