• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Mixing codeine and kratom

AngelOfDeath415

Bluelighter
Joined
Sep 29, 2024
Messages
44
Would taking kratom after codeine enhance the effects? From my google results it seems they're doing exactly that in SE Asia and there is some studies claiming there's enhanced effects.
 
Yes, they will potentiate each other. But if taken together frequently kratom will cause cross tolerance eventually.

Kratom also inhibits CYP3A4, but probably to a lesser extent than grapefruit juice.
 
Yes, they will potentiate each other. But if taken together frequently kratom will cause cross tolerance eventually.

Kratom also inhibits CYP3A4, but probably to a lesser extent than grapefruit juice.
I am just taking some M3s for a week until I can refill my oxy script. But your comments about kratom potentiate codeine perked my ears. I'm just looking for a little bump up in the codeine cause I'm only taking 4 m3 pills daily, sooo my question is would 3-7 kratom 0.6 mg each be enough to get me a little potentiate from such a small codeine amount daily??
 
Would taking kratom after codeine enhance the effects? From my google results it seems they're doing exactly that in SE Asia and there is some studies claiming there's enhanced effects.
I would recommend not to, at very least not often. The reason bupe blocks the effects of full agonists is because it's a partial agonist, so mostly what you're feeling is gonna be the kratom. It may work well the first time you do it, but it's gonna lose that umph very fast once the kratom is in your system. Sure, there will be more effects than taking either alone, but this isn't potentiation. It's additive effects. And it's unlikely that the effects are better than taking more of one or the other alone.
 
I would recommend not to, at very least not often. The reason bupe blocks the effects of full agonists is because it's a partial agonist, so mostly what you're feeling is gonna be the kratom. It may work well the first time you do it, but it's gonna lose that umph very fast once the kratom is in your system. Sure, there will be more effects than taking either alone, but this isn't potentiation. It's additive effects. And it's unlikely that the effects are better than taking more of one or the other alone.
Ok. So you not saying it not gonna affect our CYP3A4 ? I like your advice ....JS
 
Ok. So you not saying it not gonna affect our CYP3A4 ? I like your advice ....JS
No, I am not saying anything about it's effects on enzymes and metabolism of other drugs, but I am saying that it could fuck up the feelings of stronger opioids by binding to the same receptors but agonizing more weakly.
 
No, I am not saying anything about it's effects on enzymes and metabolism of other drugs, but I am saying that it could fuck up the feelings of stronger opioids by binding to the same receptors but agonizing more weakly.
Would this include codeine? I understand opioids and the difference between say oxy and M3s. The amount of agnostic effect is affected pretty hard on the weaker codeine. Thanks for elaborating.JS
 
in my experience taking Kratom a few hours after dosing codeine works fine and potentiates the high. when I did kratom first and then took codeine it just made me fall asleep for most of the day
 
in my experience taking Kratom a few hours after dosing codeine works fine and potentiates the high. when I did kratom first and then took codeine it just made me fall asleep for most of the day
Yeah, IME it seems to me that taking kratom before opis like codeine or DHC effectively blocks the opiate receptors and stops the opis working.

I believe it takes several days for the blocking effect to clear, as several times I have experienced no effects from DHC on an empty stomach several days after having last consumed kratom. I've still not worked out exactly how long it takes my metabolism or brain chemistry to clear the kratom, but I do know that it is longer than 5 days! This is just my own experience, I've had other people agree with me, but mention varying time frames of 1-2 days upwards when I've asked the question about kratom and opiate blocking in various places.

I think if you take the opis before the kratom that can be alltogether different. I've not tried that myself but I have read some anecdotal reports from others of 'topping up' a dose of heroin with some great quality Red Borneo for example, and experiencing a heightening of the effects of both as a result.
 
Top