rangrz
Bluelighter
So, I got me some Modafinil My brand name is ModAlert, made by the reputable Sun Phama in India...USA trade name for reference purposes is Provigil.
I find it is generally like such, regardless of dosage
0000- eat it.
0015 Begin to notice feeling of itchiness. Probably because at least part of its path of action is release of histamine in certian areas of the brain. (and obviously systemic since it makes me itchy and gives me a stuffy nose)
0030 I feel very very awake and alert and sharp. Some euphoria, but nothing like most recreational stims.
It seems to carry for 6-7 hours, at which point it wears off quite gently.
I found personally that increasing dosage increases the side effect profile far more then it increases the desirable effects of the drug.
I also found this stim makes me VERY harsh. There is no empathy, kindness, love, pity, or anything...I feel very very alert, smart, awake, powerful, but just dead cold/mean and agressive. More then any other stim, this one makes me a MEAN mother fucker.
It feels to me like it targets Dopamine and Beta Adenergenic receptors, and perhaps Norepherine. I feel nothing that is typical of serotonin type action...not physically (no neasua or increased bowel movement...not much supression of appetite) or mentally (no empathy/kindness/love/ect) Which really isnt bad at all. Its actaully pretty awesome...just an emotionless cyborg bad ass...no, not emotionless...that would be anti-physotics...just RAAAAAAAAAAAAAAAAAAAAAAAAAAGE! or self satisfaction as my only emotions...the raaaage much like this happy looking fellow.
On most other stims (coke, meth, ritalin, ect) I feel still affectionate and loving towards people that I care about, and am not just "here to kick ass and chew bubble gum, and I'm all out of bubble gum"
My ideas about its receptor activity are endorsed by drug bank.
"The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors."
The histamine release I read of erowid and wiki...less reputable sources, but it feels right. (the itchiness and stuffy nose...)
All in all....I actaully very much like this stuff... it sure does wake the hell up out of me when I need to get my ass in gear, and allows me to go about my day without worrying too much about anyone else, or missing my GF, wondering what my friends are up to, ect. Just pure motivation to get done things I need to do for my benefit. (work, school, ect)
I know this is not the best trip report ever, but this is more or less what I got out of modafinil, alertness and "soft" emotions blunted while "hard" ones are exaberated. aka...ego growth to the MAX
I find it is generally like such, regardless of dosage
0000- eat it.
0015 Begin to notice feeling of itchiness. Probably because at least part of its path of action is release of histamine in certian areas of the brain. (and obviously systemic since it makes me itchy and gives me a stuffy nose)
0030 I feel very very awake and alert and sharp. Some euphoria, but nothing like most recreational stims.
It seems to carry for 6-7 hours, at which point it wears off quite gently.
I found personally that increasing dosage increases the side effect profile far more then it increases the desirable effects of the drug.
I also found this stim makes me VERY harsh. There is no empathy, kindness, love, pity, or anything...I feel very very alert, smart, awake, powerful, but just dead cold/mean and agressive. More then any other stim, this one makes me a MEAN mother fucker.
It feels to me like it targets Dopamine and Beta Adenergenic receptors, and perhaps Norepherine. I feel nothing that is typical of serotonin type action...not physically (no neasua or increased bowel movement...not much supression of appetite) or mentally (no empathy/kindness/love/ect) Which really isnt bad at all. Its actaully pretty awesome...just an emotionless cyborg bad ass...no, not emotionless...that would be anti-physotics...just RAAAAAAAAAAAAAAAAAAAAAAAAAAGE! or self satisfaction as my only emotions...the raaaage much like this happy looking fellow.
On most other stims (coke, meth, ritalin, ect) I feel still affectionate and loving towards people that I care about, and am not just "here to kick ass and chew bubble gum, and I'm all out of bubble gum"
My ideas about its receptor activity are endorsed by drug bank.
"The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors."
The histamine release I read of erowid and wiki...less reputable sources, but it feels right. (the itchiness and stuffy nose...)
All in all....I actaully very much like this stuff... it sure does wake the hell up out of me when I need to get my ass in gear, and allows me to go about my day without worrying too much about anyone else, or missing my GF, wondering what my friends are up to, ect. Just pure motivation to get done things I need to do for my benefit. (work, school, ect)
I know this is not the best trip report ever, but this is more or less what I got out of modafinil, alertness and "soft" emotions blunted while "hard" ones are exaberated. aka...ego growth to the MAX
