N&PD Moderators: Skorpio | someguyontheinternet
Iversen et al. (2013) also reported submicromolar affinity binding of 5- and 6-APB and 5-IAI to h-Alpha2A adrenoceptors, but the significance of this is not clear. Simmler et al. (2013) and Eshleman et al. (2013) tested a series of cathinone derivatives against a range of h5-HT receptors and adrenoceptors but failed to find any potent interactions
Iversen et al. (2013) screened 14 drugs against a wide range of human monoamine and amino acid receptors in vitro and detected very few submicromolar interactions. The most notable finding was the high affinity binding of mephedrone, 5-APB, 6-APB and 5-IAI for 5-HT2B receptors.
I can't figure out if methylone is among the 14 drugs, but since both MDMA, mephedrone, 6-apb and 5-apb all have affinity to the 5-HT2B, I would find it strange if methylone wouldn't as well.
I have used it far to much since 2007, every weekend for several years, but about once a month the last couple of years. Going for a check up next week to see if any serious damage has been done.
sekio said:I'd bet that it still had affinity for 2b...
I would be very shocked if methylone did not act on 5-ht2b given the similarity to MDMA in action and the absolute requirement of 5-ht2b action for MDMA. The likely hood that two chemicals as structurally similar as methylone and MDMA that give such similar effects would work in two completely different ways if highly unlikely.
exactly. as much as i would appreciate the discovery of a new mechanism for pleasurable mdma-like serotonin release, i'd eat my hat of methylone isn't an agonist at 5-ht2b.
The APBs are stronger full agonists (some research indicates that MDA and MDMA are partial agonists at 5ht2b). This is only really an issue with chronic use, and this class of compounds absolutely cannot be dosed frequently (while maintaining positive outcomes).
ebola
If MDMA is reasonably suspected to cause heart valve hypertrophy even in casual users
When they say that the APB's and 5-IAI are full agonists, is that fact or hypothesis? Wouldn't you have to have the entire intercellular mechanism related to the receptor mapped and understood first?
A less neurotoxic version of MDMA should not be too good to be true.
A less neurotoxic version of MDMA should not be too good to be true.