metoclopramide and MAOI

[Pano]

Hi Everybody

I saw, on the metoclopramide hydroclorid notice, that it's better not to use it in combination with a MAOI ...

Swim is actually in treatment with metoclopramide (2x10mg/day, 20 min. before meal) but would like to participate to an Ayahuasca session; so I'd like to know if anyone here has already taken metoclopramide before (or after) an Ayahuasca session ?
It's useful to mention that Swim is experienced with Ayahuasca (> 50 sessions) and is strictly under MAOI diet (no drugs, no alcohol, no fermented food, and so on ...)

Thanks for you answers

 

[MurphyClox]

1. Welcome at Bluelight.
2. Please no SWIMming, it's pointless.
3. I have never taken this compound (so, no personal experience), but I don't see any serious problems at the moment. The effects of metoclopramide will be felt stronger, but that won't do you much harm in the short term...

Peace! Murphy

 

[Aeon Psyche]

I took way to much of this stuff once (70 Mg ?) and it was truly not enjoyable. I also mixed it with alcohol and felt weird the whole time. I recommend against it. And that goes for ayahuasca too. One of the worst drugs I've ever done. How the fuck you manage to poison yourself with it 50 times is beyond rational thought :s

 

[MurphyClox]

I think if he can stand the effects of ayahuasca, he will deal with this experience, too. 70 mg meto is far more than the dose decribed by the thread opener (2x10 mg a day!), so that's no good comparison.

Pano, if you want to stay on the safe side, then take half the dose metoclopramide (just the single dose before the ayahuasca) and be sure to have several hours between the trip and the next metoclopramide.

Take for example this:
"Pharmacokinetics of tetrahydronorharmane (tetrahydro-β-carboline) in rat"

The distribution, metabolism and elimination into the urine of (14C)-tetrahydronorharmane (THN) as well as of (14C)-6-hydroxy-tetrahydronorharmane (6-OH-THN) are investigated in female and male rats. Following intravenous injection of (14C)-THN radioactivity was detected in all organs examined, namely blood, brain, lung, adrenal gland, small intestine, fat tissue, kidney and liver.
In the brain the elimination half life of THN was calculated to be 1.8 h, the elimination half life of the radioactivity in the blood 6.24 h, and the accumulation half life in the urine 9.24 h. The elimination of 6-OH-THN into the urine is faster than that of THN.
At least four metabolites of (14C)-THN were found in the urine of female rats. Two different metabolic pathways are discussed, firstly, hydroxylation followed by conjugation with glucuronic and sulfuric acids and secondly, dehydrogenation, followed by oxygenation. In female rats only traces of the conjugated metabolites are hydrolysed by arylsulfatase, whereas in male rats approximately 2/5 are cleaved by this enzyme.
Pretreatment of male rats with 3-methylcholanthrene induced conjugation, whereas phenobarbital had no obvious effect on the pattern of metabolites. SKF 525 A and CFT 1201 both prevented almost completely the formation of conjugates from THN.

Don't know about halflife of the other harmala-alkaloids but I think when dosing the meto just every 12 hours, we don't have a serious problem here.

Question: Do you have any side-effects from the meto or does it finely do what it's supposed to do?

Peace! Murphy

 

[Pano]

Thanks for your answer MurphyClox

No side-effets, the meto does only what it's supposed to do (gastric problems)



@ Aeon Psyche : Ayahuasca isn't a drug, it'a a medecine ^^

 

[MurphyClox]

The 'drug vs. medicine' issue is more of the philosophical kind...

I asked for side-effects, because if you would feel any serious side-effects already at therapeutic doses, I would not recommend the ayahuasca-experiment.
But as long as there are none, go ahead...

Murphy

 

[Aeon Psyche]

Thanks for your answer MurphyClox

No side-effets, the meto does only what it's supposed to do (gastric problems)



@ Aeon Psyche : Ayahuasca isn't a drug, it'a a medecine ^^

A lot of medicines are drugs. Most of them. Ayahuasca is a drug. For the sake of friendship let's just call them psychoactives.

Do you believe alcohol is just a drink too? Wake up, man.