Stimulants Methylphenidate + SSRI recreational value

[high_yields]

Hi,

Methylphenidate is an ADHD medication that works through inhibition of dopamine and norepinephrine reuptake transporters (DRI and NRI respectively). SSRI's like Sertraline are antidepressant medications that work by inhibition of serotonin reuptake transporter (SERT). Inhibition of these transporters increase according neurotransmitter levels in the synapses. Methylphenidate can be used off-label at higher doses recreationally for it's stimulating and euphoric effects. Cocaine is a well known recreational stimulant that exerts its effect's through triple inhibition of SERT, NRI and DRI. This brings about a question whether combining SSRI with Methylphenidate could somewhat potentially add to Methylphenidate's recreational value. Obviously enough, simply adding an SSRI to Methylphenidate would not make for Cocaine, as there are numerous difference's in how effectively Cocaine works on these receptors compared to Methylphenidate. But yet, adding an SSRI to SSRI naive users taking Methylphenidate for recreational purposes would account for all three receptors and possibly, in theory, could increase recreational value of Methylphenidate. In practice, things are more complex and actions of SSRI's on SERT as opposed to something like Cocaine should have their differences. Yet, the question remains whether the combination of high dose SSRI with high dose of Methylphenidate could somehow impact Methylphenidate's recreational value.

Are there any who might have had the same idea and tried it? How did it go? I have recently acquired some methylphenidate (which I've never tried before) and I have a prescription for Sertraline for my depression, which I'm taking, but have plenty enough saved up unused. I could try the combination by taking excessive dose of Sertraline at the same time as Methylphenidate but chronic usage of SSRI's lead to downregulation of post-synaptical serotonin receptors which might make the combination to produce different result than for those who are not using SSRI's for medical purposes at all.

I intend to try the combination myself, but it it could be assumed, that it would not be the same for SSRI naive individuals as for me. Any input on this would be appreciated.

 

[Vastness]

I'm pretty sure it's known that many SSRIs can lightly potentiate methylphenidate, I'm pretty sure I've used this exact combination a while back and was advised the same by a doctor... maybe I noticed something, but certainly nothing remarkable. Mind you these were with standard therapeutic doses. I really question the wisdom of trying to take a heavy dose of an SSRI for this purpose, I haven't done it but I believe extremely heavy doses can be somewhat dangerous and are mostly reported to be unpleasant. And methylphenidate is perfectly recreational on it's own, there's really no need to add an SSRI, I don't think it's gonna make it significantly better in any way really, unless you find SSRIs somewhat recreational in their own right. Whatever you're trying to do here could be achieved by taking just a little more methylphenidate than usual. Although since you've never tried it before, you should definitely start with just a normal dose. Take the SSRI (also in a normal therapeutic dose) at the same time, if you feel like it, or don't, it's really not gonna have any significant impact either way.

 

[Dextro .45]

I read a medical journal study stating its advantages and making it seem more “cocaine like” to stimulant users/abusers in the test studies

Methylphenidate is 3-4X more potent at DAT than NET ….adding an SSRI giving the combination the added Serotonin increase aspect that is lacking with MPH alone


However SSRI’s are nothing to be taking lightly …..funny enough.

Ritalin (Methylphenidate) is a relatively SAFE and mild stimulant as compared to more potent Amphetamines etc, over 20+ years on Ritalin and I NEVER had a single close call, worriesome increase in HR or BP in 50-70mg IR for 240lbs 6’ tolerance male

Vyvanse (Lisdexamfetamine) 40mg (12mg of d-Amphetamine) peak serum levels in 3h gave me slight, sporadic heart palpitations on several separate occasions and the drug was terminated ….a close friend same dose acting as the control also experienced same issues, noting heart palpitations…..a frequent cocaine user he is

Ritalin (Methylphenidate) is an amazingly euphoric effective and safe dopaminergic stimulant with a significant reduced liability to adverse effects compared to the Amphetamines….in low to moderate therapeutic doses….in my 20+ years taking Ritalin.

Only Oxycodone & Methylphenidate gave me TRUE euphoric bliss, warm blanket of comfort, supercharged talkative socializing being, confident, relaxed just pure fuckN sex……Ritalin & Oxy that’s it….Id throw in Valium, Xanax, Lyrica, Ethanol & premium cigarettes and that’s a rap

 

[awitha_teetha]

I take Ritalin everyday because I have ADHD. I used to be prescribed SSRIs, but I have bipolar disorder so SSRIs on their own don't really have any benefit for me and typically are just a boat load of negative side effects. I feel like this is important background because my brain chemistry very much effects my experience. When I was prescribed SSRIs, I would abuse my prescription and take 800+mg of Wellbutrin a day and then not take it for a few days and rinse and repeat. There's no beneficial recreational value, for me I just felt really flat or had really wild mood swings. I don't know if this is a common experience, but I actually ended up making my psychotic symptoms a lot more severe in this way, Zoloft specifically really brought on some of the worst delusions I've ever had. If you want to have a good time take some Ritalin and smoke some weed, that's my combo everyday that makes my life remotely liveable.