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  • N&PD Moderators: Skorpio

MPEA+selegiline

You do not have to dose selegiline that often. It destroys mao-b with the FIRST DOSE.

Selegiline BY ITSELF can make you feel very different. I don't like the sensation of selegiline. I would only take selegiline after weeks went by because I hated it so much. the PEA was always active, because the mao-b is destroyed for such a long time.

If you tried to experience "just" selegiline at 10-15mg you will be altered.

Again I stress there is NO reason to continue taking selegiline after the first or second dose of 10-15mg. NONE, unless you like the effects of it.

1 gram is very small, if you want to feel the effects of an amphetamine rush try 5grams. It wears off swiftly and the first time you will be flying for about 20 minutes.
 
toxide did you follow through with this experiment? i completely agree that caution is key with the MAO-B drug combinations but i can say that i have combined seleg with a number of stimulents and psyches with few negative experiences, as with any new combo titration is the only way to go (and start LOW!) hypothermia is a serious risk it seems although i have only experienced it with the (incredibly foolish) combination of 3mg d-amphetamine and 3mg seleg.
i think a little caution and careful titration should make the experiment fairly safe, also DL-phenalalinine+seleg never caused any kind of mania for me, just mild pleasent stimulation for the money def worth it, for any more money probably not.
 
It's really, incredibly easy to figure out which PEA is most similar to Meth.

What is Meth? It's N,a-Dimethyl-PEA.

So, subtract the a-methyl and now you have N-Methyl-PEA.

that's the one most similar.

beta-methyl-PEA is probably absolutely worthless, and ring-methylated non-alpha-PEAs are probably as well.

Does anyone suppose that para-Methoxy-PEA would be interesting? I mean, since PMA is a monoamine releaser and an MAOI, if this would do both but less so, it could be a safer, legalish replacement.
 
Sounds like a recipie for disaster to me, heh heh.
edit: Oh, I thought you meant 4-MeO-PEA + MAOI. My bad. Disregard the above ^

Would 4-MeO-phenethylamine even have any MAOI activity left? Hmm.

Another interesting one would be N-methyl-4-ethylthio-phenethylamine.

And yes meth's PEA cousin is N-methyl-phenethylamine.
 
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I sort of doubt that it would have MAOI activity, now that I think about it. AFAIK, only the a-methylated PEAs have any MAOI activity.

It might be fine with selegiline then... But no, that wasn't my original pondering.

Would Para-MeO-PEA be chewed up by MAO too fast? Does it have a chance on it's own?
 
Nah, not only the a-Me PEAs can have MAOI activity, that is why I suggested the N-methyl-4-ethylthio-phenethylamine... the 2C-T-x psychedelic PEA series has pretty strong MAOI activity, on par with PMA. The sulfur seems to stick in the mouth of the MAO pac-man.

I reckon p-MeO-PEA would be chewed up way too fast for it to have any effect at sane kind of doses. You could probably get it to work if you banged a huge quantity of it at once but this is not something we want to be suggesting :|.
 
Oh, yeah, I forgot about the 2CT's.

What substitutions allow "simple PEAs" a fighting chance?
 
I reckon p-MeO-PEA would be chewed up way too fast for it to have any effect at sane kind of doses. You could probably get it to work if you banged a huge quantity of it at once but this is not something we want to be suggesting
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I somehow think the pressor activity of the stuff would push your BP through the roof with the dose you'd need ie. don't fuck with it, it's not what the smart people would do...
 
Does anyone have any experience using Syrian Rue as a MAOI to enable use of PEA? I might be interested in very carefully trying this combo...not dipping tablespoons into a bag of powder. 8)
 
20mg of PEA (yes. the "correct" dose for this combination varies incredibly widely from person to person) + selegiline is intolerably vasoconstricting and strange for me, and it wears off in about 20 minutes. Unfortunately in me not much good for functional use/depression at all.
 
I just have to post a word of warning about selegiline. If you use a large oral dose or especially the patch form (EMSAM), MAO-A WILL be inhibited, not just MAO-B.

If you take ecstasy/MDMA in this state, you could die of serotonin syndrome and a hypertensive crisis!

Please be careful.
 
If you take ecstasy/MDMA in this state, you could die of serotonin syndrome and a hypertensive crisis!
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I'd go as far as saying if you're going to do this, book the ambulance first as it will cause one (or both) of the two symptoms


After checking, para methoxyIf you take ecstasy/MDMA in this state, you could die of serotonin syndrome and a hypertensive crisis!

After checking, looks like if you inhibit both MAO enzymes, 4-methoxy PEA will be metabolized to 4-hydroxy PEA (via catechol O-methyl transferase), which is a pressor agent & a pressor agent with MAOI is a disaster waiting to happen
 
Does anyone know of any other MAOB inhibitors that are easily available? Or the status of selegiline in Australia?
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Selegiline (sold as generics; Selgene or Eldepryl) is available via prescription in Australia. I've never found it difficult to obtain a prescription, even when it was hardly known to be used for any purpose other than as an adjunctive therapy with L-dopa. These days, more and more GP's are aware of its reputed antidepressant properties and noo-tropic claims, so getting a script is possibly even easier nowadays.

I agree with f&b comments. You certainly need to be aware of the likely metabolic products with various phenethylamines, and how efficacy may change with MAOB inhibition. Also, anecdotal evidence suggests MAOAi may occur at relatively low dosages (~10mg) in some people.
 
fastandbulbous said:
I'd go as far as saying if you're going to do this, book the ambulance first as it will cause one (or both) of the two symptoms


After checking, para methoxyIf you take ecstasy/MDMA in this state, you could die of serotonin syndrome and a hypertensive crisis!

After checking, looks like if you inhibit both MAO enzymes, 4-methoxy PEA will be metabolized to 4-hydroxy PEA (via catechol O-methyl transferase), which is a pressor agent & a pressor agent with MAOI is a disaster waiting to happen
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Most definitely. Deprenyl used in conjunction with MDMA or other stims needs to be really fucking far away from the 20mg/day cutoff point for MAOI inhibition.
 
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