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Methoxetamine + Buprenorphine

MONSTA!!

MONSTA!!

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Hi,

I I'm currently on buprenorphine maintenance (22mg per day), I would like to know if this is likely to affect/interact with Methoxetamine and also whether it would be wise to combine the two.

Any info would be greatly appreciated.

MONSTA
 
You could get bradycardia easily if it's methoxamine you're thinking of.
-> Other Drugs, it's not ADD for sure
 
I think he is on about Methoxetamine as it is a recently available analogue of ketamine rather than the adrenergenic agonist methoxamine.
 
hx_ said:
I think he is on about Methoxetamine as it is a recently available analogue of ketamine rather than the adrenergenic agonist methoxamine.
Click to expand...

That's exactly what I'm referring to.

adder said:
You could get bradycardia easily if it's methoxamine you're thinking of.
-> Other Drugs, it's not ADD for sure
Click to expand...


I've posted this here as I believe both these drugs bond to certain opioid receptors in the brain (Kappa, Mu?) so as this question touches on neurochemistry I'm likely to get a better response in ADD.
 
(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) is what is being sold as methoxetamine.
 
(2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone) is what is purportedly being sold as methoxetamine.
Click to expand...
Fixed.

I feel sorry for fnb, he can't write a trip report without starting off a drug craze.
 
During my work on analogs of phencyclidine I tried 1-[1-(3-methoxyphenyl)cyclohexyl]piperidine and it was very similar to PCP in potency, however 3-[1-(piperidin-1-yl)cyclohexyl]phenol was ~8x as strong as PCP and now this had a serious potential at opioid receptors. Anyway, it doesn't really feel like you took a regular opioid. 3mg of it wiped me out.

But this - I don't know, a carbonyl group here always makes a compound of shorter duration but with enhanced analgesic properties. It's no fireworks here, I guess. An amino group up there instead of methoxy would be way better.
 
Can you please share your experience, if any, with the combination mentioned above. It would be much appreciated to hear whether or not the bupe blocked all or some of the effects of methoxetamine.
 
Opiyumphile said:
Can you please share your experience, if any, with the combination mentioned above. It would be much appreciated to hear whether or not the bupe blocked all or some of the effects of methoxetamine.
Click to expand...

Why would it?

Assuming (and it is purely an assumption on my part!) methoxetamine's pharmacological profile is very similar to Ketamine's, bupe is not going to have any effect on binding at NMDA, nACH, the dopamine transporter or D2 receptors.

Ketamine does, I believe, have mu opioid activity at high doses... so if methoxetamine does as well I suppose it could alter the effects at high doses though I don't know if this would actually alter the subjective experience or not.

Respiratory depression could be an issue though:
http://www.ncbi.nlm.nih.gov/pubmed/10817461
 
Mudeltakappa said:
Why would it?

Assuming (and it is purely an assumption on my part!) methoxetamine's pharmacological profile is very similar to Ketamine's, bupe is not going to have any effect on binding at NMDA, nACH, the dopamine transporter or D2 receptors.

Ketamine does, I believe, have mu opioid activity at high doses... so if methoxetamine does as well I suppose it could alter the effects at high doses though I don't know if this would actually alter the subjective experience or not.

Respiratory depression could be an issue though:
http://www.ncbi.nlm.nih.gov/pubmed/10817461
Click to expand...

Perhaps you are correct I don't know. I guess I saw that some part of methoxetamine's effect was mediated by the opioidergic system and I assumed that it could alter it's effects or completely block them.
I took this from the fact that Salvia, in the past, had been rendered completely inactive by bupe. Salvia is just Kappa though huh...I don't know.


Anyway we'll just have to see for ourselves tomorrow what effect, if any, bupe has on MXE.

In any case I hope you're right.
 
Wow...a 4 milligram, snorted, allergy test has actually produced a fair amount of activity. Certainly not being blocked.
Feeling oddly drunk. Drunk in an odd way that is.
 
^ Please keep us posted how methoxetamine reacts with buprenorphine.

If the buprenorphine seems to have little effect on methoxetamine would that mean that daily use of any opiate, such as fentanyl or oycodone, would have little effect on methoxetamine?
 
Hmm...
The above post must have been due to placebo.

25mg (+/-2mg) was administered intranasally at 10:05 pm.

it's now 10:57pm and all I can say is... meh...not much happening...I'm in placebo limbo...nothing is standing out...nothing distinct that I can point to but I do have the sense that I am on the edge of something....
...I'm debating taking more because clearly I'm not baseline but neither.... ... ...

ok....never mind it's actually only now hitting me....at +1hr

11:06..ill redo this later....


EDIT: 2:25am

Okay for the most part I'm back to baseline. That was interesting. I sincerely logged on here to post that either what I got wasn't legit or the bupe had blocked the effects but as I was typing the first part of this post (everything pre EDIT:2:25am) it really did start to hit me in a way that couldn't be placebo. Whereas everything I had felt prior to that could have just been normal phantom sensations that people get all day every day in a normal state of mind.
Anyway...As I said I took roughly 25mgs +/- 2mgs intranasally and I feel like I got a good introduction to the experience but I definitely want to go further. Not really any time distortion and no dissociation at all. I'll just post a couple excepts from my notes on the experience.

+1hr15min - Warm Electrified head, tingly goodness, light euphoria in waves.
+1hr30min - Warm Opiate glow, especially in legs
+1hr35min - Thinking of old friends, feeling great deal of empathy, does this stuff mimic every aspect of every drug ever?
+2hr - went to bathroom, motor skills inhibited a good bit, a touch of nausea
+2hr30min - Smoked some JWH-018 laced herbs, intracranial pressure but good, feels like a warm massage on my temples, entire head numb
+3hr - reminiscent of a heroin nod, even with loss of coordination still capable of playing guitar, (*actually had a bit of a breakthrough finally being able to count while playing something in 5/4 that I've been having trouble with)
+4hr - ulcer in mouth irritating me again, definitely coming down, no crash, feeling somewhat rejuvinated actually...
*wasn't actually in my notes


All in all a great experience. It reminded me of a large variety of drugs at different points. Sometimes it reminded me of what it feels like ten seconds or so after pushing down the plunger of a needle full of good heroin(kind of a scary prospect now that I'm sober quite frankly). Some parts reminded me of mescaline acetate/MDMA/LSD/DMT/NO2 trippyness, and other parts were like the spins you get after way too much drinking and a bong hit. That going fast while standing still sort of feeling....

I would have to draw the same conclusion that GlassCage did in his post found here. The only difference is instead of Methoxetamine 'being unlike any drug I've ever taken' it's actually more like a combination of every drug I've ever taken...at least at the dose I just experienced. I do look forward to a larger dose to see how it differs. I think next time I will try 35 milligrams.
 
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Methoxetamine effects are certainly in part due to opioid agonism. Any analog of phencyclidine with -OH, -NH2, or -OMe group on meta position on phenyl ring has some opioid activity, e.g. 3-OH-PCP and 3-amino-PCP both cause well pronounced opioid-like effects, in comparison to straight PCP they're a few hundred times as potent in this respect. Subjective reports that can be found here support that for methoxetamine ( 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexanone ).

I've found some binding affinities in my files (I can't find more, and different sources give different affinities, I had some for buprenorphine as well):

Code: 
Table 4: Summary of Binding-Affinity Data
Compound                                    Ki (nm)
                                      Delta    Kappa      Mu
Hydromorphone                           172       99      0.26
Dihydromorphine                         212       38      0.39
Dihydroisomorphine-6-glucoside          868      440      4.7
Hydromorphone-3-glucoside               4500     2400     51
Morphine sulfate                        284      268     14.3

Source: SUGAR DERIVATIVES OF HYDROMORPHONE, DIHYDROMORPHINE AND
DIHYDROISOMORPHINE, COMPOSITIONS THEREOF AND USES FOR TREATING OR
PREVENTING PAIN

Knowing buprenorphine will force out all of above mentioned from receptors, one can also tell buprenorphine will force out methoxetamine for example. Then the drug will rely on its sigma agonism and NMDA blocking properties. But that's all theory.
 
I guess there is no way for me to know if the effect was being altered or not since I can't make a comparison to taking without the bupe. I can say it sure doesn't seem like it was altered or diminished in any way.
And I was clearly reminded of full on Mu agonist goodness.
I was really worried about possible precipitated withdrawals or just getting no effect but that wasn't the case.
 
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Old thread but I'm tired of the MXE is an opiate myth so I have to reply anyway: MXE does not have any affinity for opiate receptors. Source: https://www.gov.uk/government/uploa...chment_data/file/119087/methoxetamine2012.pdf

Inhibition of SERT is likely what causes MXE's opiate like warmth. But it is not an opiate and therefor does not have withdrawals. For an ex heroin addict like me it's pretty easy to tell the difference between the two in effect. The warmth from the arrylcyclohexylamines feels different from the one caused by traditional opiates. It much more resembles MDMA to me.
 
Toz said:
Old thread but I'm tired of the MXE is an opiate myth so I have to reply anyway: MXE does not have any affinity for opiate receptors. Source: https://www.gov.uk/government/uploa...chment_data/file/119087/methoxetamine2012.pdf

Inhibition of SERT is likely what causes MXE's opiate like warmth. But it is not an opiate and therefor does not have withdrawals. For an ex heroin addict like me it's pretty easy to tell the difference between the two in effect. The warmth from the arrylcyclohexylamines feels different from the one caused by traditional opiates. It much more resembles MDMA to me.
Click to expand...

uhm... thanks for the affinity chart , i've been looking all over for one.

so it says "Opioid Receptors: AFFINITY:
MOR, KOR, DOR"

mu opiate receptor affinity, kapaa receptor, and delta receptor. it DOES have opiate receptor affinity. I be a mythbuster, yo.
 
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Those were the receptors that were tested, not the receptors MXE was shown to have affinity for. None of the ketamine analogues have appreciable mu/delta/kappa binding.
 
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