mirtazapine interaction with alpha-methyltryptamine

[pofacedhoe]

if you combine mirtazapine with alpha methyl tryptamine, what would be the possible negative interactions

i am aware aMT is a mild maoi, i was more focusing on the powerful monoamine releasing properties combined with the mirtazapine as i want to introduce it to a friend who is on mirtazapine if its safe to do so. i remember when taking citalopram that mdma had very little effect, and was wondering if anyone has any personal experience with this combo or any better understanding than that which wikepedia has given me (not much really)

thank you

 

[MeDieViL]

Mirtazepine can theoretically blunt monoamine release induced by AMT (since 5HT2A plays a major role in that, it doesnt block the serotonine transporter like SSRI's) and block serotogenic effects mediated by the serotonine agonism since it acts as a inverse agonist at several serotonine receptors, id look for experiences regarding MDMA and mirtazepine as that will most likely be simular.

 

[Slapdragonx]

Mirtazepine is used to treat serotonin syndrome, so it is safe.

 

[MeDieViL]

Oh yeah i forgot to mention, it will completely abolish all psychedelic effects as its a inverse agonist at the 5HT2A receptor (basicly blocks the receptor that mediates the psychedelic effects).

 

[Isidor]

Old thread, but would like to add that I felt very little psychedelic effect on aMT even at very high doses (like 150mg) while on Mirtazapin... I was uneducated at the time (but now I know better). So MeDieViL is correct in that it abolishes the psychedelic (though not completely; I did get some small effects, like my sweater looking like a water surface with small rippling waves, but bear in mind this was at 150mg which is about twice the strongest dose on Erowid).

 

[SNR]

Mirtazepine is used to treat serotonin syndrome, so it is safe.

Dangerous assumption right here. Mirtazapine has indirect agonistic effects on the 5-HT1A receptor, which is associated with serotonin syndrome.

I don't know much about AMT, but I do know that it is a non-selective agonist at serotonin receptors. Not sure how much this has to do with subjective effects; but remember that mirtazapine blocks most of the serotonin receptors with the exception of the 5-HT1A (see above) and therefor might leave you with rather weak if not absent psychedelic/subjective effects.

~snr

 

[Amu]

It's agonism of 5-HT(1A) is weak at best, no where near enough to cause serotonin syndrome (though very rare cases have happened), or even compound the problem, you'd really shit a ton of AMT + Mirtazapine to overdose.