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Methoxetamine Stopped Working

B

Bluewave

Greenlighter
Joined
Sep 20, 2009
Messages
17
I've been using methoxetamine daily for the last month. Usually 100-150mg over 2-3 hours (my tolerance has built up from an average of 50-75mg)

All of a sudden, this weekend mxe stopped working. On Friday I noticed much reduced effects, even after an extra 50mg bump. The next day I went through what I had left, 300 - 400mg with no effects other than confusion and memory loss.

I ran out this Saturday and haven't ordered any more. I don't really feel like myself and haven't for a couple weeks now.

I'm taking mitrazepine in addition.
 
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It's called tolerance... and it happens with every drug after a while.

I've been using Methoxetamine daily for the last month.
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How do you not see anything wrong with this? It's methoxetamine by the way - it's not an amphetamine, it's an arylcyclohexylamine closely related to ketamine and tiletamine.
 
Welcome to my world, tolerance sucks and it doesnt go away with dissociative's (unless you want to take a year off and there's no way I could do that).

With MXE i usually had to do 100mg to even feel anything, but I could easily do 400mg in a day. But with K my tolerance is so high that a gram last me a couple hours.
 
Mirtazapine? You were taking mirtazapine along with an NMDA Antagonist? Hmm. Ever heard of Olney's Lesions? It's still debated as to whether or not they actually occur in humans, but there are theoretical drugs to prevent Olney's Lesions when using NMDA antagonists. These include anticholinergics, benzodiazepines, barbiturates and agonists at the alpha-2 adrenergic receptor. Note that mirtazapine is an alpha-2 AGONIST. Theoretically, this would increase the risk for Olney's Lesions when using NMDA antagonists. Please, be careful. Perhaps you should reconsider your MXE use. I wouldn't recommend ordering any more. Wait a few weeks/months and see if you start to feel normal again.
~snr
 
sekio said:
It's called tolerance... and it happens with every drug after a while.


How do you not see anything wrong with this? It's methoxetamine by the way - it's not an amphetamine, it's an arylcyclohexylamine closely related to ketamine and tiletamine.
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Yeah hopefully that's all it is. I've read a few scary journal articles and my memory doesn't seem right.

I'll fix the spelling mistake thanks
 
Your memory doesn't seem right because you've been abusing a dissociative drug daily. Give yourself a month to get it all out of you and you'll be fine.
 
You should probably quit for good, that's some seriously self destructive and compulsive behavior.
 
You're right QuasiModo I liked mxe a little too much.

Self destructive.. I did have good intentions, I heard drugs such as ketamine could work as a treatment for depression and I've been having issues with that for a couple years now.

I had a scary experience towards the end of my month of constant use. The effects of mxe had seemed to have worn off so I decided to go visit a friend about an hour drive away. When I started driving though it was obvious that I was still under the influence so I pulled over and parked off the road. I stayed in the car for about ten minutes deciding what I should do and in the end I left the car in the parking lot and started to walk home, I was under a kilometer from my house and didn't think of calling a cab.

I couldn't seem to figure out how the streets connected off the main road and ended up getting "lost" about 500 metres from my own house. After a bit I tried to use the GPS on the phone to figure out what direction I should be heading in, but got confused with that too. Eventually I asked someone directions and got home after about two hours.

I also had an issue where I'd have no trouble falling asleep but woke up for work with red eyes feeling like I hadn't slept at all.

I'm shocked that nobody questioned my behavior at work. For example, someone asked me if they could come pick something up from my office. I asked this person the next day why they didn't stop by and they had already picked it up. I have absolutely no memory of this and wasn't even using mxe at work.

Is it possible mxe has a metabolite with a long half life?

Seiko thank you very much for the positive thoughts.

SNR if I start thinking that I have brain lesions I'll drive myself nuts. Not to be argumentative but we don't even know the effect of coincidental use of caffeine on a substance like this.
 
I'm glad you can see clearly that this isn't healthy for you. I have a close friend who recently spent his last $550 dollars on Ketamine. He had been out of contact with me for a few months, every time I would call we would make plans to meet up and he wouldn't show. I saw him coincidentally at a show last night and his behavior worried me. I have now crossed Ketamine (and all other disassociatives) off of my list of substances to try, my friend has become addicted and it is clearly affecting his cognition and psychological health. I hope for the sake of your loved ones that you do not wander down this destructive path for too long. Disassociatives scare me.
 
Why are you people using this drug every day? First of all, its a research chemical, second of all its just plain dumb. But yeah, its called hardcore tolerance.
 
Bluewave said:
I've been using methoxetamine daily for the last month. Usually 100-150mg over 2-3 hours (my tolerance has built up from an average of 50-75mg)

All of a sudden, this weekend mxe stopped working. On Friday I noticed much reduced effects, even after an extra 50mg bump. The next day I went through what I had left, 300 - 400mg with no effects other than confusion and memory loss.

I ran out this Saturday and haven't ordered any more. I don't really feel like myself and haven't for a couple weeks now.

I'm taking mitrazepine in addition.
Click to expand...

you should probably take a big break and get your tolerance back down

however.

are you still just taking 50mg bumps? maybe you need to do bigger bumps. 100mg at once hits quite a bit harder than 50mg now and 50mg in 20 minutes.
 
I've decided not to use mxe at all for awhile either for at least a month (maybe never). It's likely possible that if evidence comes out that it actually does cure depression like ketamine I will take the bag back out of the "sin bin". I'm lucky enough to have a good health plan so I made an appointment with a registered addiction psychologist today to discuss what went on all September.

@Bone14 I have a tendency to use something I like the effects of every day. For something like coffee that is ok, for other things it isn't. For some reason a lot of the time I don't care until something like this happens.

I did have some very interesting experiences. A couple times I did take 100mg at once. The whole room started shaking and I assumed the my apartment had launched itself into orbit. Also had a experience where I was in a space capsule going to another planet after finding out that human life was one big biological experiment by a more advanced society. A couple of experiences also where I thought I was dying that I'm not comfortable talking about right now.

I'm still having some memory issues, for example I went to a conference on Wednesday and I don't remember the name of most of the people I was talking to. I'm also getting almost nothing accomplished at work because I feel tired, unmotivated, and unfocused.
 
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I'm still having some memory issues, for example I went to a conference on Wednesday and I don't remember the name of most of the people I was talking to. I'm also getting almost nothing accomplished at work because I feel tired, unmotivated,
and unfocused.
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do you have these memory issues still in 2013 ? I noticed same problems and dont know how to resolve that.. do you stopped taking mxe? I have 3 month break but still feeling abused :(
 
klinick said:
do you have these memory issues still in 2013 ? I noticed same problems and dont know how to resolve that.. do you stopped taking mxe? I have 3 month break but still feeling abused :(
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Keep off it, eat healthy, exercise, and exercise your brain too (spend time reading, writing, debating, etc). NMDA receptors are involved in memory and learning and as such abusing them with these dissociatives can have a negative impact on these faculties.

The exact extent of this damage and whether or not any of it is permanent or if it all resolves with time is as yet unknown as far as I'm aware, but time and living a healthy lifestyle will certainly improve things at the very least - even a healthy mind can still be improved, so it goes without saying that one that's been abused can too. :)

Also, you say a 3 month "break", the terminology here worries me, I might be wrong but to me that suggests you're planning to return to it as soon as you feel a bit better.. If you've noticed these kind of serious problems then I'd recommend a MUCH longer time off the substance if you ever do return to it at all.

Are you still taking other drugs? While it can understandably be a hard decision to cut down/stop everything all at once, if you're experiencing these kinds of problems it'd be for the best. Other drugs like stimulants and Cannabis can negatively impact memory and learning when abused, so if you're continuing to use them during your break from MXE then they'll very much slow your recovery.

Feel free to ask any more questions that you feel might help you. Also do check out Healthy Living, I'm sure they could give you some great tips on ways to improve your memory over there, if it's being a problem for you. :)
 
FYI ketamine doesn't "cure" depression. It has been demonstrated to lessen the severity of such, in very small doses, for anywhere from a few hours to up to a week. Huge doses likely have the opposite effect. So, your logic that taking HUGE doses DAILY of an entirely different unresearched drug is faulty, as well as dangerous and downright stupid. Stay off it, exercise, and eat well and you'll feel much better in a month. That's the best prescription for depression IMO anyhow, exercise, lots of it, healthy diet, and leading an engaged life. Wandering around in a dissociated haze is only going to make things much worse.
 
Depression is not something that can be cured. It's a state of mind, an emotion. Such as "I'm happy!". You can't cure yourself from an emotion, can you? lol.

Take a few months off and you'll be fine. The human body has an unbelievable ability to heal itself through time and sobriety.
 
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