AngelOfDeath415
Bluelighter
- Joined
- Sep 29, 2024
- Messages
- 44
Would taking kratom after codeine enhance the effects? From my google results it seems they're doing exactly that in SE Asia and there is some studies claiming there's enhanced effects.
I am just taking some M3s for a week until I can refill my oxy script. But your comments about kratom potentiate codeine perked my ears. I'm just looking for a little bump up in the codeine cause I'm only taking 4 m3 pills daily, sooo my question is would 3-7 kratom 0.6 mg each be enough to get me a little potentiate from such a small codeine amount daily??Yes, they will potentiate each other. But if taken together frequently kratom will cause cross tolerance eventually.
Kratom also inhibits CYP3A4, but probably to a lesser extent than grapefruit juice.
I would recommend not to, at very least not often. The reason bupe blocks the effects of full agonists is because it's a partial agonist, so mostly what you're feeling is gonna be the kratom. It may work well the first time you do it, but it's gonna lose that umph very fast once the kratom is in your system. Sure, there will be more effects than taking either alone, but this isn't potentiation. It's additive effects. And it's unlikely that the effects are better than taking more of one or the other alone.Would taking kratom after codeine enhance the effects? From my google results it seems they're doing exactly that in SE Asia and there is some studies claiming there's enhanced effects.
Ok. So you not saying it not gonna affect our CYP3A4 ? I like your advice ....JSI would recommend not to, at very least not often. The reason bupe blocks the effects of full agonists is because it's a partial agonist, so mostly what you're feeling is gonna be the kratom. It may work well the first time you do it, but it's gonna lose that umph very fast once the kratom is in your system. Sure, there will be more effects than taking either alone, but this isn't potentiation. It's additive effects. And it's unlikely that the effects are better than taking more of one or the other alone.
No, I am not saying anything about it's effects on enzymes and metabolism of other drugs, but I am saying that it could fuck up the feelings of stronger opioids by binding to the same receptors but agonizing more weakly.Ok. So you not saying it not gonna affect our CYP3A4 ? I like your advice ....JS
Would this include codeine? I understand opioids and the difference between say oxy and M3s. The amount of agnostic effect is affected pretty hard on the weaker codeine. Thanks for elaborating.JSNo, I am not saying anything about it's effects on enzymes and metabolism of other drugs, but I am saying that it could fuck up the feelings of stronger opioids by binding to the same receptors but agonizing more weakly.
Yeah, IME it seems to me that taking kratom before opis like codeine or DHC effectively blocks the opiate receptors and stops the opis working.in my experience taking Kratom a few hours after dosing codeine works fine and potentiates the high. when I did kratom first and then took codeine it just made me fall asleep for most of the day
Thanx!in my experience taking Kratom a few hours after dosing codeine works fine and potentiates the high. when I did kratom first and then took codeine it just made me fall asleep for most of the day