• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Methcathinone synthesis byproducts

Status
Not open for further replies.
Jenerate

Jenerate

Bluelighter
Joined
Aug 26, 2007
Messages
174
If you follow the methcathinone synthesis on erowid (using potassium permangate), what toxic byproducts end up in the final product?

I've read that benzaldehhde and manganese could be two of them. Are these likely to be present? If they are, would you absorb them if you vaporised the methcathinone rather than taking it orally?
 
We don't do this kind of shit here man. Go find a local meth lab on your street and go cause crime with them. BlueLight=0 tolerance for crime and this sort of silly shit. I'm sure this thread will be closed. I suggest you read the forum rules as well as the bluelight user agreement.

Peace.
 
chill a second, hes asking if its goin to be toxic or not

you contribute nothing to this thread by tellin him that...i also contribute nothing as well, but damnit man this is harm reduction stuff

if hes goin to do dumb shit, he can do the dumbest ssafely as possible eh?

anybody else got some input if this shit is harmful to the guy?
 
I just don't know what's going on. Ryan Seacrest and I were just hanging out drinking ginger ale and I found myself here.
 
Firstly, I'd like to say that I'm not asking how to cook up methcathinone.

Could I get a purer product by adding sodium hydroxide to the methcathinone HCL after the acetone wash, dissolving this in naptha or dichloromethane and then evaporating the non-polar solvent off to leave methcathinone base (which could be vaporised)?
 
I'm moving to ADD, if they're okay with it, it can stay there.
 
Jenerate said:
Firstly, I'd like to say that I'm not asking how to cook up methcathinone.

Could I get a purer product by adding sodium hydroxide to the methcathinone HCL after the acetone wash, dissolving this in naptha or dichloromethane and then evaporating the non-polar solvent off to leave methcathinone base (which could be vaporised)?
Click to expand...

Or would I be right in saying that benzaldehyde is non-polar and would therefore dissolves in the non-polar solvent?

If so, should I add dichloromethane to a solution of methcathinone HCL, which would dissolve the benzaldehyde and separate off the aqueous solution (and let the water evaporate off)?
 
Jenerate said:
Or would I be right in saying that benzaldehyde is non-polar and would therefore dissolves in the non-polar solvent?

If so, should I add dichloromethane to a solution of methcathinone HCL, which would dissolve the benzaldehyde and separate off the aqueous solution (and let the water evaporate off)?
Click to expand...

A non polar extract of solution would remove some of the impurities.
TBH I am not sure what the impurities are, I would imagine there is also some cyclic junk and some ketone and some nitrone along with coupling products.
recrystalising the methcathinone HCl from isopropanol or alcohol would purify it greatly. the manganese is not very soluble in water so is unlikely still to be around.

methcathinone is soooo 1990's!! :) it was crap then and is crap now, only now it is crap AND illegal.

this is getting rather close to the line...
V
 
Methcathinone synthesis via KMnO4 oxdn. may yield Mn2+ ions and MnO2 as impurities. Some methcathinone dimer can be formed from cyclization. Some benzaldehyde from accidental cleavage can be expected, as well.
I suggest purification via basification and extraction with a non-polar solvent. Make sure you only hold the MC in freebase form for as little time as possible, dimerisation is much more rapid in this form - basify, extract, and then acidify it again as soon as possible! You WILL lose a significant quantity to cyclization otherwise!

Oh, by the way, there are better oxidants you can use than permanganate that are less harsh and easier to clean up. Each to his own though.
 
MattPsy said:
Oh, by the way, there are better oxidants you can use than permanganate that are less harsh and easier to clean up. Each to his own though.
Click to expand...

I don't give a shit about methcathinone, but just out of curiosity what would be better? Chromic acid/chromate?
 
MattPsy said:
Some methcathinone dimer can be formed from cyclization.
Make sure you only hold the MC in freebase form for as little time as possible, dimerisation is much more rapid in this form - basify, extract, and then acidify it again as soon as possible! You WILL lose a significant quantity to cyclization otherwise!
Click to expand...
I don't think the dimerization is a major problem with secondary amines. It has been discussed here:
http://www.bluelight.ru/vb/showthread.php?t=244907&highlight=cathinone

johanneschimpo said:
I don't give a shit about methcathinone, but just out of curiosity what would be better? Chromic acid/chromate?
Click to expand...

It doesn't make a difference. The oxidant is chromic acid in either case. For reference, refer to "Jones Oxidation" in an O. Chem. text.
 
reply to hussness

Thanks. I wasn't asking which was better between chromic acid or chromate, I'm aware that in a rxn like this the chromate will form chromic acid which does oxidation (forgive my shitty terminology)... what I meant was is chromic acid (from chromate) better than KMnO4.
I'm pretty sure I know the answer though, so I don't even know why I asked.
 
Theoretically the dimerisation shouldn't be a problem :(
But it still happens. In base form it seems to form a orange product, which is inactive. I really can't think of any other reaction that would produce this result.

And yes CrO3 (chromic acid) is superior to permanganate (and dichromate, too, because dichromate is overly harsh as well).
 
There are other oxidizers that could be used. Perhaps even sodium hypochlorite in the the 5% version available as "bleach" (so long as you also have some GAA). Of course ACS or USP grades are better to use, but chances are you dont have the access (especially if your considering the synthesis of a stimulant as shitty as MCAT).

Might as well do a dirty Nazi cold cook (involving dry ice, ammonia etc - can't expand upon that here) on the pseudoephedrine and make something more worthwhile (d-meth). That shit is still dirty, unless your have good reagents and means to test purity.

Thats about how far i'll get into synthesis here.....
 
Status
Not open for further replies.
Top