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N-(2,4,6-trimethylphenyl)phthalimide all over Japan

EvS

EvS

Bluelighter
Joined
Nov 26, 2007
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31
Here's a curiosity from the archives..
mg0207_fig2.jpg

The Forensic Science Laboratory of the Osaka Prefectural Police Headquarters (Japan) recently received 11 mottled, brownish-pink tablets with an “S” logo, suspected Ecstasy (see Photo 2). The exhibits were seized by the Osaka Prefectural Police from two users in Osaka city. The tablets were 6.2 millimeters in diameter, 4.5 millimeters thick, and averaged 130 milligrams each. Analysis by color testing, TLC, and GC/MS, however, indicated no controlled substances. Additional analyses by GC/CI MS, LC/MS/MS and NMR analyses indicated N-(2,4,6-trimethylphenyl)phthalimide (approximately 15 milligrams/tablet) along with lesser amounts of one of its probable precursors, 2,4,6-trimethylaniline. Very little information is available concerning this compound; based on its structure, it may have a sedative effect (and the users so claimed). An internet search on N-phenyl-phthalimides indicates derivatives with herbicidal, anticancer, and other, rather obscure pharmaceutical activities - but no derivatives with any known abuse potential. To our knowledge, this is the first report of N-(2,4,6-trimethylphenyl)phthalimide in any clandestine sample. Since this submission, more than 300 tablets of the same kind have reportedly been seized in Osaka, Tokyo, Iwate, Kagawa, and several other Prefectures in Japan.
http://www.usdoj.gov/dea/programs/forensicsci/microgram/mg0207/mg0207.html

You guys know anything about this? I don't even know where to begin.
 
for what ..the abstract summary is simply briefly explains points about the structures but i think not all that illuminating in any practical sense
 
wait a second- I thought it was a paper about anti-convulsant properties of this class. I didn't actually read that page, I took the shroomers word on it.

that's what you get.
 
That is the only menton I have ever seen of N-(2,4,6-trimethylphenyl)phthalimide. Someone brought the topic up on lycaeum and noone had a clue over there either:\
 
Let's face it. the Japanese smart-shops sell all manner of exotics. I expect, though, that the pill makers (The Yakusa I assume) have s much morals as the US & European makers. As long as the pills do SOMETHING then they sell them.
 
I guess that's the case, I'm just curious about WHAT they are doing. Can't be good though..
 
That doesn't look like it was there intentionally(well intentionally for any form of recreational effect), can't imagine it having any effects which are not toxic or nasty.

That just looks like a very serious & harmful mistake/error.
 
is it possible that there was a synthesis error? I dont know much about structure of compounds but were they trying to synth a psychoactive substance and got this? Maybe we should look at the possible precursor in the pill, is it a relative of anything recreational? I dont think a synther would know or care if they made a mistake ala mppp/mptp
 
^ It appears to not be such a mistake from inferring such with the precursor apparently present in the small amount that might well be expected in such a manufacture

Assumably if there was anything else in the pills it would be noted so where they stumbled on this is anyone's guess...and whether it is actually worth a crap or not ....
 
Not a single hit with pharmacological properties using SciFinder, no patents either. Is this stuff researched at all?! I get 9 papers, all dealing with synth and/or structure somehow but nothing useful. Caution is advised...
 
The phthalimide would cleave in the body to give 2,4,6 trimethylphenylethylamine, if that's any help to anyone. I'm not sure whether you guys knew that or not, so forgive me if I am stating the obvious.
 
I had a red S pill like that. Double dropped and it was definitely weak, but it kept me up all night. I suspected it was Speed/Meth, but it was on the weak side as far as euphoria went and just kept me up.
 
IlostaMadge said:
The phthalimide would cleave in the body to give 2,4,6 trimethylphenylethylamine, if that's any help to anyone. I'm not sure whether you guys knew that or not, so forgive me if I am stating the obvious.
Click to expand...

It will be cleaved, but won produce 2,4,6-trimethylphenylethylamine since it is not N-(2,4,6-trimethylphenethyl)pthalimide. Instead it gives 2,4,6-trimethylaniline :X (and aromatic amine doesnt sound so good)
 
Pomzazed said:
It will be cleaved, but won produce 2,4,6-trimethylphenylethylamine since it is not N-(2,4,6-trimethylphenethyl)pthalimide. Instead it gives 2,4,6-trimethylaniline :X (and aromatic amine doesnt sound so good)
Click to expand...

And especially if its as electronrich as this with all the methyls (check out the Toluidins and Anisidins,nasty stuff!I hope its labeled wrong and is in reality Phtalimidoethyl-hemellitol (the protected phenethylamine and not the aniline...)
 
^ AOn top of that, the aniline derivatives hugo mentioned also are hepatotoxic and cause methaemoglobia - they bind to the haemoglobin in red cells, preventing it from carrying oxygen throughout the body.

Wouldn't touch it personally with a shitty atick...
 
hugo is right about the methyls.
Whoops... aniline itself is enough toxic, with electron donators like this it would be even more reactive.
 
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