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  • BDD Moderators: Keif’ Richards

Opioids MS Contin XR Morphine

P

pnillyg

Bluelighter
Joined
May 3, 2024
Messages
823
Does anybody know the best way to use MS XR morphine tablets (15mg)? The bioavailability is super low so I’m wondering the best ROA ex. CWE or plugged? Also if somebody could point me toward the meat poppy seed tea recipes that would be awesome. Much love
 
I would crush them, put the crushed powder in 3 to 5 ml of slightly acidic water (add some citric acid or vinegar), then let it sit for 8+ hours and plugg everything except the gunk that doesn’t dissolve on the bottom. After rinsing the gunk three times and plugging those rinses, I would swallow it to get out any last bit.
 
paranoid android said:
You can just seperate the gell from the ms with heat then plug it. Just cook it up like your doing a shot, scrape off the gell, let it cool then plug it.
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fairnymph said:
I would crush them, put the crushed powder in 3 to 5 ml of slightly acidic water (add some citric acid or vinegar), then let it sit for 8+ hours and plugg everything except the gunk that doesn’t dissolve on the bottom. After rinsing the gunk three times and plugging those rinses, I would swallow it to get out any last bit.
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Would the gel/gunk be the dark blue coating or would it be some fillers or both? I’ve never done a shot I’ve only ever crushed and plugged OC before so don’t really know the heating nesthod. Is there any in depth process I could check out that yall would know? Don’t wanna screw it up as I only have a few ! Thanks for the help!
 
pnillyg said:
Would the gel/gunk be the dark blue coating or would it be some fillers or both? I’ve never done a shot I’ve only ever crushed and plugged OC before so don’t really know the heating nesthod. Is there any in depth process I could check out that yall would know? Don’t wanna screw it up as I only have a few ! Thanks for the help!
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You gotta scrape the coating off frst. You can do that with a razor blade with any mscontin ive had
 
pnillyg said:
Would the gel/gunk be the dark blue coating or would it be some fillers or both? I’ve never done a shot I’ve only ever crushed and plugged OC before so don’t really know the heating nesthod. Is there any in depth process I could check out that yall would know? Don’t wanna screw it up as I only have a few ! Thanks for the help!
Click to expand...
I have not dealt with anything like this, so I’m going to defer to @paranoid android

But any tablets that don’t have a gel or wax coating can be dealt with in the manner I mentioned previously (and if they’re too hard to crush, you can just let time do the work generally).
 
fairnymph said:
I have not dealt with anything like this, so I’m going to defer to @paranoid android

But any tablets that don’t have a gel or wax coating can be dealt with in the manner I mentioned previously (and if they’re too hard to crush, you can just let time do the work generally).
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The problem with mscontin is that they have a wax matrix which you need to defeat with heat. There are other ways to do it with solvents but thats beyond me really
 
Ok so scrape the coating the crust the inside and heat it up in some water until ideally what’s left is the active opiates. Boil the water or just simmer? Thank you
 
pnillyg said:
Ok so scrape the coating the crust the inside and heat it up in some water until ideally what’s left is the active opiates. Boil the water or just simmer? Thank you
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I imagine you use just enough heat to see it separate into two layers, waxy and aqueous, so probably a simmer is best. You definitely don’t want it to be boiling so hard it’s splattering all over the place.
 
That sounds like the morphine in capsules with tiny balls of the medication inside. You are correct however MS contin is supplied as a tablet in some other countries. As someone who has seen a sibling struggle to convert from capsules to pills, I can say that the bioavailability once prepared for IV, of the tablets is much lower than the capsules, and the preparation very different in both time and methods.
 
fairnymph said:
I imagine you use just enough heat to see it separate into two layers, waxy and aqueous, so probably a simmer is best. You definitely don’t want it to be boiling so hard it’s splattering all over the place.
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If you refer to the capsule form, it is helpful to put the solution in the fridge or freezer once you're done with all prior steps because it allows you to get rid of more of the separated wax.
 
UK get tablet crush then they are millions tiny pellet balls just crush them between 2 bits of greaseproof paper till powder then take as your preferred method oral I'm IV I just eat it in powder form and it's magic
 
Honestly mscontin is one of my favorite things for long lasting pain issues. Seriously not many would say it but it works for me. All I did was chew the pills up real good making sure the stuff that would "gel" between teeth was freed by a toothpick. Usually started "feeling" it in 15 to 20 minutes and last all day. Just me and my pain issues, though. Everyones milage may vary
 
Have you guys ever did Mallinckrodt Exalgo? ER Hydromorphone 8mg, 16mg, 24mg, 32mg.

Let your saliva do the trick by 15 mins in the mouth. Then your teeth can split in half. One side is bind and the other high purity "brand name" Hydromorphone. The good side dissolves buccal like no other. The "rush" or "delivery" keeps happening for 40 mins with the 32mg ones. I had this Rx and did it too often and had to switch. It hurts badly the teeth unlike Oxycodone dissolved under the tongue.
 
Them Witches said:
Have you guys ever did Mallinckrodt Exalgo? ER Hydromorphone 8mg, 16mg, 24mg, 32mg.

Let your saliva do the trick by 15 mins in the mouth. Then your teeth can split in half. One side is bind and the other high purity "brand name" Hydromorphone. The good side dissolves buccal like no other. The "rush" or "delivery" keeps happening for 40 mins with the 32mg ones. I had this Rx and did it too often and had to switch. It hurts badly the teeth unlike Oxycodone dissolved under the tongue.
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never tried them but always testing research wise.looking at sources now.
 
gmanzalready1 said:
never tried them but always testing research wise.looking at sources now.
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10-4... They are supposed to be 1 dose per 24hrs. Mallinckrodt's "Brand-Name Exalgo" is 100% high purity, top tier quality Hydromorphone HCl, and the brand-name Exalgo was discontinued in the United States in 2017. Mallinckrodt was served with a subpoena from the U.S. Department of Justice concerning its promotional practices for the product, and subsequently stopped marketing it. Despite the brand's discontinuation, the generic version is still available in the same "pill construction model." Mallinckrodt lists hydromorphone extended-release tablets as part of its generic product portfolio.

Mallinckrodt is described as a company that manufactures generic and "non-promoted" branded opioids. This means that while some brand-name drugs may still be sold under its legacy portfolio, they are not actively promoted to prescribers. Outside of the U.S. I am 95% sure that Mallinckrodt still sells the "brand-name Exalgo" and the "generic version.

I do not remember all of the other companies that make a like pill construction. I hope you find some.
 
So, just curious. What is the difference between the Oramorph 15 mg "Sustained Release" and the dark blue ABG 15 pills, which are called extended release ( and I guess are generic). Is the time release binder easier to defeat with extended release oramorph? I haven't tried either yet but I assume the problem with any sustained/extended release is that it's so slow that you don't get any rush when coming on.
Also, I've never tried boofing morphine but is the point strictly the rush, or is it bioavailability? Years ago I tried snorting and IMing morphine, and never really liked it. Made me bored and sleepy, along with a lot of nausea, but obviously people enjoy it.
Thanks
 
The Mallinckrot Exalgo & Generic "plugs" are split in half one side is just like raw opium but it's high purity Hydromorphone. Like a tiny button of goo that dissolves buccal, the goo can be IV'd, shit I never tried to smoke it. But 32mg of diluadid like this a step above a "tablet".

In pharmaceutical terms, extended-release (ER) is a broad category of drug delivery, and sustained-release (SR) is a more specific type of extended release. The key difference lies in the precision and consistency of the drug's release rate. A sustained-release medication aims for a consistent, steady release over time, while extended-release can have a more variable rate of release.

What is sustained-release (SR)?
  • What is sustained-release (SR)?
    • Release profile: Sustained-release formulations are designed to release the medication at a predetermined, controlled rate to maintain a relatively constant drug concentration in the bloodstream over an extended period. This is often described as a "smoother" delivery, minimizing the peaks and troughs in drug concentration.
    • Dosing frequency: Depending on the medication and formulation, a sustained-release drug might be taken once or twice a day to maintain the constant drug level.
    • Best for: Conditions that require a very stable and consistent drug level to be effective and to prevent side effects, such as certain medications for asthma or epilepsy.
    What is extended-release (ER)?
    • Release profile: Extended-release is a general term for any formulation that releases medication over a longer duration than a conventional, immediate-release drug. This can be achieved through different mechanisms, such as sustained-release or controlled-release. The release rate for an ER drug may be gradual but not perfectly uniform.
    • Dosing frequency: Extended-release formulations often allow for once-daily dosing, as they are designed to prolong the drug's effects for up to 24 hours.
    • Best for: Conditions that require a long-acting effect where convenience and symptom relief over a longer period are the primary goals, such as managing chronic pain or hypertension.
    Comparison table
    [th]
    Feature​
    [/th][th]
    Sustained-Release (SR)​
    [/th][th]
    Extended-Release (ER)​
    [/th]​
     [td]Release rate[/td][td]Aims for a uniform, steady release rate over time.[/td][td]Releases gradually over a long period, but not always at a constant rate.[/td] [td]Duration of effect[/td][td]Typically effective for 8 to 12 hours.[/td][td]Often formulated for a much longer period, sometimes up to 24 hours.[/td] [td]Dosing frequency[/td][td]May require more than one dose per day (e.g., twice daily).[/td][td]Often designed for convenient, once-a-day dosing.[/td] [td]Primary goal[/td][td]To minimize fluctuations (peaks and troughs) in the drug's concentration in the bloodstream.[/td][td]To reduce the frequency of dosing and provide prolonged drug action.[/td]
    Is there a "better" choice?
    The choice between a sustained-release and extended-release formulation depends on the specific drug and the condition being treated. Your doctor or pharmacist will determine the most appropriate option based on:
    • The drug's properties: Some medications require a very steady blood level, while others can be effective with a more gradual release.
    • The condition: Chronic conditions may benefit from once-daily ER dosing, while others may require the precise, steady delivery of SR.
    • Patient convenience and adherence: Less frequent dosing can help patients remember to take their medication regularly.
What is extended-release (ER)?
  • Release profile: Extended-release is a general term for any formulation that releases medication over a longer duration than a conventional, immediate-release drug. This can be achieved through different mechanisms, such as sustained-release or controlled-release. The release rate for an ER drug may be gradual but not perfectly uniform.
  • Dosing frequency: Extended-release formulations often allow for once-daily dosing, as they are designed to prolong the drug's effects for up to 24 hours.
  • Best for: Conditions that require a long-acting effect where convenience and symptom relief over a longer period are the primary goals, such as managing chronic pain or hypertension.
Comparison table

Release rate[/td][td]Aims for a uniform, steady release rate over time.[/td][td]Releases gradually over a long period, but not always at a constant rate.[/td][td]Duration of effect[/td][td]Typically effective for 8 to 12 hours Often formulated for a much longer period, sometimes up to 24 hours. Dosing frequency May require more than one dose per day (e.g., twice daily).[/td][td]Often designed for convenient, once-a-day dosing. Primary goal To minimize fluctuations (peaks and troughs) in the drug's concentration in the bloodstream. To reduce the frequency of dosing and provide prolonged drug action

Is there a "better" choice?
The choice between a sustained-release and extended-release formulation depends on the specific drug and the condition being treated. Your doctor or pharmacist will determine the most appropriate option based on:
  • The drug's properties: Some medications require a very steady blood level, while others can be effective with a more gradual release.
  • The condition: Chronic conditions may benefit from once-daily ER dosing, while others may require the precise, steady delivery of SR.
  • Patient convenience and adherence: Less frequent dosing can help patients remember to take their medication regularly.
 
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