Misc My quitting opiates magic bullet.

[thurston]

I have chronic pain and use grey market opiates for pain. I usually take them until they stop working, take a week off work and withdraw to reset tolerance about twice a year. The last two runs have been Tianeptine and I happened to being sitting on prescriptions for methylprednisolone. The methylprednisolone elleminates 80% of my WD aches and pains with very little watery eyes.

 

[Opana313]

Interesting..it seems with a simple search that this prescription seems to be used for many conditions, so I guess it doesn't surprise me that it may help a bit but I wish I knew more.

Does it help with the psychological effects?

Or the fatigue/no sleep?

Also curious does it help with anxiety and/or cravings?

Do you think it's a great tool for withdrawal and trying to go about your day to day life, work etc.?

 

[thurston]

It helps by reducing the inflammation associated with wd. I have chronic inflammation so my body pain is brutal during wd. I don't take opiates to get high any more so I don't get that craving, the only craving I have during wd is for it to be over.

Edit

I'm on day 2 of no Tianeptine. I generally take 3 sometimes 4 50 mg pills a day. It doesn't help with anxiety it would probably make it worse because prednisone makes me pretty jittery. I have a script for gabapentin and klonapin to take care of that.


I would like to note that I've had a really bad sinus infection lately that's why I had a script for prednisone. They're easy to get.

Edit2: im at work today and haven't taken any gabapentin or klonapin for comfort and im not feeling bad except for the sinus infection. I'm actually very happy with that easy withdrawal, I've been dreading having to go through it and had already scheduled a week off work next month for the occasion. I'll actually get to do something fun that week instead of being dope sick.

 

[daturetard]

I'd just like to add that tieneptine is not just any opioid but the antidepressant effects of it make for a pretty horrific combined withdrawal like that of tramadol or other dirty opioids. If you can get literally anything else grey market, I'd suggest a switch. Does kratom do the trick for you? (As in help with your pain).

 

[aftershocknrock]

is that not a steroid? i would defo not recomend self medicating with steroids for opioid WD they can have pretty dire side effects. while effective for hyperalgesia during WD our gabbas and clonazapam will be helping significantly with wds

 

[vision conquest]

Prednisone is essentially synthetic cortisol if I'm not mistaken, so yes it is a steroidal anti-inflammatory.
Using it short term usually doesn't cause problems, however definitely not something you want to stay on for long.

This is very interesting, I remember reading an article on the actual cause of opioid wd and it is basically a pro-inflammatory cytokine storm, so it makes sense that a strong anti-inflammatory would help.

 

[aftershocknrock]

Prednisone is essentially synthetic cortisol if I'm not mistaken, so yes it is a steroidal antiinflamatory.
Using it short term usually doesn't cause problems, however definitely not something you want to stay on for long.

This is very interesting, I remember reading an article on the actual cause of opioid wd and it is basically a proinflamatory cytokine storm, so it makes sense that a strong antiinflamatory would help.

yeah i recall reading similar but its not clear (i think) if the cytokine storm and inflamatory response is the root cause of wd symptoms or a link in a chain of downstream signaling

 

[thurston]

I'd just like to add that tieneptine is not just any opioid but the antidepressant effects of it make for a pretty horrific combined withdrawal like that of tramadol or other dirty opioids. If you can get literally anything else grey market, I'd suggest a switch. Does kratom do the trick for you? (As in help with your pain).

I find Tianeptine more effective than kratom, kratom WD for me can get pretty bad. I am pretty disciplined with my dosing now a days so my dosage doesn't get out of hand.

 

[thurston]

Prednisone is essentially synthetic cortisol if I'm not mistaken, so yes it is a steroidal anti-inflammatory.
Using it short term usually doesn't cause problems, however definitely not something you want to stay on for long.

This is very interesting, I remember reading an article on the actual cause of opioid wd and it is basically a pro-inflammatory cytokine storm, so it makes sense that a strong anti-inflammatory would help.

I only have 5 days worth, it was prescribed for a sinus infection I currently have along with an antibiotic.

 

[Allylbenzene]

Agmatine is worth looking into for reducing withdrawals and general anti-addiction purposes. It's an OTC supplement and naturally produced substance.
There are several papers talking about agmatine helping with opioid issues. Here's one:

Systemically or centrally administered agmatine prevents, moderates, or reverses opioid-induced tolerance and self-administration

https://pmc.ncbi.nlm.nih.gov/articles/PMC2775255/

Prednisone is essentially synthetic cortisol if I'm not mistaken, so yes it is a steroidal anti-inflammatory.

Do you think it's a great tool for withdrawal and trying to go about your day to day life, work etc.?

Considering methyl-prednisolone is essentially an analogue of the stress hormone cortisol, I'd say it's not something that will help to stop any drug. The ideal supportive strategy is to reduce stress and reduce it's effects (eg agmatine does exactly that).

 

[WellTram]

Would dexamethasone be as good for WD ( pre - Jump And post - jumping off of them ? Pain ?
I noticed dexamethasone pills Are ONLY 4 mg, my methylprednisolone are 16mg pills. Any experience with dexamethasone?

 

[Allylbenzene]

Would dexamethasone be as good for WD ( pre - Jump And post - jumping off of them ? Pain ?
I noticed dexamethasone pills Are ONLY 4 mg, my methylprednisolone are 16mg pills. Any experience with dexamethasone?

IMO none of the the hormones that behave like the stress hormone are beneficial for WD.
Using them for pain relief is counterproductive since it makes things worse in the long-term.
One of the main goals to support withdrawal symptoms is to minimise stress & reduce adrenaline (clonidine does this).
Stress and adrenaline are partly responsible for WD, so using hormones that mimic the stress hormone is not the best idea.

Here is a list of OTC options for supporting opioid detox/WD, including how to REPAIR things.
They will be most effective when used together.
None of these cause the side-effects associated with synthetic stress-type hormones like methylprednisolone or dexamethasone.

• Theanine = anti-stress, anti-adrenaline, anti-anxiety, anti-insomnia
• Agmatine
• magnolol & honokiol - use a 90%+ standardised extract = anti-stress, anti-adrenaline, anti-anxiety, anti-insomnia

Agmatine is used to reduce withdrawals and prevent tolerance build-up for stimulant, opioids, benzos and alcohol.
Theanine and magnolol/honokiol are potent GABAergics.

• Thymoquinone extract (reduces opioid withdrawals)
• Sodium ascorbate (reduces heroin withdrawals)
• Curcumin (attenuates opioid tolerance, dependence, and morphine withdrawal)
• Clove (facilitates the de-addiction of opiates) - probably due to eugenol & caryophyllene
• Linalool (morphine tolerance and dependence)
• Creatine (reduces withdrawals)

Opioid-sparing items that don't activate the mu-opioid receptor.

• Caryophyllene
• Cannabigerol
• Myrrh oil
• Menthol
• Vanillin
• Myrcene
• Pinene

The other side to this appoach is restoring the body's natural ability to regulate stress, make energy and produce dopamine.
This is achieved by restoring proper thyroid function and mitochondria (see this post on what they are and why they're worth repairing)

• Vitamin B1 (via B-complex)
• Niacinamide (50-100mg, with meals)
• Low dose aspirin (81-100mg max per day, why aspirin?)
• L-Phenylalanine (300-500mg, daily)
• Creatine (1g daily)
• CoQ10
• Ribose
• Inosine
• Rhodiola rosea (adaptogen)
• Coffee (+ honey + theanine) - why honey? this post explains how to use it sustainably to avoid negative-reactions (shakes, jitters, anxiety)
  

  The caffeine in coffee is powerful and can act like thyroid to increase your metabolic rate and the oxidation of sugar, making it a health-protective food.
  Symptoms to expect when you do coffee right are calmness, focus, motivation, warmth, and stable energy.

Repairing mitochondria improves the production of energy and the production of protective steroid hormones.
Both energy and steroids are needed to handle stress adaptively.