Painiac512
Bluelighter
Okay, after many moons on and off Opana, I finally got busted abusing my script. It was my own fault, of course. But that's a story for a different thread.
He finally, after much begging, pleading and promising, agreed to put me on the 50mcg Fentanyl patch, specifically Mylan brand (apparently difficult to abuse and have the lowest amount of actual fentanyl inside). Naturally, I have set about reading and researching just how I can abuse these/use these to their fullest potential...
So far, it seems consistent that the transdermal ROA shows about 90% bioavailability. This is quite good. Three factors can be controlled by the user to increase the rate at which the drug is absorbed. These are, in order of both importance and ease of application/control: heat, local skin pH at time of application, and possibly vaso-dilation by chemical means.
The last one isn't conclusively tested to be true; it simply stands to reason that if skin capillaries can be expanded their surface area, through which the drug must pass, is both increased while its density is decreased (making for greater permeability). Lots of vasodilator drugs out there, and most of them safe in many circumstances. One could even do a local vasodilation at the site of the patch placement by application of ...HEAT! What a segue for the next paragraph!
The first one is universally true for all transdermal drugs; there's huge amounts of research not to mention the bold warnings included with the drug regarding just how heat can lead to a fatal overdose. Heat can be controlled by local radiant sources (hot water, heating pad, The Sun). It can also be internally produced, via a fever or perhaps a pyrogenic drug. Let's say, endotoxin maybe? Not really. That's a bad one. Still, there's hundreds, maybe even thousands, of medications that will cause a mild fever in most patients. Chances are, at least one of them might be safe for your system and just put you at a toasty 100F. Now, giving yourself an intentional fever just to get your fentanyl in your body faster is probably on the side of Most Stupid, perhaps even a candidate for a future Darwin Award.
The second one, though, is just plain interesting. My wife, who is a biologist and studies actively as she teaches, confirms that biological membranes, both animal and plant, of pretty much all kinds (mucus, buccousal, etc.) will have a 'sweet spot' pH level for any specific chemical to be most transparent to. This would obviously be different for each chemical, and very probably a little different for each individual (though I suspect not by much, as we are all pretty close to identical--chemically at least). I read much consistently worded reports that a thin film of plain soap (not body wash, or any other such shit) remaining on the dried skin prior to application also produced faster absorbtion. Soap is generally very high pH (around 10 for non pH-balanced products is typical). Human skin is fairly neutral, averaging around 5.5 for my ethnicity, but fluctuating values of 4.5 to 6 can be found throughout the species.
So, here's my plan. I'm going to go have a nice, hot shower wherein I'll debride some patch of healthy looking skin while washing all over with this bar of Dial, which has a pH of about 11 from the look of the test strip. I'll take the pyrogen (not saying which one--pick your own!) right now so as to get some immediate effect when I finally apply the patch, in about an hour. After carefully ensuring that there's soap on the skin, I'm going to read a few chapters of a decent novel while I air dry. I leave the visuals to your imaginations, good readers. Be kind.
Once prepared and soapy-dry skinned, I'll apply the patch as directed, 'ironing' it for a good 60 seconds to ensure decent adhesion to an uncertain surface. Then, I plan to remove the other soapy residue. It won't affect skin pH beyond its immediate topical application anyway. Plus, it's going to get in the way of the next step: sealing the little bastard down.
A couple of years ago, an orthoscopic surgery of my hip introduced skin-borne bacteria into the site of the surgery. Four months later, I had an amazing abscess. The thing hurt for quite some time before I thought there was anything wrong other than a still-injured hip (both from the accident and surgery). It was when I had taken a major dose of Opana (about 160mg) and still felt huge pain that I noticed it was a bigger problem. They drained over 2 liters of necrotic material and removed my gluteus minimus, as well as a piece of the gluteus maximus. Just one side, at least. My recovery was aided by the Ever-Cursed WoundVac. That damn machine permitted the wound to close and heal about twice as fast as if it were done naturally. I hated it because it was a constant, sucking PAIN IN MY ASS for three and a half months. And every other day, the dressing had to be changed, which left me with hundreds of sheets of vacuum-tight super-adhesive plastic bandages with which I can cut and 'seal' in the patch. These have two benefits for me. First, they're particularly good at holding in perspiration. I noticed this every time it was changed on my butt. They're a lot like the 'Tega-derm' bandages. Second, by preventing any respiration they're going to help maintain that artificial skin pH I created with the soap. At least that's the plan.
Also, I'm going to try vasodilator drugs. I've got a few here. Again, no names! These were prescribed to me, so I do know how they work on ME at least. That doesn't mean I know what they'll do to you though! Maybe for safety this particular component could be done via ultra-short acting vasodilators, like nitroglycerin or something. That way normal blood pressure would resume in like 30 minutes or so (in most circumstances), and capillary diameter would return to normal as well. I have nitro here, also medically (I take Xyrem for narcolepsy; Xyrem creates a dopamine rush at the end of its metabolism, which in most patients results in a temporary increase in blood pressure; my BP is okay, usually, but the Xyrem/dopamine combo really does create an event that needs treatment with something like nitroglycerin from time to time).
Finally, I'm going to use local heat via an electric heating pad. This I'll do as long as I can tolerate it. There's no very good information of just how much acceleration heat will create. Nothing consistent at least.
I know much of this has been discussed and shouted about in many other threads. I hoped to make this one at least somewhat novel by incorporating as much information as I could and as many theories as I dared. I'll report back later my experiences with all these things combined. I've also got a great summary to blurt out about my recent experience with BuTrans...but that's going to be a long post.
Maybe a REALLY long post.
Painiac
He finally, after much begging, pleading and promising, agreed to put me on the 50mcg Fentanyl patch, specifically Mylan brand (apparently difficult to abuse and have the lowest amount of actual fentanyl inside). Naturally, I have set about reading and researching just how I can abuse these/use these to their fullest potential...
So far, it seems consistent that the transdermal ROA shows about 90% bioavailability. This is quite good. Three factors can be controlled by the user to increase the rate at which the drug is absorbed. These are, in order of both importance and ease of application/control: heat, local skin pH at time of application, and possibly vaso-dilation by chemical means.
The last one isn't conclusively tested to be true; it simply stands to reason that if skin capillaries can be expanded their surface area, through which the drug must pass, is both increased while its density is decreased (making for greater permeability). Lots of vasodilator drugs out there, and most of them safe in many circumstances. One could even do a local vasodilation at the site of the patch placement by application of ...HEAT! What a segue for the next paragraph!
The first one is universally true for all transdermal drugs; there's huge amounts of research not to mention the bold warnings included with the drug regarding just how heat can lead to a fatal overdose. Heat can be controlled by local radiant sources (hot water, heating pad, The Sun). It can also be internally produced, via a fever or perhaps a pyrogenic drug. Let's say, endotoxin maybe? Not really. That's a bad one. Still, there's hundreds, maybe even thousands, of medications that will cause a mild fever in most patients. Chances are, at least one of them might be safe for your system and just put you at a toasty 100F. Now, giving yourself an intentional fever just to get your fentanyl in your body faster is probably on the side of Most Stupid, perhaps even a candidate for a future Darwin Award.
The second one, though, is just plain interesting. My wife, who is a biologist and studies actively as she teaches, confirms that biological membranes, both animal and plant, of pretty much all kinds (mucus, buccousal, etc.) will have a 'sweet spot' pH level for any specific chemical to be most transparent to. This would obviously be different for each chemical, and very probably a little different for each individual (though I suspect not by much, as we are all pretty close to identical--chemically at least). I read much consistently worded reports that a thin film of plain soap (not body wash, or any other such shit) remaining on the dried skin prior to application also produced faster absorbtion. Soap is generally very high pH (around 10 for non pH-balanced products is typical). Human skin is fairly neutral, averaging around 5.5 for my ethnicity, but fluctuating values of 4.5 to 6 can be found throughout the species.
So, here's my plan. I'm going to go have a nice, hot shower wherein I'll debride some patch of healthy looking skin while washing all over with this bar of Dial, which has a pH of about 11 from the look of the test strip. I'll take the pyrogen (not saying which one--pick your own!) right now so as to get some immediate effect when I finally apply the patch, in about an hour. After carefully ensuring that there's soap on the skin, I'm going to read a few chapters of a decent novel while I air dry. I leave the visuals to your imaginations, good readers. Be kind.
Once prepared and soapy-dry skinned, I'll apply the patch as directed, 'ironing' it for a good 60 seconds to ensure decent adhesion to an uncertain surface. Then, I plan to remove the other soapy residue. It won't affect skin pH beyond its immediate topical application anyway. Plus, it's going to get in the way of the next step: sealing the little bastard down.
A couple of years ago, an orthoscopic surgery of my hip introduced skin-borne bacteria into the site of the surgery. Four months later, I had an amazing abscess. The thing hurt for quite some time before I thought there was anything wrong other than a still-injured hip (both from the accident and surgery). It was when I had taken a major dose of Opana (about 160mg) and still felt huge pain that I noticed it was a bigger problem. They drained over 2 liters of necrotic material and removed my gluteus minimus, as well as a piece of the gluteus maximus. Just one side, at least. My recovery was aided by the Ever-Cursed WoundVac. That damn machine permitted the wound to close and heal about twice as fast as if it were done naturally. I hated it because it was a constant, sucking PAIN IN MY ASS for three and a half months. And every other day, the dressing had to be changed, which left me with hundreds of sheets of vacuum-tight super-adhesive plastic bandages with which I can cut and 'seal' in the patch. These have two benefits for me. First, they're particularly good at holding in perspiration. I noticed this every time it was changed on my butt. They're a lot like the 'Tega-derm' bandages. Second, by preventing any respiration they're going to help maintain that artificial skin pH I created with the soap. At least that's the plan.
Also, I'm going to try vasodilator drugs. I've got a few here. Again, no names! These were prescribed to me, so I do know how they work on ME at least. That doesn't mean I know what they'll do to you though! Maybe for safety this particular component could be done via ultra-short acting vasodilators, like nitroglycerin or something. That way normal blood pressure would resume in like 30 minutes or so (in most circumstances), and capillary diameter would return to normal as well. I have nitro here, also medically (I take Xyrem for narcolepsy; Xyrem creates a dopamine rush at the end of its metabolism, which in most patients results in a temporary increase in blood pressure; my BP is okay, usually, but the Xyrem/dopamine combo really does create an event that needs treatment with something like nitroglycerin from time to time).
Finally, I'm going to use local heat via an electric heating pad. This I'll do as long as I can tolerate it. There's no very good information of just how much acceleration heat will create. Nothing consistent at least.
I know much of this has been discussed and shouted about in many other threads. I hoped to make this one at least somewhat novel by incorporating as much information as I could and as many theories as I dared. I'll report back later my experiences with all these things combined. I've also got a great summary to blurt out about my recent experience with BuTrans...but that's going to be a long post.
Maybe a REALLY long post.
Painiac
