N-methyl-1-(pyridin-2-yl)propan-2-amine

[ingo_1978]

I was wondering whether this would be active? or with a sulphur in the ring instead of the nitrogen?

 

[sekio]

Probably not, if it is, I would expect it to be even nastier than the thiphene analog (5 membered ring with sulphur) that's floating around.

 

[Waterwalker]

Nah, too polar to cross the BBB

 

[ingo_1978]

Is there nothing you could replace one of the carbons with on the benzene ring which would still cross the brain barrier?

 

[mad_scientist]

the pyridin-3-yl isomer is reportedly active though fairly weak, but expect lots of peripheral side effects as the BBB penetration will be poor as stated above

 

[atara]

I don't think oxazoles are that polar. At least, they're not basic. They're also metabolically safer than thiophene, I believe.

 

[ingo_1978]

Would it make much difference where the nitrogen\sulphur was... I have tried the 2-thiophene analouge and thought it was nice, somehow I feel it is more of a serotonin releaser than dopamine, doesn't have the same instant hit a it's phen brother... could moving the substituted molecule to a different position change this?

 

[Hammilton]

Reminds me too much of histamine.

 

[Hyperthesis]

I was wondering whether this would be active? or with a sulphur in the ring instead of the nitrogen?

This is chemically not possible.

 

[nuke]

answered