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Most Novel Psychedelic/ Dissociative??

<SpaceHead>

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Jan 22, 2009
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One of the most amazing things about psychedelics is their ability to create novel states of mind. Even the most mundane things viewed through the right lens can reveal seemingly endless complexities and detail. So taking into consideration all aspects, chemistry, method of action, history/ social context and subjective effects what are the most novel ones to you? A few that are high on my list are ibogaine, PCP, DiPT, MK-801 all for different reasons. Oh yea and salvia! Things like LSD and DMT are very novel in these ways but for some reason, maybe because of their popularity or maybe because I've taken them too many times they don't seem all that novel to me anymore.
 
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I'd imagine this depends largely on the user & their individual level of familiarity with a given substance. As i don't personally have much experience with dissociatives, i find mxe to produce a pretty novel state. On the tryptamine side of things, i find 4-AcO-DET to be quite novel. Both its duration & visuals, for me, seem atypical for 4-sub tryptamines. Definitely stimulates the ol' locus coeruleus ;)

I'd be interested to hear about your experience(s) with MK-801
 
I haven't tried MK-801 I just like to read about it, not sure I'd take it, although, nah if I found it I would take it haha. Seems to be in that tiletamine type class of drugs which give you the sort of state i like to the "the dumb" where you feel detached, synthetic, industrial and either strongly neutral or dysphoric and scatterbrained. Although its probably still novel even if it sucks!

What I was thinking with the drugs that I mentioned are things like how ibogaine was traditionally used for thousands of years in religious rights until a random junkie took it out of boredom and curiosity and discovered it's profound anti-addictive effects. Also considering it's very odd chemistry and its action on so many receptors, like 5HT3 and NMDA just seems like a very odd drug to exist.

Or PCP, I forget where I read this but I remember seeing that it was first synthed in the 1920's by a german company as a pesticide, before park davis picked it up. Then it was trialed as a human anesthetic because it could anesthitize without slowing heart rate or breathing at very small doses. Imagine being a volunteer in that trial in like 1958 or something! Then rejected because of "nightmares and psychotic reactions", sent to the veterinary clinics and then to the ghetto. Seems like an odd drug to be a gangster type of drug.

And then DiPT! How does it have such a specific effect!? What is it about the diisopropyl that has so much to do with sound and pitch?? It sounds so strange! Percussive sounds are unaffected, but all tonal sounds gain extra tinny alien octaves to them, the beatles sound like tiny robot aliens! This must have some application in investigating the mechanism of human hearing.
 
I find TFMFly novel. Just look at it ffs :)

Actully I find all the dihydrodifuran analogues novel. Fly's, hemifly's, butterfly's, dragonfly's, and to think that many of these could be made as NBOMe's aswell. Like NBOMe-2C-B-Fly. I'd rather see the NBOMe-2C-C-fly though :D

540px-2C-B-FLY-SAR.png
 
True the 4 position on the tfm fly is already ridiculous but then adding wings! ive never tasted a fly...
 
Bromodragonfly is ridiculous. I don't know why anyone would want to trip that long. I prefer the other extreme of trip duration. I would have to say the most novel psych I've had is salvia. Just the fact that it works on the mu-opioid receptor should be enough. I don't think any other drug could leave me as confused as salvia.
 
Definitely salvinorin A and the salvinorin B ethoxymethyl ether off-shoots. These are not just novel chemical creations. They are novel to consciousness itself. If you play around in this area you're going to end up way left field.
 
salvia is some knarly shit.... I am sure it has a purpose, second toke thru hitter and my life was a psychedelic bb zipping around back 45 minutes, i'll never figure out diterpenes.
 
Definitely salvinorin A and the salvinorin B ethoxymethyl ether off-shoots. These are not just novel chemical creations. They are novel to consciousness itself. If you play around in this area you're going to end up way left field.

Absolutely
 
You're right about salvia, certainly the most peculiar experience one can ask a brain to be capable of! Havent done it in years though, i trip very frequently and i think it still intimidates me more than any other substance.
 
Bromodragonfly is ridiculous. I don't know why anyone would want to trip that long. I prefer the other extreme of trip duration. I would have to say the most novel psych I've had is salvia. Just the fact that it works on the mu-opioid receptor should be enough. I don't think any other drug could leave me as confused as salvia.

You mean the k-Opioid receptor? Though I agree that this does make it a novel and interesting one. While I think it falls under the dissociative class and to some extent the deliriant class of hallucinogens, this novel receptor interaction and its unique effects when compared to traditional dissociatives (e.g. NMDA-antagonists), along with its incredible potency, make it an interesting one indeed.

There's of course DiPT for its properties as being almost exclusively an auditory hallucinogen. DMT for its extraordinary depth that few psychedelics are able to match..

I also think psychedelics that exert empathogenic effects like aMT are quite novel as they combine the effects of two of the most popular classes of recreational drug and offer a new experience entirely to either alone.
 
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