MiXEy + JWH or EtOH or Etizolam
Previously, I've combined MXE with Benzos, Alcohol or JWH Noids (and 25D-NBOMe, but that's a later tale). Although I hate cutesy names, I've taken to calling it "Mixey" due to it's amazing propensity to play nice with damn near everything that is thrown at it. Hell, MiXEy even goes well with poached egg, avacado, arugala and brie schmeared onto crispy bread alongside a mineral-dry white wine... eaten while lolling about a sun-drenched patio.
As a side note, identity and purity are critical to confidence in research, so at the time of receipt the MXE is split and sent on for testing by a consortium of purchasers; the few lots received so far have definitely been MXE.
All of the MXE mixes mentioned above were stellar. A typical MXE session consists of ~80-100 mg divided into 8 piles (10-12.5 mg). Typically, 37.5-40 mg is taken bolus, with 10-25 mg redoses taken at ~1-2 hour intervals until the piles are gone. Additionally, the accouterments (JWH, Alcohol, Benzos) are introduced at various points mid-flight.
ROA- Fingerprint/Toss-n-chase (p.o.):
It should be noted that the ROA for MXE here is per os (p.o.), specifically- a weighed pile of MXE is completely "fingerprinted" (pressed onto the fingertip in order to pick it up) and then transferred from the digit onto the back of the tongue and chased down the hatch with gulps of liquid (e.g. water, wine). Over a short time this ROA evolved and replaced insufflation of the fine, granular material, which had previously resulted in nosebleeds even when ground painstakingly fine (that can't be healthy). The employed p.o. ROA seems to be similar to the toss-n-chase that I frequently read kratom-heads utilize; or so I gather as kratom isn't allowed here. The p.o. fingerprint also replaced a few fleeting attempts at sublingual ROA, as absorption of dozens of mgs is physically impossible IMO. The hyperosmolarity produced by dumping dozens of mgs of salt-form MXE produces copious saliva, and it will not all absorb via the sublingual route. Sublingual claims for an amine salt compound dosed in the mid mg range is simply reedonkulous.
MiXEy with JWH:
As others have noted previously, the mix of MXE and JWH is very hard to titrate to a pleasant level and is fraught with the potential for an overwhelming experience. But imo JWH + MXE can be every bit as psychedelic as the classics, and the effort is well worth it. Imo, JWH019 works wonderfully, and is readily titratable (usually ~5-8 mg JWH019 vaped previous to the MXE comeup)... There is no anguish or terror or feeling that neurons have been scraped clean of all myelin. On the other hand, JWH210 (~3-6 mg vaped) can be a very overwhelming experience and a couple of times resulted in a repetitive, autistic-like "stimming" body movement repeated involuntarily for a couple of hours, followed by deeply slurred speech and confusion through the next day. It literally felt like I imagine the poor MPP+ parkinsons folks did back in the day in San Fran. Ugh.
Interestingly, if the JWH-210 is introduced at the end of the MXE run, it can be mind blowingly intense. A single, full vape of JWH-210 (which can't be much more than a mg or two actual absorbed, right?) can turn the MXE pleasant afterglow into a barrage of fleeting thoughts and fractalized mania. If the same JWH-210 amount is introduced during the comeup, there is a powerful experience, but not the unbearable autistic stimming movement and mania.
Bottom line- Suggested to stick with JWH-019, or 122 or 250 rather than the JWH-210 or AM-2201 uber-potent 'Noids when combining with MXE, so that the experience doesn't get easily out of hand.
That was all with vaped JWH. I've had one trial of oral JWH-019 (~6 mgs, dissolved in hot tahini sesame paste in the microwave) + oral ~20 mgs MXE, and this was so incredibly lush and euphoric and itchy-scratchy body feel that I've vowed to throw out the pizzo pipe/vaping apparatus and stick with oral routes for JWH when combining with MXE from now on (except when the JWH addition is spontaneously introduced in the midst of a MXE trip, then vaping is the only option to achieve the effect in a timely fashion).
MiXEy with EtOH:
Not nearly as psychedelic without JWH, but still a pleasant, euphoric body feeling... Alcohol mixes just waaaaay too well with MXE, and I agree with the poster above who noted that it cures hangovers. In fact, unfortunately, it also prevents hangovers, thus encouraging more ingestion of alcohol than I am really comfortable with. I really despise alcohol for it's gross, non-specific, solvent-like effects, but contrarily it's my favorite demon and it truly pairs well with MXE.
Typically, a liter of Cali pinot grigio is used to tip and chase the MXE down the hatch over the course of the evening. Maybe one liter-1.5L of 13% ABV white wine and 80-100 mg MXE sounds like a lot, idk, but it is usually spread out over around 6-8 hours or so. The feeling is of an initial alcohol warmth and euphoric rush... that just doesn't quit. Its almost like the MXE sustains the initial alcohol flush and doesn't let it get to the slobbery, slushy, toxic-feeling point. Eventually, the paired MXE and white wine result in a spaced out feeling, but not real tiredness. Which leads us to...
MiXEy with Etizolam:
Etizolam and MXE is nice, but milder than the aforementioned mixes. Perhaps it appeared mild because the combo hasn't been pushed to where it needs to be dose-wise, but benzo interactions and addiction are fearful beasts and for that reason this particular combo probably won't be explored that thoroughly over here.
One trial upped the Eti level to ~2 mg and MXE at ~30 mg, but this was largely a disappointment, as the benzo didn't heighten any of the introspective or visual aspects of MXE. It segued the MXE "trip" into a gentle, feel good, pillowy haze... The Etizolam shut down the insistent nature of the MXE thought process, such that it became corporeal rather than intellectual or spiritual. In essence, it seemed that Etizolam "aborted" the MXE magic in the same way it routinely does for Lucy, Boomers or the Shulgin's Pickles & Tickles.
Actually, Etizolam doesn't fully abort the MXE experience, it morphs it into a mellow, languishing euphoric body buzz that provides a solid counterpoint to the spaceyness of a MXE comedown and respite from the pushy thought processes. With this in mind, when Etizolam is utilized here it's most often simply to change the tone of the comedown from MXE manic-ville to nighty-night sleep time.
Falling asleep on MXE alone results in seemingly deep, but not restful sleep. Next-day naps are de rigueur after MXE flights, otherwise a nearly narcoleptic state ensues, including falling asleep at moments inopportune to professional advancement such as while talking to the Boss. Also, MXE-ified sleep doesn't seem to last longer than 4-6 hours, but that might simply be due to the onslaught of e-obligations that seem to pile up on any modern human who has the chutzpah to go incommunicado for a few hours.
But add in the Etizolam (absolutely limited to 250-500 ug [0.25-0.5 mg] buccal/sublingual, this is not recreational or abortive... it's integrative) and the MXE comedown becomes peaceful, the sleeping becomes restful. Paradoxically, it appears from limited experience that Etizolam helps negate the next-day narcolepsy as well. So, as for the other classic entheogens, with MXE the benzos (typified here by a non-benzo Etizolam) are being relegated to "comedown mode" only, and not recreation (ymmv). Actually, this is viewed in a positive light, as it would have been truly tragic to discover that MXE mixes stupendously well with Etizolam... Introduction of "Benzos" into a combination taken in a regular or routine manner is never good imo. I'd hate to find that I love a benzo combo almost as much as I hate to know that I love EtOH combos... but Etizolam has a special role to play for MXE at the final curtain call, and there it will stay. Etizolam will always be the bit player with MXE, yet Eti's role is essential and critical to piecing together the MXE matrix.