Mg2+ (magnesium) transport mechanism

[i are spectre]

all my biology classes and i was never taught about the significance of Mg2+ and ATP (among many other bio-compounds):

what i can't find is information regarding the transport of Mg2+ across cell membranes... anyone have a clue?

all i have come up with are a few medical document previews that want some money to view the whole thing...

[yes i realize that is not ATP above...]

 

[sekio]

all i have come up with are a few medical document previews that want some money to view the whole thing...

Link to the abstracts and someone will post the full-texts

I was under the impression that charged cations are transported by ion channels.

 

[Deleted member 170540]

There's little info about magnesium transport because no one really has a clue...

From wikipedia:

http://en.wikipedia.org/wiki/Magnesium_in_biology

Magnesium transport

The chemical and biochemical properties of Mg2+ present the cellular system with a significant challenge when transporting the ion across biological membranes. The dogma of ion transport states that the transporter recognises the ion then progressively removes the water of hydration, removing most or all of the water at a selective pore before releasing the ion on the far side of the membrane. Due to the properties of Mg2+, large volume change from hydrated to bare ion, high energy of hydration and very low rate of ligand exchange in the inner coordination sphere, these steps are probably more difficult than for most other ions. To date, only the ZntA protein of Paramecium has been shown to be a Mg2+ channel. The mechanisms of Mg2+ transport by the remaining proteins are beginning to be uncovered with the first three dimensional structure of a Mg2+ transport complex being solved in 2004.

See also http://en.wikipedia.org/wiki/Magnesium_transport

 

[Epsilon Alpha]

Wouldn't mind doing some research on this if epigenetics and medicine don't work out...

 

[atrollappears]

Yep, Mg2+ is too electronegative to be transported like a normal ion because it 'sticks' to all the water molecules around it. That's why it blocks NMDA receptors even though it's smaller than Ca2+.

 

[Josair]

Link to the abstracts and someone will post the full-texts

I was under the impression that charged cations are transported by ion channels.

Or use google scholar - almost always it will find multiple 'versions' of a paper - some are links to sciencedirect, publishers' sites, etc; other are link to public libraries catalogs, but sometimes you will also find pdf, often hosted by some university