Mixing Ritalin and Amphetamines

[razorcuts]

In theory would mixing both drugs lead to syngerism or would
it be counterproductive?

Ritalin is a DA/NE reputake inhibtor.
Amphetamine releases DA/NE.

To me it sounds as if mixing both could make each other stronger.

I also wonder how unhealthy such a combo would be in terms of neurotoxicity.

 

[aced126]

Low doses of both would probably potentiate each other (2 respective sub-therapeutic doses might suffice for a therapeutic dose in one of the them) but as soon as you take say amphetamine in high doses such that DAT is saturated, then all that the ritalin will do is block DAT from pumping DA from the neuron into the synaptic cleft, thus dampening the effects from amphetamine, but also preventing neurotoxicity.

 

[razorcuts]

Hello. I thought that reuptake inhibition simply means that DA/NE are forced to stay in the cleft. If this also prevents DA for being released then wouldn't this be counterproductive? Then why is it not called release inhibition?

 

[Cotcha Yankinov]

Some drugs known as releasing agents work by reversing the transporter, so inhibiting the transporter will stop the mechanism of amphetamines to a degree, like aced said I think you will find a sweet spot and also a point of diminishing returns. But neurotoxicity would be the main concern. I would take some high dose anti oxidants.

 

[Nagelfar]

Hello. I thought that reuptake inhibition simply means that DA/NE are forced to stay in the cleft. If this also prevents DA for being released then wouldn't this be counterproductive? Then why is it not called release inhibition?

In some sense, the "atypical" reuptake inhibitors (benztropines, GBR series compounds, mazindol) actually do inhibit release too, and are reasoned thereby (coinciding with observation) considered to be not habitually reinforcing/euphoric, and actually some studies have shown them to be, in-fact, dysphoric. I tend to think the "atypical" inhibitors are recognized as an interference to DAT, and the brain accounts for that by somehow recognizing it. As for whatever reason Singh's paper on typical binding site antagonists doesn't classify them as such, whether that's because they're method of also blocking release is different or just because he wanted, specifically, one that did not interfere with uptake of DA whatsoever to be considered a "functioning" antagonist, I know not.

 

[serotonin2A]

I tend to think the "atypical" inhibitors are recognized as an interference to DAT, and the brain accounts for that by somehow recognizing it.

Increasing synaptic dopamine concentrations would activate autoreceptors, leading to a reduction in evoked dopamine release.

 

[razorcuts]

That's interesting stuff. I wonder how many psychiatrist know about this and could answer if ritalin and amphetamine would enhance each other or not. But what kind of antioxidants are useful in order to prevent neurotoxicity?

 

[Ligaturd]

I have personally found dextroamphetamine and methylphenidate as well as a seperate cocaine and methamphetamine combination to do exactly that. Euphoria was not present at all that was noticed was an insane amount of peripheral stimulation, vasoconatriction etc. I felt quite stimulated but it was not enjoyable whatsoever. I have had quite a few arguments with a friend over it so I decided to try it myself but he still doesn't believe me.