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Methoxetamine + Suboxone combo problems?

chrisinabox

chrisinabox

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I have been studying up on MXE because I want to try it, but I am currently on Suboxone for opioid dependence. I read in my MXE studies that it is a 'mu opioid agonist' as well as many other things, and diacetylmorphine(heroin), for example, is a mu opioid agonist itself, so that is why it worries me now after reading this....since I am on Suboxone and I cannot take other opioids and do not want to.

The real question I am trying to ask is will this MXE affect my regular suboxone dosing in any way? I've taken Ketamine many times intramuscularly with no problems if that makes any difference.

Thanks in advance for any help!

On a side note, methylone nor n,n-DMT will affect my Suboxone taking either, will they?

Peace.
 
I have taken suboxone with mxe, and subutex without any problem. I should note that I have a ridiculous opioid tolerance. I have also taken methylone less than 6 hours after taken buprenorphine without any issues. Can't comment on dmt, wish I could.=D I don't get any opiate feelng from mxe personally, but could be my tolerance.
 
i believe kets/mkets effect on the mu receptors is very minimal compared to the other effects of the dissociatives. There shouldnt be any problems, but i have noticed odd effects from combining suboxone and other drugs even drugs that have no effect on opiate receptors, like lsd, but thats prob due to the weird mechanism of suboxone on its own. Subs are funky pills thats for sure. Anyway thinking about it combining mxe and subs wouldnt be too bad. They might even compliment eachother. Do some first hand research :)
 
I've been doing research, but were would I do this 'further research', if you know?

Anybody else have any experience with mixing Suboxone and MXE or methylone or n,n-DMT?
 
^Thanks for the link. Unfortunately, it doesn't say anything about Suboxone & Methoxetamine combination at all, that is my main concern, seeing as how MXE has mu opioid receptor agonist properties, though low I suspect, it still makes me iffy in thinking about it, due to being on Suboxone.

I'd also like to know how methylone & suboxone interact and how n,n-DMT & suboxone interact, but my main concern is the MXE & Suboxone.

Anyone with ANY insight at all, would be GREATLY APPRECIATED!!
 
I think in general the best advice for when in doubt about any drug combination - don't try it. Every time I read something about someone getting hurt, ending up in hospital, or worse lately, it's been some weird funky combination they've tried out that not many people have tried/documented before.

I'd imagine it'd be easier to find reports of Suboxone + Ketamine than Suboxone and Methoxetamine, and given that both are relatively similar in their effects - you can assume that if Suboxone + Ketamine is dangerous, then Suboxone + Methoxetamine would be too.

From everything I know about their effect profiles I personally would say that it shouldn't be a bad combination but you should definitely take a lower dose of both than you normally would and definitely do NOT combine it with a high dose of Methoxetamine since this is still a very new chemical, and you have to be careful.
 
^Thx for reply.

So no one else has ANY experience with Suboxone & chemicals such as methoxetamine, OR n,n-DMT, OR methylone? I find that hard to believe.

So..last time, NO ONE has ANY experience with mixing, (or rather using the latter chemicals while on Suboxone Maintenance) the drug Suboxone and chemicals such as METHOXETAMINE (MXE), METHYLONE(M1), or N,N-DMT(SYNTHETIC)???????????????
 
Last edited by a moderator:
ywtf?? i thought i posted here earlier?? i LOVE suboxone + MXE. the MXE gives the sub the extra oomph to feel like a full-agonist. i have done both ways also, taking sub and then MXE, and taking MXE and then sub. you are good dude.

same with methylone as bk-mdma possesses zero affinity for MOR. you will be ok with both and will not go into W/D.
 
laCster said:
ywtf?? i thought i posted here earlier?? i LOVE suboxone + MXE. the MXE gives the sub the extra oomph to feel like a full-agonist. i have done both ways also, taking sub and then MXE, and taking MXE and then sub. you are good dude.

same with methylone as bk-mdma possesses zero affinity for MOR. you will be ok with both and will not go into W/D.
Click to expand...


Are you opioid dependent? I am not so much worried about using Suboxone and MXE at the same time, as using Suboxone AFTER MXE, seeing how it has 'some' mu opioid receptor agonism, THAT is why I was/am worried about possible precipitated withdrawal syndrome, which is why I opened this thread.
 
there is no clear scientific evidence that MXE possesses strong MOR affinity. you are fine...
 
Thanks for the reply, but that didn't answer my original/first question, were you opioid dependent when you took Suboxone right after MXE? last question I promise.
 
haven't done it but have done ketamine plenty. i have been on 4mgs a day for the last three years. no noticable change for me.
 
Yeah, me as well, with ketamine, but IIRC I don't think it has any mu opioid agonism, but I could be wrong..But MXE does have some, but enough to cause precip w/ds...is what I'm worried about..

Also, on a side note, how long is the duration of MXE in general? on Erowid, it says like 4-6hrs I beliieve, but I've heard from multiple others that have taken it and said it lasts like 12 fucking hours! Is this true or not?
 
Look at my post above.

So NOBODY knows the duration of MXE, via sublingually/buccally/IM/nasally? I thought it lasted 4 or so hours but I heard from multiple people it lasts 12 hours, is this true or not? Please, this is the last question I have.
 
The reason you're likely to have no replies, is because that should really be in The Big & Dandy Methoxetamine Thread - lots of people who can offer that kind of advice will skip over this thread just because they don't know anything about this particular combination.

Since your post is a few days old, rather than merging it with the Big & Dandy thread, I'll let you post there so your post appears on the last page :)

As for your question itself. Insufflation (nasal) is the worst ROA imo, shorter lasting AND less of a kick than the other ROAs, which is unusual for this ROA - probably due to the mucous membranes not absorbing much, but yes, it seems ineffective and a waste of material, so I always advise against it since why damage your nose if you get less high for the same material anyway? :) - As for the others, not tried buccal or IM, but sublingual the main effects tend to last around ~4-6 hours depending on the dose, with some residual effects for 2-3 hours after, and then you're left with the afterglow which can last anywhere from say 6-12 hours to 2-3 days. :)
 
I have had high doses leave me still having slight balance problems and residual stimulation a good 12 hours later with a good sleep.

Before trying IM, I thought snorting was the best ROA hey, just really loved it over the others but IM blows it out the water.
 
hi,

i think suboxone and mxe a good combo (i take opioids for 6 years), ihmo: mxe and zopiclon is also a a nice mix.
and all the time i konsum it with jwh-x or an AM flavour, no problems and i only search on weekend.
 
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