methylmethaqualone

[General alcazar]

I still have a 5 gram bottle of this stuff. I was scared away by the seizure risk so never tried any. Still I am, I guess. I also have some etqualone left over. I didn’t realize that it could be vaped. Oral, it wore off very quickly, but I might try smoking some at some point. I remember qualudes from when I was a kid, but they disappeared right when I started to explore drugs. I really liked methaqualone when I tried it…. It was up there with pentobarbital and secobarbital, which I also only got to try a handful of times. No good downers around these days, at least for an unconnected individual such as myself.

 

[4DQSAR]

I think there MAY still be a handful of decent downers RC makers could go for. There are a couple of modifications to the glutethimide scaffold that MAY produce something similar but it's never going to be THAT potent and if that CYP2D6 induction remains (which is a reasonable bet given that other related compounds are known to), it's also going to see idiots taking codeine with it and harming themselves.

That's the thing. If your product is intented to be pychoactive, someone will ALWAYS ignore advice and dosis sola facit venenum.

If you drink alcohol in a pub, if you get too drunk they won't serve you any more. But if it's someone sat alone with a pile of powder, there is nobody sober pointing out that NOW is the time to stop.

 

[General alcazar]

I think that’s why the rc world had so few sedatives that weren’t benzos. I was surprised when all the fentanyl analogues started to be released, but even then, all benzos. Maybe the stigma of using these as rape drugs was the reason. After all, look what happened to GHB…

 

[4DQSAR]

BTW I have a hazy recollection of reading a paper that discussed the various homologues and analogues of methaqualone and it seemed as if ANY para substituent on that pendent aromatic resulted in much higher NMDA activity. I believe THAT is what produces seizures.

Methaqualone binds to something like 23 different subtypes of the GABA receptor (in addition to other classes of receptor). It was an agonist at some sites, a superagonist at some sites (which I suggest it what produces the euphoria) BUT was also an antagonist at some subtypes.

In that paper even the researchers admit that they failed to get a full picture of it's activity and as I've noted, it may very well be that methaqualone and a couple of homologues represent a 'small island of activity' i.e. you have to be very conservative in your choices. You have to actually test the stuff and understand both the acute and chronic toxicity of a novel compound. Get those urine samples and check what metabolites you have. Even then, you need a reasonably large cohort for any such study to be statistically valid. About 130 is a reasonable number.

But even then - you have to accept what is formally known as 'Stage IV trials' AKA pharmacovigilence. Even the minority that passed other tests can and should be yanked from the market if reports suggest bad outcomes may occur.

I know for sure that several potent examples of a class were abandoned because it was recognized that a customer under the influence may redose because their superego is repressed so they make bad choices. If those bad choices result in bad outcomes, it's inherently a bad idea. I was told someone tasted 100mg of pyrazolam and while they slept for a week, they were fine. It was expected, but it was also expected that someone might consume such amounts due to poor decisionmaking and/or as an act of self-harm.

Who knows how the people making carfentanil are able to dissociate from the fact that their product is almost certainly going to lead to very bad outcomes for others. Yes, adults, free will and so forth. I believe in the fifth freedom but I've posted a thread noting that the carfentanil has been catagorized as a WMD. I see little difference between that and openly selling weapons. I sincerely doubt a consumer is in a position to make an informed choice given that it's misrepresented as something else.

 

[krkkhed]

BTW Ephinazone appears to be a 'brand name' and from the little I've read is quite a bit less potent. But it does strike me that a LOT of related compounds were tested and methaqualone was the one that became a medicine. It does appear that this is what is termed 'a small island of activity' i.e. as you modify, you quickly run into compounds with MORE issues.

I was starting to think that when reading up on all the different analogues, all developed a while ago and never held up like methaqualone.
The product was just barely not white btw. Like its hard to explain but if you were to look at it in the bag it was off white and then completely white on surfaces or foil or my bowl. I spread it out on a space to inspect it at the beginning and it was white. In the bag off white maybe the bag is just doing it but it is a clear bag

 

[4DQSAR]

Well, while I am suspicious of a product not matching the description of known samples, I'm also wondering if 14mg is nasty, how come people would smoke multiple bowls of those other methaqualone homologues that turned up in South Africa? I accept that it isn't methaqualone but that extra methyl shouldn't alter the melting point by that much.

You have always seems a very sensible person so I guess I'm playing devil's advocate in part to eliminate issues when possible.