Methadone is an opiate, used as a painkiller and as treatment for heroin addiction.
I would say that 15 mg would be enough for a person to feel it.
I usually like to do about 10 mg, just to get a warming, floaty body buzz, but I have a very low tolerance to opiates. I find any more than 15 mg and I will get a hangover the next day. The most methadone I have ever done is 25 mg and I was sick the next day - puked till I had nothing in me then dry heaves and bile for about 10 hours. Also, if you take a whole bunch, you get extremely itchy and it turns into an unpleasant experience. The most any one of my friends has tried is 32 mg but he has a huge tolerance to opiates.
It takes 1-2 hours to hit me full force, so don't go and take more thinking that you don't feel anything until you have let it hit you.
I really enjoy the effects of methadone as does my boyfriend. I agree that it is definitely worth trying.
[This message has been edited by phuKrd (edited 17 November 2001).]