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Methods of Administration - DXM - IV and IM vs. Oral

JasperTheReckless

JasperTheReckless

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Nov 1, 2011
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I have heard mixed things about IV and IM DXM and it's effectiveness.

Firstly, is IV or IM admin of DXM possible, and if so, is it particularly harmful?

For the sake of the experiment, it's with 98%+ purity, not something derived from cough medicine.
 
I think IVing DXM is going to hurt terribly. It's very caustic. I don't know much about IVing though. There is the DXM FAQ which probably will tell you more. The thing is you can get so incredibly high off oral, is it really necessary?
 
Just from reading terrifying reports of rectal and intranasal use I would steer very clear of trying this. Don't forget also that liver metabolism is an important part of the DXM experience and oral consumption is best for this.
 
Transform:

The Liver metabolizes it into DXO, with I am not a fan of. I usually chomp a few grapefruits.

I am not putting up my bum, as i'll damn ear shit myself to death from what I hear, and snorting it isn't an idea either.

I read a report of 100mg IV on Erowid, and while I trust that site, I trust BL more.
 
Fair enough if you prefer the DXM only experience but to me the rectal and nasal experiences are big, flashing warning signs. Veins don't have pain receptors so it's down to the conscious brain or the gut to screen anything entering them.
 
I usually chomp a few grapefruits
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Grapefruit is a much stronger inhibitor of CYP3A4 than 2D6 to my knowledge, so it still encourages higher levels of DXO as a metabolite than 3-methoxymorphinan or whatever.

I wouldn't inject the stuff, if it's horrendous nasally/rectally, it's not something you want to be putting in your veins/muscular tissue.
 
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What's the best/easiest to obtain inhibitor? Orally would be fine if it was simply more effective.

I cannot find anything other than Fluoxetine, or paroxetine on google.
 
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I think you might be confused. By my understanding grapefruit would result in higher levels of DXO as never mentions above. Are you after the NMDAR antagonist effects (of which DXO is much more potent of an antagonist) or the SERT and NET inhibition effects? And, finally, why?
 
The report on erowid you're referring to is for DXO, not DXM. IIRC it was also sent in by someone with access to a lab, a chemist student I think. They reported having an awful time.

DXM has to run through the liver to become active (most converted to DXO, some remains DXM). IV roa will by-pass the liver. That alone would make me not want to inject it but there is also the problem of it begin a corrosive substance.

So, stick to the oral ROA. If tolerance is an issue you should take a break from it.

If you're looking for something similar that you can IM/IV than pick up some K or MXE. Those would be way safer through those ROAs than DXM for sure.
 
I am pretty sure DXM has a really poor oral BA, so IV doses in theory would probably be a tenth of oral doses, or less.

Be very careful though - as others have noted DXM is not very vein safe.
 
I suppose if you had enough time and money you could formulate a propofol-esque emulsion of dxm that was fairly fein safe. But that's a pipe dream, as others have said, find a better dissociative to play with, or just eat your DXM
 
Ah yes, I had completely forgotten that DXM.HBr is rather insoluble in cold water.
 
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