not that i get come-up anxiety each time i trip, but if i do get it on LSD, mushrooms or 4acodmt, i like to move around. or even just change the room i'm in / change the music.
with 2ce or 2cb i feel i don't get much anxiety on the come-up, but the come-up makes me feel a bit ill. to combat this, i think it's better to lay relatively still. and take a shower right before it kicks in. and THEN go for a walk.