Methamphetamine + SNRI + DRI (ADD users only please)

[AMet(h)ly]

OK, I KNOW KNOW, please read before you light me or this thread on fire..

So ive read the rec combo threads, all over the place. ive seen meth + this, meth + that, but i havent seen:

METH + SSRI + NRI + DRI (or in other words, SNRI + NDRI)

now ive tried lookin all over da place for this. the closest thing similar ive found is a thread on SSRI/SNRI's on regular amp and SSRI/SNRI's on MethylDIOXYmethamphetamine or mdma. we know mdma is a nono, but amp is ok. so im stuck in the middle, not knowing about this combo with meth, and imean low doses of meth too, like less than half a point, a mini matchead bump if u will, lets say for arguments sake 25-50 mg of meth.

First please look at it from a seperate combination interactions if possible:

[METH + SNRI] and then [METH + DRI].

would the SNRI (effexor, cymbalta, etc...) with meth be more similar to the effect on MDMA or AMP, since there is a serotonin release? or would this cause serotonin toxicity instead of serotonin neuroprotection that SNRI's have on mdma and amp. now it may also cancel out the serotnoni aspect of the meth, causing it to be mainly a dopaminergic experience, but then again, i wouldnt know. so basically would the SNRI be protective like with amps and mdma (though cancelling sert part) or would it be nuerotoxic (because of meths sert part)

now, would the NDRI (obviously wellbutrin) dampen the dopaminergic euphoria of the meth or would it keep it at a safe level of dopamine, while the NE reuptake would prevent too much NE release, for a less TWEAKED!!! and sinmply more euphoric ride? also, would this mediate any NE/DA neurotixicy, if it exists at all with such a dose of meth?

Now if you these are explained (the SNRI+METH and NDRI+METH mixes) seperately, we can probably deduce what it would be like if you mixed the three together, Meth+SNRI+DRI, but sometimes different combos yield different than expected results. so what would the total mix of the 3 MA reuptkae inhibitors due with such small amounts of meth

ANyway, would fairly low dose reuptake inhibitors (AD's) work well, cancel out, enhance, neuroprotect or Toxicify low dose meth.

Thanks for the input

 

[TheLoveBandit]

ANON to ADD

 

[ebola?]

You would need high binding-affinity reuptake inhibitors...but ones that aren't so potent as to actually eclipse meth's releasing propensities. Wellbutrin is highly inappropriate, as its binding affinities are too low.

Your plan works out well with most any selective SSRI.

I forget which NERI would be appropriate, but I believe that Reimann Zeta knows one that works well.

I'm not sure what you're trying to do with the DARI added in (for the combined effect of all three moderating RIs). Do you wish to cancel all of meth's effects?

ebola

 

[AMet(h)ly]

re: Methamphetamine + SNRI + DRI

ebola thx 4 tha postz.
i noticed riemann zetas postz about ssri and ampz.
i thought itz diffrent 4 meth tho.
i think it was actually him dat sed its 5x the serotonin.
haha I def dont wana to kill the fx but low doses on RI's
(u point out Wellbutrins da affinity is not that strong newyz)
could proly really not like make use 2 bad rite?
to like ween off, redux in habit gradually, while not doin xtra damage
n whenever used, ur safe? its like a win win. lol

 

[wreckhead]

As far as I understand it, adding the DRI in would serve only to inhibit the synaptic DA release mediated by meth, although meth doesn't release much serotonin so the same wouldn't apply to the SSRI. However, unless you've been taking the SSRI for >2-4 weeks, it wouldn't give you the increased synaptic serotonin you want, instead hitting 5-HT1A and other autoreceptors to decrease serotonin.

Basically, I'd say attempt meth + NRI + SSRI, but only after being on the SSRI already for several weeks. Forget the DRI, or replace meth with it altogether.

 

[flacky]

Mixing antidepressants with chemicals like Meth is bad idea in general.

 

[ebola?]

although meth doesn't release much serotonin so the same wouldn't apply to the SSRI. However, unless you've been taking the SSRI for >2-4 weeks, it wouldn't give you the increased synaptic serotonin you want, instead hitting 5-HT1A and other autoreceptors to decrease serotonin.

1. Meth does effect substantial release of 5ht (but dwarfed by other effects).
2. The point of the concurrent SSRI is to crowd meth out of SERT and block the transporter, thus preventing SERT from taking up dopamine in the wake of 5ht efflux (effect noted in point 1), which is thought to contribute to neurotoxicity.

The OP might also want to prevent the mental effects of 5ht release, but I don't see why.

ebola

 

[AMet(h)yl]

Methamphetamine + SNRI + DRI

okkkk, if both ebola? and wreckhead and zeta all agree,
tha concensus iz.......SSRI+NRI= safer meth xperience, but decreased effect.
which is xactly simiilar to ampz.
strange that its the same, no?

it also seemz that everyone agrees that baiscally:
DRI + METH = MDMA + SSRI...2 make a terrible mathematical metaphorical equation

meth is general is bad probly, forget with a SSRI.... but low doses like these, 1/4 pt every now n egain? not 2 bad, better than caffeine !?! maybe

maybe a half minmum/ultra low dose purely sertogernic ssri (lexapor) + normal/high dose nri (strattera/atmemoxtine?) so NET is covered, and SERT is minimally, but enuff 4 slight anti nuerotoxicity? and this would be the days(daze) ;p lol use, and a day after too, or maybe a nsri, like norep-serotRI, like higher NET than SERT, like maybe meridia or mianserin, like 1 pill insteada 2, i think duloxetine and venlaxafine r way 2 SERT active.

but lexapro n strattera r the only 2 easily found

 

[spork]

^Reply from OP

 

[ebola?]

okkkk, if both ebola? and wreckhead and zeta all agree,
tha concensus iz.......SSRI+NRI= safer meth xperience, but decreased effect.
which is xactly simiilar to ampz.
strange that its the same, no?

As far as I know, not exactly. There would be increased selectivity for DA due to a reduction in the NE effect. This might resemble something like a less serotonergic 4fa experience, rather than d-amp (d-amp effects greater activity at NE and less at 5ht (effectively none) than meth-amp).

DRI + METH = MDMA + SSRI...2 make a terrible mathematical metaphorical equation

This is more of an analogy than an equation, but sure, I guess, depending on the reuptake inhibitors' binding affinities.
...
Maybe trying to 'fix' meth with a bunch of other things is not an ideal strategy.

ebola