Minimizing 2Cx burn(insuffilation)

[karona]

Normally i won't consider this. Except when am getting towards peak time and may snort 5mg or so to increase the experience.

Would like to know if anyone has found something to make the burn/sting more minimal. Sometimes i use a frozen beer mug(and put it to the nose/nostril. Helps but some 2c's are less forgiving. 2CE seems to go down smooth due to it's fluffy nature but others burn more than others. Even if there is something can stick up the nose to ease it. Imagine milk won't help much.
Any ideas. Am wanting to do a 15-20line right now but am getting put off by the burn of 2ci.

 

[nearjat]

I bet you could procure some procaine and mix it in with the PEA you wish to consume

 

[karona]

Actually never thought of that. Will have to try that in the near future sometime.

Might have to grow some more balls and just do it atm though.

(i have never tried procaine) So what is the different effects of the caine type anethstetics around/better ones to get) ?

 

[nopipesdfw]

Nitrous, lol. It really does work pretty well if you've got the money to spare yourself most of the pain for a little. (But then you aren't going to fry from them like you would just a little bit later!)

 

[karona]

My shit is burning pretty good right now. Beer isn't helping @ all!

Didn't really hurt till bout t-minus 10min in..grrr
Totally has the beer that i DID drink Locked up in my stomache

 

[karona]

Mixing mephedrone and 2cx is great. Really takes away the 2c burn. 2c +4aco+meph = a great combo for snorting. W or w/ out the 4aco

 

[invert]

Yeah, I have to say I've found some mephedrone, or even methylone, smoothes the way for intranasal assault very well. Harmreductionwise, though, surely it's better to put up with the pain (or use another ROA entirely) than to combine with stimulants? Each to their own I guess, but I find, for example, 2C-B and 4-FA perfectly acceptable intranasally even without protection. I don't know if it hurts me less than most, or I care less about nasal pain than most; I don't know, I've just repeatedly been surprised by how snortable (albeit with brief bearable pain) things are that many people say are outrageously painful (with comparisons made to unbelievable excruciating injuries).

ETA: Is it necessarily the case that if a chemical activates pain receptors in the nasal cavities etc, thus producing more pain, that means it must be causing more damage? Or are the two things (pain and actual damage) dissociable?

 

[nearjat]

I'm assuming that the substance being a microcrystalline powder makes it feel like snorting glass because it really sort of is like snorting glass haha.

In some cases pain and actual damage are dissociable, like with spicy food. This probably isn't one of them.

 

[invert]

In some cases pain and actual damage are dissociable, like with spicy food. This probably isn't one of them.

No? I suppose a relevant question would be whether the sort of receptors that a psychedelic might activate (e.g. serotonin receptors) are involved in pain. *googles serotonin + nociception*

Okay, here's something: http://www.jneurosci.org/cgi/content/short/22/3/1010 Just glanced at the abstract, but it appears there's a serotonin subtype 5-HT3 receptor involved in nociception. Now, I don't know if any 2C-x is active at that subtype, but it looks like it's not inconceivable that a serotonergic chemical could produce pain perception without damage. A sort of psychedelia of pain, as it were.

 

[nearjat]

Huh you could be on to something

I just don't think that the compound even metabolizes at that point. Maybe I'm misinformed, but the chemical wouldn't be able to activate some receptor in the sinuses like that would it? Since there would be no serotonin receptor there.

 

[invert]

Huh you could be on to something

I just don't think that the compound even metabolizes at that point. Maybe I'm misinformed, but the chemical wouldn't be able to activate some receptor in the sinuses like that would it? Since there would be no serotonin receptor there.

Well, according to http://informahealthcare.com/doi/abs/10.1080/000164801300102932 serotonin receptors (albeit not specifically the same ones from that other paper; but this is just a very cursory googling of the literature, I'm sure there's more out there) can be found in the nasal mucus membranes.

I'm by no means convinced that the pain is 'illusory' or psychedelic, and I've no idea how quickly it could act on the serotonin receptor, and whether it would be quick enough to explain the speed of onset of the pain. I just think it's a possibility, just as I wonder whether the motor jitteriness experienced on some psychedelics (I've had it on DiPT and 2C-C, and I believe 4-HO-DiPT is known for it) can be construed as a psychedelia of the motor cortex.

 

[karona]

Mephedrone burns but covers up the 2cx and mixes quite well. Tried it with something else just actually not sure what it was. Felt kinda good but mixed some 2c w/ and didn't hardly even feel it!
By itself it really hurts. 2ci u won't even feel for a few seconds sometimes then it's like mace in your nose. Others immediate.

 

[nopipesdfw]

Being passed out on nitrous as often as possible for fifteen minutes has done the job for me when I have the money and crave.

Mixing ~10mg bumps of 2C-I into lines of K has made the burn something I almost have not picked up on. (Being on K beforehand might have helped.)

Drugs to cover up the side effects of other drugs is generally not the safest, but it seems effective for 2C-X snorting. However, dripping water through your nose is the best non-psychoactive trick I have noticed a difference with.

 

[sackynut]

a few things I do that usually help a little bit, although occasionally not at all.
1. soak a qtip in isoproyl alcohol and swap out that nasal passage. it completely cleans out that bad boy, and while you would THINK it would make the burn WORSE, it seems to help with absorption AND lessen the burn. it feels more like a "hot" feel than a normal nasal burn. this has no effect on that drip though.
2. mix it in with something. sometimes i use ondansetron which helps with the burn and also helps with the nausea (but i assume the binders and fillers probably dont help with absorption any). or mix it with some mdma, adderall etc etc.
3. smoking bowls usually helps take my mind off the nasal burn, and in some weird way helps with the drip burn i the back of the throat.

g'luck

 

[TNT Explosion]

Mixing mephedrone and 2cx is great. Really takes away the 2c burn. 2c +4aco+meph = a great combo for snorting. W or w/ out the 4aco

Mephedrone burns but covers up the 2cx and mixes quite well. Tried it with something else just actually not sure what it was. Felt kinda good but mixed some 2c w/ and didn't hardly even feel it!
By itself it really hurts. 2ci u won't even feel for a few seconds sometimes then it's like mace in your nose. Others immediate.

Would mixing a non-active/threshold dose of mephedrone (like 10-20mg) with the 2c's work for covering up the burn?