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N-methyl & N-ethyl 3,4-dimethoxyamphetamines

why? 3,4-DMA doesn't seem particularly dangerous- considering a patient was given 700mg and apparently survived just fine.

A more potent version of this sounds quite good.
 
Really, 700mg? 4-Methoxy-amphetamine is deadly and I can't imagine 3-methoxyamphetamine being all that good for one. TMA, however, is extraordinary, from what I have read, so perhaps 3,4-DMA might be psychedelic.

Ham: what makes you think N-methyl-3,4-DMA would be more potent? The N-methyl analogues of the psychedelic amphetamines (TMA, DOC, DOI) are supposedly completely inactive.
 
Well, excepting MDMA, of course.

Looking at what shulgin has to say on the matter (#126 DMMA), perhaps it will be inactive or be really unpredictable.

I was thinking it might follow the MDA -> MDMA formula, but probably with the extra carbon (and not being locked into place) it has no chance of that sort of sparkle.
 
I would love to try some of each.

TMA and mescaline--with their 3,4-di-MeO groups--are definitely active, and
3-MeO-MA is said to be like ecstasy. The extra methyl group on the N-methyl group makes that nitrogen more basic. And the closely related 4-OH-3-MeO-MA is a metabolite of both meth and MDMA.

To top it all off, N-methyl and N-ethyl 3,4-di-MeO-amphetamines could be made from clove bud oil (eugenol). For that matter, why haven't more people tried plain 3,4-di-MeO-amp (3,4-DMA)?

We need more spice amphetamines to try!
 
I'm pretty sure that 3,4-DMMA will be inactive, considering that all the other DMMA's were (or most likely were).
 
I have a hunch that that rule doesn't apply to the strictly 3,4-disubstituted amphetamines. For example, I believe N-methyl-3,4-dichloroamphetamine would be active as well. Or, N-methyl-4-bromo-3-methoxyamphetamine.

Plus, from PiHKAL, we know that 4-ethoxy-3-methoxyphenethanamine is active, so I'm sure its amphetamine homologue would be as well (both from vanillin). Any drug made from something that tastes as good as vanillin has got to be good!

I'd like to try 4-ethyl-3-methoxyamphetamine as well. For every 2,4,5-pea there is a corresponding 3,4-pea, and I wager that the 3,4's are better in most instances than the 2,4,5's. A whole book could be written about it even.
 
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3-methoxy-4-ethyl-amphetamine sounds a tad less sketchy that any of the 3,4-dimethoxy compounds. Considering the nastiness of 4-MeO-amphetamine, I'd keep any electron-rich groups away from the 4-position (but the 2,4,5s seem to work).
 
I'm thinking that the other groups make it a less potent MAOI.

Does anyone know if the x,x,4-TMA's are even weak MAOIs
 
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