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MXE & Tryptophan

E

etasu

Bluelighter
Joined
Jun 11, 2012
Messages
59
I seem to be really confused about where posts about supplements should go...
Does anyone have experience with daily MXE & tryptophan?
This is what I ordered: *unnecessary link to L-tryptophan source... tryptophan is tryptophan*
 
Last edited by a moderator:
It's not the worst contraindication in the world but I would advise that you stop taking the tryptophan in the days prior to using MXE.
There seem to be a few reports of people having bad reactions on 5-htp + MXE so I'd approach tryptophan+MXE with similar caution.
 
Are there more studies about MXE working as an SRI? Because for the longest time I heard it was a DRI but indirectly affected serotonin to an extent?
 
JarBag said:
Are there more studies about MXE working as an SRI? Because for the longest time I heard it was a DRI but indirectly affected serotonin to an extent?
Click to expand...

In the MXE addiction subthread there is a post claiming that MXE is not a DRI: http://www.bluelight.ru/vb/threads/...-Addiction?p=11403196&viewfull=1#post11403196

The post in the MXE addiction subthread links to this other post with more detail: http://www.bluelight.ru/vb/threads/649843-Binding-data-for-popular-arylcyclohexamines
 
Toucan said:
It's not the worst contraindication in the world but I would advise that you stop taking the tryptophan in the days prior to using MXE.
There seem to be a few reports of people having bad reactions on 5-htp + MXE so I'd approach tryptophan+MXE with similar caution.
Click to expand...

What are the nature of these bad experiences? Subjective and/or objective effects?
 
Tryptophan and 5-HTP have limited application anyway so it should not be too problematic to discontinue it.

Can't say I am too surprised this can cause problems because serotonergic drugs (at least a number of things other than partial 5-HT2a agonists) can potentially be an issue with MXE.

You use both MXE and L-tryptophan daily??

to clear something up said:
Yes discussion of it fits here because of the MXE which is covered under psychedelic discussion - the supplement part is not the main designator of the topic - in any case supplement discussion goes in Healthy Living, apart from Nootropic discussion which goes here and Steriod discussion which has it's own forum
Click to expand...
 
At the time of my original post I had no experience with Tryptophan. However now I take it multiple times daily, including the days I use MXE, and noticed no bad effects.
 
The rate limiting step for synthesis of 5-ht is hydroxylation of tryptophan, and AFAIK the pathway is realtively easily saturated - taking a bolus dose of tryptophan poses no more risk for serotonin syndrome than eating a turkey sandwich does.

Taking 5-HTP is another thing entirely.
 
sekio said:
The rate limiting step for synthesis of 5-ht is hydroxylation of tryptophan, and AFAIK the pathway is realtively easily saturated - taking a bolus dose of tryptophan poses no more risk for serotonin syndrome than eating a turkey sandwich does.

Taking 5-HTP is another thing entirely.
Click to expand...

Glad to have someone confirm this, as it was what I was suspecting when I decided to buy tryptophan instead of 5htp.
 
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