Stimulants Methylphenidate bioavailability.

[Gregor]

My friend has some 40mg XR Methylphenidate. We’ve just boofed some and it hits fantastic.
Way better than snorting and eating.

I can’t find anything about the bioavailability of plugging.
What would the bioavailability of different ROA’s be?
And how close does boofing come to shooting?

Thanks in advance

 

[Dextro .45]

Rectal administration is probably very safe & effective ROA …..bioavailability is pretty high. Injection of oral tablets is hazardous due to excipients, etc

Oral administration is pretty decent on its own, able to inhibit 50% of DAT at therapeutic doses (30-50mg oral IR) taken with a fatty meal (breakfast ham, eggs, toast, orange juice with MPH) aids obsorbtion…in addition taking Methylphenidate with ethanol increases concentrations of d-threo methylphenidate (Focalin) by 40% significantly enhancing euphoric properties in all study participants (medical journal) in addition to the INACTIVE l-ethylphenidate and ritalinic acid

So Ritalin orally with fatty meal and several ethanol drinks gin 2.oz + OJ each drink has Excellent oral bioavailability/absorption AUC & C-max

Intranasal administration of pulverized MPH has improved immediate rapid onset and peak serum levels (5min IN v.s. 30min oral)

IV injection would be 5 seconds….but unless it’s CIBA pharmaceuticals Ritalin 100mg / 10ml bottle of pure Methylphenidate HCL powder for injection it’s not really worth it….unless you conduct a competent extraction of MPH crystals / removal of all inert excipients and administer with micron filter first

Oral syringe for rectal administration…is very effective if at home in privacy

 

[Gregor]

Rectal administration is probably very safe & effective ROA …..bioavailability is pretty high. Injection of oral tablets is hazardous due to excipients, etc

Oral administration is pretty decent on its own, able to inhibit 50% of DAT at therapeutic doses (30-50mg oral IR) taken with a fatty meal (breakfast ham, eggs, toast, orange juice with MPH) aids obsorbtion…in addition taking Methylphenidate with ethanol increases concentrations of d-threo methylphenidate (Focalin) by 40% significantly enhancing euphoric properties in all study participants (medical journal) in addition to the INACTIVE l-ethylphenidate and ritalinic acid

So Ritalin orally with fatty meal and several ethanol drinks gin 2.oz + OJ each drink has Excellent oral bioavailability/absorption AUC & C-max

Intranasal administration of pulverized MPH has improved immediate rapid onset and peak serum levels (5min IN v.s. 30min oral)

IV injection would be 5 seconds….but unless it’s CIBA pharmaceuticals Ritalin 100mg / 10ml bottle of pure Methylphenidate HCL powder for injection it’s not really worth it….unless you conduct a competent extraction of MPH crystals / removal of all inert excipients and administer with micron filter first

Oral syringe for rectal administration…is very effective if at home in privacy

Thank you so much!

 

[emkee_reinvented]

Oral administration is pretty decent on its own, able to inhibit 50% of DAT at therapeutic doses (30-50mg oral IR) taken with a fatty meal (breakfast ham, eggs, toast, orange juice with MPH) aids obsorbtion…

They never told me that when taking that when i took that imo MPH crap. Is it due a combo: fat/ protein s/ sugars and acids. that the bioavailablity is bettered.

Afaic crappy pharmakinetics play a good role with this stim. A dose of 7.5 mg Oral gave enough side effects to not wanna go higher. heart palpitations and Anorexia. But within ~1:45 min i had to take another dose. or be faced by the rebound effect. That you wil have to face in the evening everyday. Exclusive to Ritalin non excist-ant with Amphetamines. Hence to me its crap. Or kiddy Coke at best

in addition taking Methylphenidate with ethanol increases concentrations of d-threo methylphenidate (Focalin) by 40% significantly enhancing euphoric properties in all study participants (medical journal) in addition to the INACTIVE l-ethylphenidate and ritalinic acid

Wasnt this a dead beat topic and no significant amount of dextro isomer is formed of clinical significance. And the combo is no more or less the same formula as Coke [were indeed a active metabolite is formed] but mainly about the abuse potential.

Not necessary better therapeutic effects. I would leave the Alcohol in case of ADHD. Better aim for XR dextro-Methylphenidate. When looking for a good Phenidate. Never had that it is made here by a pharmacist seems most promising form available to me.

 

[Dextro .45]

Those are legit medical journal studies with human participation……some cocaine users/abusers comparing to methylphenidate…..all are in-vivo double blind studies administering d/l-threo methylphenidate and they found a significant increase in d-MPH (40%) with ethanol coadministered which caused a marked euphoric pleasurable sensation

palpitations on Ritalin…..really. Interesting….I got those from Vyvanse (d-Amph) but never a single time with Ritalin 50-70mg IR and ethanol

Ritalin (Methylphenidate) is literally the safest dopaminergic stimulant….but I guess people reacted differently

Ya, they joking refer to Ritalin as “kiddy coke” as it’s prescribed to children…..however, another interesting fact….Methylphenidates ED-50 (effective dose to block/inhibit 50% of DAT) is nearly 2X more potent than Cocaine

And I stated that alcohol produced L-ethylphenidate ….not dextro. But the magic happens when ethanol increases concentrations of dextro-threo Methylphenidate (Focalin) which is euphoric as shit, alcohol & Ritalin have enhanced euphoria

Both Cocaine & Methylphenidate compete for the same binding sites at the monoamine transporters and have an identical MOA. Ritalin mg for mg is more potent than cocaine ….although has negligible effects at the SERT like cocaine has

Ritalin (Methylphenidate) and Preludin (Phenmetrazine) were highly sought after by high dose injection users for their powerful euphoric properties back in the 70’s when large volume API compounding powder was diverted onto the illicit market, especially when Phenmetrazine was voluntarily removed from the market by the manufacturer

 

[BorbOrB]

They never told me that when taking that when i took that imo MPH crap. Is it due a combo: fat/ protein s/ sugars and acids. that the bioavailablity is bettered.

Afaic crappy pharmakinetics play a good role with this stim. A dose of 7.5 mg Oral gave enough side effects to not wanna go higher. heart palpitations and Anorexia. But within ~1:45 min i had to take another dose. or be faced by the rebound effect. That you wil have to face in the evening everyday. Exclusive to Ritalin non excist-ant with Amphetamines. Hence to me its crap. Or kiddy Coke at best

Wasnt this a dead beat topic and no significant amount of dextro isomer is formed of clinical significance. And the combo is no more or less the same formula as Coke [were indeed a active metabolite is formed] but mainly about the abuse potential.

Not necessary better therapeutic effects. I would leave the Alcohol in case of ADHD. Better aim for XR dextro-Methylphenidate. When looking for a good Phenidate. Never had that it is made here by a pharmacist seems most promising form available to me.

Ive found low doses to be more undesirable than high doses. This went with Biphentin or Concerta and even Ethylphenidate. Seems quite paradoxical because you'd be getting more norepinephrine but at least in my experience I didnt have any anxiety or overstimulation when I upped the dosage substantially.

 

[awrt]

I have adhd and get prescribed dexamphetamine and vyvanse here in Aus.

I have tried ritalin and it definitely helped my symptoms but I always have an underlying feeling of anxiety in my stomach..same with concerta.

but with dexamphetamine or vyvanse I have absolutely no side effects.

 

[Greed420]

My friend has some 40mg XR Methylphenidate. We’ve just boofed some and it hits fantastic.
Way better than snorting and eating.

I can’t find anything about the bioavailability of plugging.
What would the bioavailability of different ROA’s be?
And how close does boofing come to shooting?

Thanks in advance

I have used all RoAs for methylphenidate (MPH) (brand medikinet XR 40mg) and I can do a rating of euphoria based on bioavaiability and RoAs

ORAL: BA 11-59% (mean 30%) 30min for onset at empty stomach, if took XR the effects last 6-8h, if crushed the beads and took IR it last 3-4h. Euphoria 2.5/10
SNORTING: BA 70% 5 min onset, 15-20min comeup 1.5h peak then harsh comedown with residual stimulation. Very similar to cocaine. Lasts 2-3h. Euphoria 6/10
BOOFING: BA 90-95% 5-10min onset, 5 min comeup followed by a rush of strong euphoria for 30-40minutes and then smooth stimulation for 2.5h. Euphoria 9/10 - THE best RoA
IV: BA 100% 30s onset, 1min comeup, 1-1.5h rush of euphoria followed by a smooth stimulation like boofing and easy comedown like boof. The most euphoric but the most harmful RoA, waves of pleasure all over the body and feeling of bliss. Euphoria 10/10

 

[HealingEnergy14]

Rectal administration is probably very safe & effective ROA …..bioavailability is pretty high. Injection of oral tablets is hazardous due to excipients, etc

Oral administration is pretty decent on its own, able to inhibit 50% of DAT at therapeutic doses (30-50mg oral IR) taken with a fatty meal (breakfast ham, eggs, toast, orange juice with MPH) aids obsorbtion…in addition taking Methylphenidate with ethanol increases concentrations of d-threo methylphenidate (Focalin) by 40% significantly enhancing euphoric properties in all study participants (medical journal) in addition to the INACTIVE l-ethylphenidate and ritalinic acid

So Ritalin orally with fatty meal and several ethanol drinks gin 2.oz + OJ each drink has Excellent oral bioavailability/absorption AUC & C-max

Intranasal administration of pulverized MPH has improved immediate rapid onset and peak serum levels (5min IN v.s. 30min oral)

IV injection would be 5 seconds….but unless it’s CIBA pharmaceuticals Ritalin 100mg / 10ml bottle of pure Methylphenidate HCL powder for injection it’s not really worth it….unless you conduct a competent extraction of MPH crystals / removal of all inert excipients and administer with micron filter first

Oral syringe for rectal administration…is very effective if at home in privacy

If you don't mind bowel or anal cancer then rectal administration of mucous membrane irritating substances is probably fine, most people are looking to be able to poop normally when they age though.

 

[Dextro .45]

Ya, than take in orally lol