Mods, forgive me if there is a drug chemistry forum I'm not seeing, I'm a noob. I know not what I do.
There once was some chili. It appeared to be regular ole run of the mill chili. A little dirty, but nothing a quick recrystallization wouldn't fix. Definitely not the worst product in the world.
The chemist used some of it as-is, no post rxn workup, as he has done a zillion times before. However, the chili almost immediately turned jet-black upon heating and had a very strong taste. Just melting it was enough heat to scorch it terribly. The chemist thought it might be caused by a combination of impurities and the product not being totally dry, so a dual solvent recrystallization was performed using methanol and acetone and dried thoroughly. This cleaned up the product noticeably, however the problem persisted. The chemist decided to do some research on the issue and discovered that this could be a result of salting the meth freebase at too low pH.
Can anyone shed light on this issue? Would re-basing and re-salting at proper pH levels work to salvage the remaining product?
*EDIT*
Would this go in the Neuroscience & Pharmacology forum...?
There once was some chili. It appeared to be regular ole run of the mill chili. A little dirty, but nothing a quick recrystallization wouldn't fix. Definitely not the worst product in the world.
The chemist used some of it as-is, no post rxn workup, as he has done a zillion times before. However, the chili almost immediately turned jet-black upon heating and had a very strong taste. Just melting it was enough heat to scorch it terribly. The chemist thought it might be caused by a combination of impurities and the product not being totally dry, so a dual solvent recrystallization was performed using methanol and acetone and dried thoroughly. This cleaned up the product noticeably, however the problem persisted. The chemist decided to do some research on the issue and discovered that this could be a result of salting the meth freebase at too low pH.
Can anyone shed light on this issue? Would re-basing and re-salting at proper pH levels work to salvage the remaining product?
*EDIT*
Would this go in the Neuroscience & Pharmacology forum...?
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