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  • N&PD Moderators: Skorpio

N-propylamphetamine

I'd love some information on MDPR. It seems entirely dose dependant and sensitive to even a 50mg increase, a dramatic response for a simple raise in dose. I'm surprised, usually if you're at 200mg anything, and only feeling a
"(with 200 mg) There are the slightest hints of physical response, mabe a smidgin of lightheadedness at the one hour point. Perhaps a slight teeth clench. Certainly there is no central mental effect." AKA--
PLACEBO

yeah, I'll take 350 mg if I were to even bother. Seems kind of weak in action in a comparitive MG vs MG of the other MDxx analogues.

Dunno. I'll look into it.
 
Coolio said:
Well, MDA is more euphoric and neurotoxic than MDMA. MDMA is more euphoric and neurotoxic than MDEA. I can't imagine MDPA being a particularly worthwhile recreational drug... I'm picturing it being about as fun as BDB.
Click to expand...

MDA more euphoric? Can you explain further why you think this is true?
 
So meth is supposed to be more potent than regular amphetamine right? About how many mg's of d-meth would equal like 50mg d-amphetamine?

In my limited experience with meth (really pure though like 99+%) it seemed weaker than Adderall or dexedrine per mg.. eating 50mg of pure d-meth seemed nowhere as potent as eating 50mg adderall or dexedrine.. i've eaten 100mg meth and it really didn't seem ultra potent - although more euphoric and more of a razor sharp focus i guess.

Maybe just that its got so much less side effects that it "feels" less potent.. It just seems like if i was prescribed only like 25mg desoxyn instead of like 50mg dexedrine it wouldn't "be enough"..
 
A Note on Amphetamine Dosages from the Merck Manual.

from The Merck Manual (on amphetamine abuse)
17th ed.
p. 1593:

"Hallucinations and delusions may occur; however, even massive doses are rarely fatal. Long-term users have reportedly injected as much as 15,000 mg [about a half ounce] of amphetamine in 24 hours without observable acute illness."

^--No wonder they're crazy. ;)

The most pure meth I've seen people inject at one time IV is 500 mg, and they tended to argue with each other a lot for a long time afterwards, as in days.

But, on the other end of the dosage spectrum, prescription dosages for Desoxyn / methamphetamine (10 mg pills) and Dexedrine or Adderall (30 mg amphetamine pills, maximum strength) are ridiculously low for a full grown adult. One hundred to 250 mg is ideal for me.

Based on what f&b posted (namely, that n-propylamp is 1/3rd as strong as meth by weight), it sounds to me like 350 to 750 mg n-propylamphetamine by mouth, vaporization, or snorting would lead to a raucous good time.

What is the legal status of n-propylphenylisopropylamine hcl
(N-(n)-propylamphetamine) in the US? Is it specifically scheduled? I think not.

N-(n)-Pr-Ph-IP-NH2.hcl would make for a great, new, cheap, delectable tasting research chemical if that data is correct. But, if it's anything like Shulgin's MDPR, mescaline scale dosages may be required.

Update: Interestingly, the major metabolites of N-(n)-propylamphetamine in humans excreted in the urine 24 hours after ingestion are 4-hydroxy-N-propylamphetamine and
4-hydroxy-3-methoxy-N-propylamphetamine. Rather strange.
 
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<pyridinyl_30> said:
Update: Interestingly, the major metabolites of N-(n)-propylamphetamine in humans excreted in the urine 24 hours after ingestion are 4-hydroxy-N-propylamphetamine and
4-hydroxy-3-methoxy-N-propylamphetamine. Rather strange.
Click to expand...

Strange indeed! 3-methoxy, eh?
 
Given what you guys know about each molecule's polarity and size (if you do), is there any reason to think that someone that gets strong central effects from propylhexedrine is also more likely to get strong central effects from proplyamphetamine? I've read mix reviews on each and figured some of the same factors might be at play.
 
I think you're confused because of the work "propyl" in both. Propylhexedrine is the cyclohexane analogue of methamphetamine (that is, replacing the aromatic benzene ring in methamphetamine with the fully saturated cyclohexane).

Propylamphetamine is amphetamine with an N-propyl group.

Propylhexedrine is 1-cyclohexyl-N-methylpropan-2-amine

Methamphetamine is N-methyl-1-phenylpropan-2-amine


There's no way to predict if you'd enjoy propylamphetamine because you enjoy propylhexedrine. It'd be reasonable to say you'd enjoy methamphetamine because you enjoy propylhexedrine, as these two are closely related- but if you enjoy stimulants, you'll probably enjoy meth.

You'd probably enjoy N-propylamphetamine too; there's a reason it's schedule 1.
 
^Ah, thanks for clearing that up. I had recently read over a discussion where the lesser ability of N-propylamphetamine to cross the blood brain barrier vs. ethyl and regular amphetamine was mentioned (hell, might of been this thread!). I was hoping the propyl in propylhexadrine meant it was pretty large--and, given that I did get strong central effects from it, that I had a BBB that was permeable to the similarly-sized/outfitted molecule I thought n-propylamphetamine was.

I haven't been able to turn up much on N-propylamphetamine experiences, but it doesn't sound good. Then again, propylhexedrine also has a pretty mixed reputation ...

Here's two quotes I dug up:

"If I have no other available resort, I'll go for propyl-amph (about 1/2-2/3 equivalency as dex) but prefer to use fluro-amph (4-FMP) at mid/low levels (40-75mg) with propyl."

"Someone I know just recently got ahold of some propylamphetamine and was utterly devastated by the effects. Initially more of a disassociative/sedative, in fact. The stimulant effects were impossible to slam on through and barely discernable until hours later. Like a k-hole distored to six hours, in a way."

A person on another board was claiming responses vary a lot, but that it mostly effected SERT and hardly did anything for NE and DA, and that it was a far more powerful vasoconstrictor than regular amphetamine.

Any experienced users care to add something?
 
I did not encounter any of these profound vasoconstrictive effects with propylamphetamine. In fact, I noted virtually no discernible peripheral effects at doses up to 120 mg (administered as two 60mg doses q4hr). Central effects are very mild--I would argue that the potency of propylamphetamine is around 1/3 that of regular amphetamine. The gentle boost provided by the compound was much more akin to a weaker DAT/NET uptake inhibitor such as modafinil, as opposed to a proper substrate like amphetamine itself. However, in my experience, it lacked the anxiolytic, yet pro-cognitive effects (the ability to slice through any 'mental fogginess') that makes dextroamphetamine such a perfect therapeutic psychostimulant.

A friend of mine, who does not have ADD and tends to experience a hypomanic reaction to moderate doses of dextroamphetamine, considered it to have "just the right amount of functional stimulant activity" for his purposes. He compared it to modafinil as well, mentioning that it felt kind of like methylphenidate, but lacked the "dirty feeling" peripheral tweakiness and the 'rush' / comedown of the rapid-acting methylphenidate. Methylphenidate often makes me feel tired (strange, I realize), but can still cause a general feeling of 'unease' in the periphery, so I can see where he is coming from on this point. Propylamphetamine thankfully lacks this property.

As for the possibility of dissociative-like effects: I certainly did not encounter any in my limited trial of the compound, nor has anyone I have spoken to. Either the anecdote reported above was a highly idiosyncratic response, or the individual did not actually ingest pure N-propyl-amphetamine. In my experience, the compound was physically translucent, gentle and rather ephemeral...but lacking the special beneficial qualities of dextroamphetamine that make it such a great therapeutic. For those in search of a recreational, rather than functional/therapeutic stimulant, I wouldn't expect propylamphetamine to have much appeal--it is not a balls-to-the-wall, 'tweak-a-thon' compound.
 
But, on the other end of the dosage spectrum, prescription dosages for Desoxyn / methamphetamine (10 mg pills) and Dexedrine or Adderall (30 mg amphetamine pills, maximum strength) are ridiculously low for a full grown adult.
Click to expand...

This full grown adult finds such doses dandy, if more for cognitive enhancement than recreation.

ebola
 
Are there any potential health effects to this one that aren't present with amph and methamph?
 
<pyridinyl_30> said:
Update: Interestingly, the major metabolites of N-(n)-propylamphetamine in humans excreted in the urine 24 hours after ingestion are 4-hydroxy-N-propylamphetamine and
4-hydroxy-3-methoxy-N-propylamphetamine. Rather strange.
Click to expand...

Why is this strange?
 
One question, where the fuck does one find such an 'exotic' amphetamine-type compound? Not unless you were synthesizing your own batches of the shit? To the OP, N-Propylamphetamine sucks dick.
 
a 3-methoxy group added during metabolism is rather odd. I don't think that's known to occur with any other amphetamine.
 
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