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  • BDD Moderators: Keif’ Richards

Mixing drugs, common sense or not?

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Bluelighter
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Nov 7, 2010
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I've been arguing with a friend this morning a bit on whether common sense overrules possibly differing reality in this specific situation, or others similar to it.

It started yesterday with someone telling me if you were being forced to use heroin that taking vicodin (hydrocodone of course) before would "block the heroin and keep you relatively sober". I immediately said that's total bullshit and I can prove it. So about 10 seconds of Google proved that, then just for fun I asked my friend who knows quite a bit about many drugs what he thought, and he said that's not necessarily true and he had no idea if heroin+vicodin would work like that or just increase the effect.

Now I was using drug knowledge and common sense when I figured opiate + opiate = even more high. Is there any situation that any of you can think of where combining 2 drugs of the same class would cancel the effect rather than increase it?

I can't think of a single one, and if I had to guess I'd say if there is one, the number of combinations in which the effect is just increased (probably dangerously) is far far higher than the number of combinations where drugs of the same class negate effects in a safe way.
 
It can be fun and it can be fatal.
Heath Ledger took it too far. But then again, anyone who can play both the Joker and a gay cowboy obviously has a pretty ambitious outlook on life in general.
i like to drugs one at a time tho, if u do them together u waste them because you could save one for your next free day
unless it's cannabis which i like to mix with psychedelics
 
Well, I don't know if this counts, but methadone blocks the effects of other opiates/opioids at high enough doses. Of course, methadone is not exactly in the same class as, say, oxycodone.

"Blocks" might not be the correct term. Methadone floods certain opioid receptors (forgot which ones, too lazy to google...mu???), which in turn doesn't allow other opiates/opioids access to the receptors. So, you don't feel higher. It is possible to "jump" a methadone dose if you take enough of something else, but the effects are not the same...very dull.

So, again, I'm not sure if this counts, but it's an example.
 
Mixing drugs to block heroin is the silliest thing I've ever heard. Each drug affects your system differently, and you can believe that mixing some can be lethal.

Benzos , with heroin and other meds , can be deadly. (lost friends tothis combo)

Methadone , at high levels can block, so can Suboxone. Hydrocodone and oxycodone isn't going to block, only increase that high.
 
Combining two strong opioids won't completely cancel each other out. Two drugs of the same class can however compete for affinity of the receptor. Taking a high affinity opioid such as heroin alongside a low affinity opioid like codeine will result in the heroin overpowering and essentially stripping the codeine from mu.

More obvious, extreme examples would be methadone and buprenorphine combos. There are also many people who complain that mixing kratom and tramadol with certain opioids results in a 1+1=1.5 effect... some reporting severely dulled experiences.

I've compiled a few complaints of this phenomena, fwiw this is something that I've also experienced first hand a couple times. Kratom is a strange opioid with many components though, and some feel kratom/opioid combos provide synergy while others find this semi-blocking effect. Not sure what to make of it.

NSFW:

When it comes to my pet fish, he did not like the combination of the 2. He took 20 mg's of oxycodone about 4 hours after taking 5 g's of kratom. It did not make him feel bad, it just seemed like a waste of the percocets since the kratom seemed to "cancel out" many of the effects of the oxycodone. So, in my opinion, from a health perspective, I'd say it won't kill you, but it would be a waste of the great euphoria only acheivable from oxycodone, without kratom.
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Quote taken from this thread ( http://www.drugs-forum.com/forum/showthread.php?t=9715 ).

I had a bad experience with codeine and kratom they blocked each other out and gave me a toxic like feeling in my head.
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^^interesting you'd say that, since I was wondering. I take tramadol daily and have had mixed effects from kratom. When I would take tramadol the same day as heroin I would notice some seriously diminished effects from the h so i was wondering if this was why sometimes i felt the kratom and sometimes i didn't. But if it works for you to have both it just may be my funky metabolism
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I concur with the notion Kratom can block or diminish the effects of poppy tea or hydro . . . and vice versa. If that makes sense. I've taken my usual dose of 4 grams, extract/resin Kratom and then followed up with 2 cups of poopy tea and felt very light effects. It just wasn't worth it, as I felt more tired and a bit ill combining the two. Just my experience though . . . others may expereince better results
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These quotes were taken from this thread ( http://forum.opiophile.org/showthread.php?990-Kratom-with-opiates ).
 
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I say most drugs should not mix, unless you need benzodiazepines or alcohol.. Nothing is more comparable to opiates alone IMO
 
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Is how I get mine
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