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MXE vs. Ketamine

Foreigner

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There are some unanswered questions about MXE/Ketamine comparisons on the internet. I think this is due to MXE being a relatively new substance.

The empirical defining differences between MXE and ketamine are the dosing level and the length of the high. MXE is active at lower doses and the high lasts significantly longer than ketamine. Other comparisons are more subjective (listed below), but may still prove useful.

This thread assumes that you are dealing with one or the other, not both mixed together or with any other adulterants. Missing info is labeled accordingly below. Please do not assume it is complete or correct, I am posting it here for discussion. This OP will be edited as more accurate info is gathered.

Taste:
MXE - metallic, micro-doses under tongue more likely to numb mouth; some say it is more aromatic ("perfume"-like quality)
Ketamine - bitter, cold, minty, hairspray-like taste

Dose:
Ketamine - 20mg = threshold
MXE - 20mg = you're high
Ketamine - 5mg = usually very minor effects
MXE - 5mg = high can be felt, and is lasting

Length of high:
Ketamine - 1 hour with 1-3 hour after effect
MXE - 2-4 hours with after effects lasting days
- more people report an extended hangover effect from MXE than ketamine, but negative after effects are possible with both

Common forms:
Ketamine - crystal or powder
MXE - almost always powder
- ketamine is usually derived from evaporating its liquid state until solid crystals are left behind; MXE is never in a liquid state and thus is universally in powder form

Colour:
Ketamine - white
MXE - white, or off white-tan

Effects:
MXE - motor function impaired but movement possible, even at higher doses; some people report being able to move during an m-hole
Ketamine - less motor function, even ataxia, movement impossible in a k-hole

Burn test:
Ketamine - burns to an oily red
MXE - ?

Dissolvability in water @ standard pressure, and room temperature:
Ketamine - 150mg/ml max
MXE - 150mg/ml max
- both require the addition of heat for complete dissolution

Heavier doses:
Ketamine - can k-hole completely
MXE - m-hole not guaranteed, some people achieve it while others can't

Other:
- both drugs share cross-tolerance (if you become tolerant to one you will become tolerant to the other)
- both are NMDA antagonists and non-competitive allosteric modulators, but MXE acts as a reuptake inhibitor of serotonin which accounts for subjective reports of it feeling warmer than ketamine
- the warmth felt from either can be due to less ion channel blockage (i.e. you simply feel the cold less), or from reuptake activity similar to classical anti-depressants (a feature more strong in MXE)
- overdosing on ketamine is rare, but on MXE it's possible due to equivalent amounts of MXE producing a more drastic, longer lasting high
- both can generate spiritual experiences, but subjective reports say that ketamine highs tend to be more lucid and stable than MXE

Please feel free to post more experiences or empirical knowledge, and I will update this post accordingly.
 
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Ketamine's solubility in water is not what I would call "complete".

MXE is about 150 mg/ml max, ketamine is about the same.
 
yeah ketamine is water soluble but not as soluble as say cocaine or heroin. I'd say .2 dissolves in 1ml (200mg ketamine for 1 gram water), not exactly the most soluble drug on the market.

never done mxe though. I'm really into kholing so if I'm gonna do anything it's gonna be k. I dont thin being fucked up for 4 hours and hungover for days would be fun at all. that sounds like shit
 
You definatly hole with mxe, its just not always guaranteed like with ketamine, you have to work with it though to hole or a hit of weed usually help, but the hole can be better imo and can last as long as 40 minutes which is pretty much the length of the total ketamine experience. I wouldnt call it a hangover it more like a happy afterglow, theres nothing negatve about like with a hangover. As for the color, yea there is powdered mxe which is usually almost completely inactive or can be pretty good, but best mxe out is bright shiney white salt like mini crystals, like the kind on a pretzel that stuff is beautiful. Theres also an off white yellowish sandy kind floating around thats not to great.
 
would you recommend trying mxe out while it's still legal? I was always curious but I figured it wouldn't stand up to a .2g ketamine shot. will my huge k tolerance cross over to mxe?
 
^ I would ;)

And of course you can hole with MXE, as taco bell said.

Another thing to add: MXE is completely water-soluble.
 
where are you lot getting this hangover with methoxetamine ? i was in at the very start with it to using up to just before the ban and not once did i get a hangover . love the fact that its not over in an hour and that it really can mend a broken person . only done ket a couple of times and would not waste my money on it if i knew i could get mxe . plus mixing mxe with stims is a whole new world you see time dripping off your finger tips holes in the sky and watch you self melt away just to be rebuilt in tiny little blocks piece by piece
 
would you recommend trying mxe out while it's still legal? I was always curious but I figured it wouldn't stand up to a .2g ketamine shot. will my huge k tolerance cross over to mxe?

Yea you might as well, the k tolerance will cross over to mxe you'll probably need to do a pretty big dose to get where you're trying to go, normal doses will probably just give you the wacky stimulant effects of mxe.
 
length of high 2 - 4 hours ?

its been a long time since i had any but wouldnt it be more like 4 - 6 ? or maybe even 6 - 8 ?

and is the word 'spiritual' appropriate here ? i would say thats more to do with the user than the chemical itself.
some of us dont even believe we have a 'spirit' regardless of what / how many drugs we've done.....not trying to widen the discussion or start a debate....just think if you're trying to create something useful or factual then that word should be replaced or removed....with all due respek n all that

i also found the taste of MXE varied....some tasted very much like K whereas some had a more perfumey taste....the prefumey stuff was way trippier....i read and re-read countless times that the effects couldnt vary from batch to batch but IME it did
K always has a 'burnt' taste to it IMO
 
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I always felt like mxe was a lot more toxic than k. I'd k-hole over doing mxe any day.
 
Pharmacology:

Ketamine: it is pretty selective for NMDA antagonism (noncompetitive allosteric modulation). Auxiliary activities at other sites are too minor to account for behavioral effects.

MXE: NMDA antagonist (noncompetitive allosteric modulator), but also with significant affinity at SERT (likely action as a reuptake inhibitor).

Oddly absent is binding at any sigma receptor, along with any previously speculated dopaminergic action or opioid activity.

ebola
 
Ketamine is definitely a local anesthetic; it's prescribed as a 10% topical gel in petrolatum sometimes for pain, i thought. How do you explain this if it's not from NMDA antagonism (which as far as I can tell is not anesthetic itself). The local anethesia from K/MXE definitely 'feels' like Na channel blockade, like from lidocaine, but ketamine is probably 5-10 times stronger at producing it.

I have always believed that the subjective differences betwen K and MXE involved blockade of one or more of Na, K, Ca channels. I would assume that this also plays a role in the more 'complex' nature of the K high... greater inhibition of Na channels = less sensory input = better dissociation. But, I don't think it's ever been assayed? The ECMD study was only on G-protien receptors, I thought.
 
^ So they both have a numbing effect in the mouth, but K is stronger (according to what you just said). What about warmth? That seems to be a trait of MXE, even at very small doses, whereas K does not produce much warmth AFAIK.

If true, I don't get how MXE produces warmth but K doesn't, given that it's an analog.
 
"Warmth" is such a subjective term.... it could be attributed to the lack of 'cold'-ness from less ion-channel blockade, or it could be from the SERT activity (i.e. a bit like a classical antidepressant)
 
I haven't heard much about Na channel blockers being psychoactive when taken alone. It looks like there are some variants that are expressed centrally (many, actually), so it seems plausible. And it also looks like ketamine exhibits such activity, but I'm not sure at what potency. Interesting...

ebola
 
MXE dehydrates me far worse than ketamine, and does have a hangover of sorts, partly due to it dehydrating me so much, and just feels harder on the body overall. I never got this "afterglow" people speak of. And for me, yeah 2-4 hours sounds about right for the primary effects. The " hole" was always less spectacular than k as well, as its intrinsic stimulation kept me me more in touch with the outside world. That said, I could always fall asleep fairly easily 3 hours after an 80mg IM shot. At these higher levels I vastly preferred ketamine. For me MXE really shined in low doses sublingually, like 10-25 mg, something ketamine wasn't capable of. I used to enjoy ketamine orally, but the doses were prohibitively high, and still paled in comparison to 150-200 mg IM. They both are certainly NMDA antagonists, but quite a bit different, more so than expected.
 
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I think the original post is inaccurate in that it states MXE has a hangover that can last days? Really? I don't find that the case at all. MXE to me lasts initially 4 to 5 hours, with a come down of an addition 4 to 5 hours. It's a lengthy high for sure.

Ketamine to me is more debilitating in that I can't move, or rather I don't want to. It makes me feel sick and I have to lay down to even come close to enjoying my high. It's really quite senseless and stupid feeling as oppose to Methoxetamine which to me feels like a whole new level, extremely cosmic and inward psychedelic type of high. My tolerant for MXE is really high, I need at least 100mg to feel anything. However when I first started doing it, those lower level doses around 35 to 40mg were pure magic, something I'm no longer able to recreate due to a tolerance.

Also, I'd no longer ever consider doing ketamine again, unless it was given to me for free :P
 
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