maximumstrength2
Bluelighter
- Joined
- Nov 24, 2009
- Messages
- 68
I was just wondering if it was safe to mix bile with stadol or Nubian and if there is any potential for catching a buzz. Any thoughts or experiences would be appreciated
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BDD Moderators: Keif’ Richards
mixing bupe with other partial agonists
- Thread starter maximumstrength2
- Start date
Toz
Bluelighter
Bleh, bupe mixes with nothing in my oppinion except fentanyl (and there it doesn't mix either but at least fentanyl overrides the stupid bupe), I have no idea what those opiates are but other partial agonstists, I think they would just kill the effect of each other.
Bupe will just kill effect of everything, even if you don't get precipitated withdrawals it overrides the effects and places itself there instead. And I would never want that, any other opiate is more fun than bupe. Bupe just sucks. I'll get high on tramadol or codeine any day rather than buprenorphine.
Bupe will just kill effect of everything, even if you don't get precipitated withdrawals it overrides the effects and places itself there instead. And I would never want that, any other opiate is more fun than bupe. Bupe just sucks. I'll get high on tramadol or codeine any day rather than buprenorphine.
Swimmingdancer
Bluelight Crew
These are good questions. To give a proper answer I'd need to go into detail about the science about how these drugs work, but that would take a very long time. Basically there is no point to it, bupe will block them, aside from some unwanted side effects. I don't think it would be unsafe (at least no more unsafe than taking a higher dose of one of these drugs), just pointless. It's possible that you might get a slight additive effect from the Butorphanol, but probably not and it would be wiser just to stick to bupe by itself.
Why you would want to take them together I don't know, it would be easier and wiser to just take one of them. With partial agonists like bupe most people find lower doses to be more "recreational" than higher doses anyway, if you are using them for that purpose. If you are on bupe maintenance and are hoping that one of these other drugs would break through bupe's blockade effect I highly doubt that, at the very best it would be like taking more bupe.
Nubain is apparently a full mu-opioid receptor antagonist and a full k-opioid receptor agonist [Gustein et al 2001], so you wouldn't want to take that one recreationally unless you like depression/dysphoria, dissociative and deliriant effects, without the regular mu-opioid effects associated with drugs like morphine.
Why you would want to take them together I don't know, it would be easier and wiser to just take one of them. With partial agonists like bupe most people find lower doses to be more "recreational" than higher doses anyway, if you are using them for that purpose. If you are on bupe maintenance and are hoping that one of these other drugs would break through bupe's blockade effect I highly doubt that, at the very best it would be like taking more bupe.
Nubain is apparently a full mu-opioid receptor antagonist and a full k-opioid receptor agonist [Gustein et al 2001], so you wouldn't want to take that one recreationally unless you like depression/dysphoria, dissociative and deliriant effects, without the regular mu-opioid effects associated with drugs like morphine.
XThexXTank
Bluelighter
There are so many threads on this topic. Its gotta long half life so ya gotta wait at least 24 even up to 48 hrs before takin an opiate n feelin its effects.
Swimmingdancer
Bluelight Crew
Do you mean when taking them not at the same time? I don't see how antagonists taken with agonists could potentiate them.
The OP is asking about other partial agonist/antagonists though, not regular full-agonist opioids.
ultra low dose antagonists super sensitize opioid receptors when coadministered with a full agonist. bupe supposedly activates a small number of receptors with minimal activity and synergizes when used with full agonists (talking microgram doses for both bupe and antagonists).
as for the original question: check the binding affinities for the different receptors. bupe binds pretty tightly thus preventing other opioids from working (nothing to do with it being a full/partial agonist at different receptors). if you could find something with a higher binding affinity then it will get you higher. thats about it.
as for the original question: check the binding affinities for the different receptors. bupe binds pretty tightly thus preventing other opioids from working (nothing to do with it being a full/partial agonist at different receptors). if you could find something with a higher binding affinity then it will get you higher. thats about it.
Swimmingdancer
Bluelight Crew
That's so crazy, how does this work? Is it a theory or something you have tried (or know someone who has tried it)?
If something had a higher binding affinity than bupe (which from what I read about the drugs the OP asked about these drugs don't, hence my answer) wouldn't it just cancel out the bupe though?
Pill2Chill
Bluelight Crew
Pentazocine caused a strong nod in me that was not very pleasant on its own, but combined with tramadol it was awesome. Maybe bupe+pentazocine has the same potential?
uldn has been tested by quite a few junkies (there's a recipe online for making your own naltrexone water to cook up your heroin with). doctors and researchers are thoroughly intrigued as ultra low dose naltrexone seems to prevent tolerance from building too. there's a new pill formulation that consists of oxycodone and naltrexone that's still in trials I believe and its working wonders.
as for the binding affinity, yes and no. depends how much of the drug the person takes. it will travel the path of least resistance (open receptor) most of the time with some knocking off other opioids at other receptors. so it could synergize, or be competitive, or a combination of both.